The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo
Open accessAbstract
The three human alleles of apolipoprotein E (APOE) differentially influence outcome after CNS injury and affect one's risk of developing Alzheimer's disease (AD). It remains unclear how ApoE isoforms contribute to various AD-related pathological changes (e.g., amyloid plaques and synaptic and neuron loss). Here, we systematically examined whether apoE isoforms (E2, E3, E4) exhibit differential effects on dendritic spine density and morphology in APOE targeted replacement (TR) mice, which lack AD pathological changes. Using Golgi staining, we found age-dependent effects of APOE4 on spine density in the cortex. The APOE4 TR mice had significantly reduced spine density at three independent time points (4 weeks, 3 months, and 1 year, 27.7% ± 7.4%, 24.4% ± 8.6%, and 55.6% ± 10.5%, respectively) compared with APOE3 TR mice and APOE2 TR mice. Additionally, in APOE4 TR mice, shorter spines were evident compared with other APOE TR mice at 1 year. APOE2 TR mice exhibited longer spines as well as significantly increased apical dendritic arborization in the cortex compared with APOE4 and APOE3 TR mice at 4 weeks. However, there were no differences in spine density across APOE genotypes in hippocampus. These findings demonstrate that apoE isoforms differentially affect dendritic complexity and spine formation, suggesting a role for APOE genotypes not only in acute and chronic brain injuries including AD, but also in normal brain functions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“They compared dendritic spine number and length between neurons from mice lacking apoE altogether and mice in which a human APOE isoform replaced the mouse APOE gene, and demonstrated that the presence of any human apoE isoform led to increased spine number at 3 months of age in comparison to mice that lack apoE [Dumanis et al. (2009), their Fig.3A-C].”
From Differential Effects of ApoE Isoforms on Dendritic Spines In Vivo: Linking an Alzheimer's Disease Risk Factor with Synaptic Alterations (2010) · cites this paper as Dumanis et al. (2009)
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“One of the principal findings was that, at all ages examined, mice expressing APOE4 had significantly fewer dendritic spines in layer II/III cortical pyramidal neurons than mice expressing APOE2 or APOE3 [Dumanis et al. (2009), their Fig. 1, Fig. 3].”
From Differential Effects of ApoE Isoforms on Dendritic Spines In Vivo: Linking an Alzheimer's Disease Risk Factor with Synaptic Alterations (2010) · cites this paper as Dumanis et al. (2009)
The cited source says what the claim attributes to it.
In the citing paper
“The study by Dumanis et al. (2009) is the first to systematically compare dendritic spines in vivo in mice in which the human APOE2, APOE3, or APOE4 gene has been substituted into the mouse APOE locus.”
From Differential Effects of ApoE Isoforms on Dendritic Spines In Vivo: Linking an Alzheimer's Disease Risk Factor with Synaptic Alterations (2010) · cites this paper as Dumanis et al. (2009)
The cited source says what the claim attributes to it.
In the citing paper
“Dumanis et al. (2009) also found that spine length differed between mice expressing different APOE isoforms.”
From Differential Effects of ApoE Isoforms on Dendritic Spines In Vivo: Linking an Alzheimer's Disease Risk Factor with Synaptic Alterations (2010) · cites this paper as Dumanis et al. (2009)
The cited source says what the claim attributes to it.
In the citing paper
“In the 1-year-old cohort, the mice expressing the APOE4 gene had shorter spines than APOE2 and APOE3 mice [Dumanis et al. (2009), their Fig.3H].”
From Differential Effects of ApoE Isoforms on Dendritic Spines In Vivo: Linking an Alzheimer's Disease Risk Factor with Synaptic Alterations (2010) · cites this paper as Dumanis et al. (2009)
The cited source says what the claim attributes to it.
In the citing paper
“At 1 month of age, APOE2 mice had longer cortical spines than APOE3 and APOE4 mice [Dumanis et al. (2009), their Fig. 1 F-H].”
From Differential Effects of ApoE Isoforms on Dendritic Spines In Vivo: Linking an Alzheimer's Disease Risk Factor with Synaptic Alterations (2010) · cites this paper as Dumanis et al. (2009)
The cited source says what the claim attributes to it.
