Cited by 113Ubiquitin and proteasome pathwaysNicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology Research

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Nicotine Regulates Multiple Synaptic Proteins by Inhibiting Proteasomal Activity

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Rezvani, Khosrow, Teng, Yanfen, Shim, David, De Biasi, Mariella·2007·The Journal of Neuroscience

DOI 10.1523/jneurosci.3353-07.2007PMC PMC6673157

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Abstract

Ubiquitination regulates the degradation, membrane trafficking, and transcription of proteins. At mammalian synapses, the ubiquitin-proteasome system (UPS) influences synaptic transmission and plasticity. Nicotine also has the ability to affect synaptic function via mechanisms that remain partially unknown. We found that nicotine, at concentrations achieved by smokers, reduced proteasomal activity, produced accumulation of ubiquitinated synaptic proteins, and increased total protein levels. In particular, a 24 h exposure to nicotine decreased proteasome-dependent degradation of the alpha7 nicotinic acetylcholine receptor (nAChR) subunit, as indicated by the accumulation of ubiquitinated alpha7. The same nicotine treatment increased the levels of the AMPA glutamate receptor subunit GluR1, the NMDA receptor subunit NR2A, the metabotropic receptor mGluR1alpha, the plasticity factor Homer-1A, and the scaffolding postsynaptic density protein PSD-95, whereas the levels of another scaffolding protein, Shank, were reduced. These changes were associated with an inhibition of proteasomal chymotrypsin-like activity by nicotine. The nAChR antagonist mecamylamine was only partially able to block the effects of nicotine on the UPS, indicating that nAChR activation does not completely explain nicotine-induced inhibition of proteasomal catalytic activity. A competition binding assay suggested a direct interaction between nicotine and the 20S proteasome. These results suggest that the UPS might participate in nicotine-dependent synaptic plasticity.

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PDZ domain proteins of synapses
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Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity
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Conquet, F., Bashir, Z. I., Davies, C. H., Daniel, H., Ferraguti, F., Bordi, F., Franz-Bacon, K., Reggiani, A., Matarese, V., Condé, F., et al. (1994) · Nature · doi:10.1038/372237a0 · Cited by 743
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Show all 69 references

Research works printed but not linked: 1

Powers, 2005, Nicotinic receptor modulation of glutamate receptor expression in the mouse brain, Soc Neurosci Abstr, 31, 723

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Authors: Rezvani, K., Teng, Y., Shim, D., & De Biasi, M.
Affiliations: Baylor College of Medicine (US)
ORCID: Rezvani, Khosrow
Teng, Yanfen
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2007-09-26
Volume: 27
Issue: 39
Pages: 10508-10519
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.3353-07.2007
PMC: PMC6673157
OpenAlex: W2027624603
Cited by: 113
References: 69
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 5 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 9 · 2012: 15
FWCI: 4.50
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 182 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Philip Morris International
National Institute on Drug Abuse (DA017173, R01DA017173)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: nicotine, ubiquitin-proteasome system, proteasome inhibition, synaptic proteins, alpha7 nicotinic acetylcholine receptor, GluR1, NR2A, mGluR1alpha, Homer1a, PSD-95, shank, synaptic plasticity, chymotrypsin-like activity, mecamylamine, 20S proteasome, protein degradation
MeSH terms: Disks Large Homolog 4 Protein, Animals, Male, Membrane Proteins, Synaptic Transmission, Nicotine, Receptors, Nicotinic, Synapses, Protein Biosynthesis, Prefrontal Cortex, Receptors, Glutamate, Neurotransmitter Agents, Nicotinic Agonists, Models, Animal, Ubiquitin, Proteasome Endopeptidase Complex, Intracellular Signaling Peptides and Proteins, Mice, Guanylate Kinases, Proteasome Inhibitors

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Nicotine Regulates Multiple Synaptic Proteins by Inhibiting Proteasomal Activity

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