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The Architecture of Reward Value Coding in the Human Orbitofrontal Cortex
Open accessAbstract
To ensure their survival, animals exhibit a number of reward-directed behaviors, such as foraging for food or searching for mates. This suggests that a core set of brain regions may be shared by many species to process different types of rewards. Conversely, many new brain areas have emerged over the course of evolution, suggesting potential specialization of specific brain regions in the processing of more recent rewards such as money. Here, using functional magnetic resonance imaging in humans, we identified the common and distinct brain systems processing the value of erotic stimuli and monetary gains. First, we provide evidence that a set of neural structures, including the ventral striatum, anterior insula, anterior cingulate cortex, and midbrain, encodes the subjective value of rewards regardless of their type, consistent with a general hedonic representation. More importantly, our results reveal reward-specific representations in the orbitofrontal cortex (OFC): whereas the anterior lateral OFC, a phylogenetically recent structure, processes monetary gains, the posterior lateral OFC, phylogenetically and ontogenetically older, processes more basic erotic stimuli. This dissociation between OFC representations of primary and secondary rewards parallels current views on lateral prefrontal cortex organization in cognitive control, suggesting an increasing trend in complexity along a postero-anterior axis according to more abstract representations. Together, our results support a modular view of reward value coding in the brain and propose that a unifying principle of postero-anterior organization can be applied to the OFC.
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“This medial–lateral gradient interacts with a second hedonic gradient along the posterior–anterior axis, which represents secondary reinforcers (such as money), more anteriorly in the OFC than primary reinforcers (such as odors, food, touch, sexual pleasure, or drugs) [15,28,29].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [28]
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Circular analysis in systems neuroscience: the dangers of double dipping
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A framework for studying the neurobiology of value-based decision making
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The neural correlates of subjective value during intertemporal choice
Kable, J. W., & Glimcher, P. W. (2007) · Nature Neuroscience · doi:10.1038/nn2007 · Cited by 1,916
Valid conjunction inference with the minimum statistic
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Behavioral Theories and the Neurophysiology of Reward
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Research works printed but not linked: 1
- Prevost C Pessiglione M Météreau E Clery-Melin ML Dreher JC (2010) Distinct valuation subsystems in the human brain for effort and delay. J Neurosci, in press.
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Bartra, O., McGuire, J. T., & Kable, J. W. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.02.063 · Cited by 1,927
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Frontal cortex and reward-guided learning and decision-making
Rushworth, M. F. S., Noonan, M. P., Boorman, E. D., Walton, M. E., & Behrens, T. E. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.014 · Cited by 1,111
Sescousse, G., Caldú, X., Segura, B., & Dreher, J.-C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.002 · Cited by 782
Self-citationInformatic parcellation of the network involved in the computation of subjective value
Clithero, J. A., & Rangel, A. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst106 · Cited by 706
Metadata
- Authors
- Sescousse, G., Redouté, J., & Dreher, J.-C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Lyon 1 Université (FR)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-09-29
- Volume
- 30
- Issue
- 39
- Pages
- 13095-13104
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6633499
- OpenAlex
- W1983640865
- Cited by
- 353
- References
- 62
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 16 · 2023: 8 · 2022: 20 · 2021: 31 · 2020: 39 · 2019: 14 · 2018: 22 · 2017: 20 · 2016: 34 · 2015: 27 · 2014: 28 · 2013: 27 · 2012: 26
- FWCI
- 14.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Fondation Fyssen
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- orbitofrontal cortex, erotic stimuli, monetary gain, ventral striatum, anterior insula, anterior cingulate cortex, midbrain, lateral prefrontal cortex
- MeSH terms
- Adult, Amygdala, Brain Mapping, Humans, Male, Motivation, Nerve Net, Neuropsychological Tests, Photic Stimulation, Predictive Value of Tests, Reward, Social Values, Prefrontal Cortex, Young Adult, Pleasure
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