Plasticity compartments in basal dendrites of neocortical pyramidal neurons
Open accessAbstract
Synaptic plasticity rules widely determine how cortical networks develop and store information. Using confocal imaging and dual site focal synaptic stimulation, we show that basal dendrites, which receive the majority of synapses innervating neocortical pyramidal neurons, contain two compartments with respect to plasticity rules. Synapses innervating the proximal basal tree are easily modified when paired with the global activity of the neuron. In contrast, synapses innervating the distal basal tree fail to change in response to global suprathreshold activity or local dendritic spikes. These synapses can undergo long-term potentiation under unusual conditions when local NMDA spikes, which evoke large calcium transients, are paired with a “gating molecule,” BDNF. Moreover, these synapses use a new temporal plasticity rule, which is an order of magnitude longer than spike timing dependent plasticity and prefers reversed presynaptic/postsynaptic activation order. The newly described plasticity compartmentalization of basal dendrites expands the networks plasticity rules and may support different learning and developmental functions.
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The proximal and distal segments of basal dendrites have different characteristics with respect to integration and synaptic plasticity.
“Moreover, the proximal and distal segments of basal dendrites have different characteristics with respect to integration and synaptic plasticity (Markram et al., 1997; Hausser and Mel, 2003; Gordon et al., 2006; Gelfo et al., 2009; Branco and Häusser, 2011).”
From The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer’s disease (2013) · cites this paper as Gordon et al., 2006
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- Authors
- Gordon, U., Polsky, A., & Schiller, J.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Corresponding author
- Schiller, Jackie
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-12-06
- Volume
- 26
- Issue
- 49
- Pages
- 12717-12726
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6674852
- OpenAlex
- W1974719053
- Cited by
- 157
- References
- 5
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 11 · 2018: 12 · 2017: 14 · 2016: 11 · 2015: 8 · 2014: 15 · 2013: 3 · 2012: 8
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Rappaport Foundation
- Israel Science Foundation
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- basal dendrites, neocortical pyramidal neurons, synaptic plasticity, long-term potentiation, brain-derived neurotrophic factor, temporal plasticity, spike-timing-dependent plasticity, dendritic calcium transients, paired-pulse plasticity, dendritic spikes, cortical development
- MeSH terms
- Action Potentials, Animals, Dendrites, Female, Male, Neuronal Plasticity, Rats, Wistar, Pyramidal Cells, Neocortex, Calcium Signaling, Rats
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