The neurobiology of anhedonia and other reward-related deficits
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Anhedonia, or markedly diminished interest or pleasure, is a hallmark symptom of major depression, schizophrenia and other neuropsychiatric disorders. Over the past three decades, the clinical definition of anhedonia has remained relatively unchanged, although cognitive psychology and behavioral neuroscience have expanded our understanding of other reward-related processes. Here, we review the neural bases of the construct of anhedonia that reflects deficits in hedonic capacity and also closely linked to the constructs of reward valuation, decision-making, anticipation and motivation. The neural circuits subserving these reward-related processes include the ventral striatum, prefrontal cortical regions, and afferent and efferent projections. An understanding of anhedonia and other reward-related constructs will facilitate the diagnosis and treatment of disorders that include reward deficits as key symptoms.
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Studies of the neurobiology of reward processing have identified separate subtypes of anhedonia: consummatory, anticipatory, motivational, and decisional.
“studies of the neurobiology of reward processing have highlighted the variety of distinct pathways involved in its different aspects resulting in the recognition of separate subtypes of anhedonia, including consummatory, anticipatory, motivational and decisional [20,21].”
From Prefrontal cortex and depression (2022) · cites this paper as [21]
The Concluding Remarks distinguish consummatory and anticipatory anhedonia, but recommend limiting the term “anhedonia” to deficits in hedonic capacity. They treat motivation and decision-making as other reward-related processes, not as additional subtypes of anhedonia. (LLM, conf=0.87)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredIn some psychiatric disorders, such as addiction, schizophrenia, and depression, 'wanting' and 'liking' can become uncoupled as a result of circumscribed neurobiological dysfunctions.
“However, in some psychiatric disorders, such as addiction, schizophrenia, and depression, ‘wanting’ and ‘liking’ can become uncoupled as a result of circumscribed neurobiological dysfunctions [48].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [48]
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- Authors
- Der-Avakian, A., & Markou, A.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Markou, Athina
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 35
- Issue
- 1
- Pages
- 68-77
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC3253139
- OpenAlex
- W2012129255
- Cited by
- 1,130
- References
- 141
- Citations by year
- 2026: 67 · 2025: 101 · 2024: 76 · 2023: 97 · 2022: 93 · 2021: 168 · 2020: 57 · 2019: 88 · 2018: 69 · 2017: 52 · 2016: 70 · 2015: 60 · 2014: 56 · 2013: 57 · 2012: 18
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (F32MH080585, R01MH087989, R01MH62527)
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- anhedonia, reward processing, reward valuation, decision-making, reward anticipation, motivation, major depressive disorder, schizophrenia, ventral striatum, prefrontal cortex, neural circuits, hedonic capacity
- MeSH terms
- Animals, Mental Disorders, Humans, Neural Pathways, Neurobiology, Reward, Prefrontal Cortex, Anhedonia
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