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Cited by 201Memory and Neural MechanismsNeurogenesis and neuroplasticity mechanismsNeural dynamics and brain function

The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.

Hippocampal Replay Captures the Unique Topological Structure of a Novel Environment

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Wu, Xiaojing, Foster, David J.·2014·The Journal of Neuroscience
DOI 10.1523/jneurosci.3414-13.2014PMC PMC4012305
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Abstract

Hippocampal place-cell replay has been proposed as a fundamental mechanism of learning and memory, which might support navigational learning and planning. An important hypothesis of relevance to these proposed functions is that the information encoded in replay should reflect the topological structure of experienced environments; that is, which places in the environment are connected with which others. Here we report several attributes of replay observed in rats exploring a novel forked environment that support the hypothesis. First, we observed that overlapping replays depicting divergent trajectories through the fork recruited the same population of cells with the same firing rates to represent the common portion of the trajectories. Second, replay tended to be directional and to flip the represented direction at the fork. Third, replay-associated sharp-wave–ripple events in the local field potential exhibited substructure that mapped onto the maze topology. Thus, the spatial complexity of our recording environment was accurately captured by replay: the underlying neuronal activities reflected the bifurcating shape, and both directionality and associated ripple structure reflected the segmentation of the maze. Finally, we observed that replays occurred rapidly after small numbers of experiences. Our results suggest that hippocampal replay captures learned information about environmental topology to support a role in navigation.

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  1. 10.1037//0097-7403.2.2.97 · DOI

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Metadata

Authors
Wu, X., & Foster, D. J.
Affiliations
Johns Hopkins University (US)
ORCID
Foster, David J.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2014-05-07
Volume
34
Issue
19
Pages
6459-6469
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.3414-13.2014
PMC
PMC4012305
OpenAlex
W2002978960
Cited by
201
References
41
Citations by year
2026: 9 · 2025: 17 · 2024: 17 · 2023: 16 · 2022: 10 · 2021: 18 · 2020: 18 · 2019: 26 · 2018: 23 · 2017: 18 · 2016: 21 · 2015: 7 · 2014: 1
FWCI
8.74
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Alfred P. Sloan Foundation
  • Whitehall Foundation
  • National Institutes of Health
  • National Institute of Mental Health (R01MH085823)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
hippocampal replay, place cells, maze navigation, sharp-wave ripples, local field potentials, novel environment, spatial memory
MeSH terms
Algorithms, Animals, Environment, Evoked Potentials, Hippocampus, Learning, Male, Neural Pathways, Neurons, Reward, Spatial Behavior, Linear Models, Maze Learning, Rats, Long-Evans, Rats, Electrophysiological Phenomena

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