In the citing paper
“No differences in cortical spine density between APOE2 and APOE3 mice were observed [Dumanis et al. (2009), their Fig. 1, Fig. 3].”
From Differential Effects of ApoE Isoforms on Dendritic Spines In Vivo: Linking an Alzheimer's Disease Risk Factor with Synaptic Alterations (2010) · cites this paper as Dumanis et al. (2009)
The cited source says what the claim attributes to it.
In the citing paper
“This, however, does not rule out the possibility the structural synaptic changes might be present that have been observed by others (Dumanis et al., 2009).”
From Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-β Amyloidosis (2011) · cites this paper as Dumanis et al., 2009
The cited source says what the claim attributes to it.
In the citing paper
“Other previous studies also reported an association between the apoE4 and spine deficits in vivo (Basak and Kim, 2010; Dumanis et al., 2009; Ji et al., 2003; Wang et al., 2005).”
From Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms (2014) · cites this paper as Dumanis et al., 2009
The cited source says what the claim attributes to it.
In the citing paper
“apolipoprotein (apo) E4–a major genetic risk factor for Alzheimer's disease–decreases spine density both in vivo [18], [19] and in vitro [20], [21]”
From Arf4 Determines Dentate Gyrus-Mediated Pattern Separation by Regulating Dendritic Spine Development (2012) · cites this paper as [18]
In the citing paper
“In another study, human APOE ε4 was found to reduce dendritic length and branching in the mouse cortex and hippocampus67.”
From Dendritic spine pathology in neuropsychiatric disorders (2011) · cites this paper as [67]
In the citing paper
“ApoE4 impairs synaptogenesis and decreases dendritic spine density in vivo and in vitro in primary neuronal cultures [72, 73].”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [73]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376
CNS synaptogenesis promoted by glia-derived cholesterol
Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711
Distinct patterns of brain activity in young carriers of the APOE -ε4 allele
Filippini, N., MacIntosh, B. J., Hough, M. G., Goodwin, G. M., Frisoni, G. B., Smith, S. M., Matthews, P. M., Beckmann, C. F., & Mackay, C. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811879106 · Cited by 1,613
Apolipoprotein E polymorphism and Alzheimer's disease
Poirier, J., Bertrand, P., Poirier, J., Kogan, S., Gauthier, S., Poirier, J., Gauthier, S., Davignon, J., Bouthillier, D., & Davignon, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)91705-q · Cited by 1,108
Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
William Rebeck, G., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90070-8 · Cited by 1,107
Self-citationDifferential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro
Nathan, B. P., Bellosta, S., Sanan, D. A., Weisgraber, K. H., Mahley, R. W., & Pitas, R. E. (1994) · Science · doi:10.1126/science.8171342 · Cited by 795
Association of apolipoprotein E polymorphism with outcome after head injury
Teasdale, G. M., Nicoll, J. A. R., Murray, G. D., & Fiddes, M. (1997) · The Lancet · doi:10.1016/s0140-6736(97)04318-3 · Cited by 683
Sullivan, P. M., Mezdour, H., Aratani, Y., Knouff, C., Najib, J., Reddick, R. L., Quarfordt, S. H., & Maeda, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.17972 · Cited by 575
Regulation of Dendritic Spine Morphology by SPAR, a PSD-95-Associated RapGAP
Pak, D. T. S., Yang, S., Rudolph-Correia, S., Kim, E., & Sheng, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00355-5 · Cited by 395
Cited by
Sorted by citations
Items 101–200 of 220
More than just risk for Alzheimer’s disease: APOE ε4's impact on the aging brain
Palmer, J. M., Huentelman, M. J., & Ryan, L. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.06.003 · Cited by 39
Fitz, N. F., Tapias, V., Cronican, A. A., Castranio, E. L., Saleem, M., Carter, A. Y., Lefterova, M. I., Lefterov, I. M., & Koldamova, R. P. (2015) · Brain · doi:10.1093/brain/awv293 · Cited by 38
Aβ-related memory decline in APOE ε4 noncarriers
Lim, Y. Y., Laws, S. M., Villemagne, V. L., Pietrzak, R. H., Porter, T., Ames, D. J., Fowler, C. J., Rainey‐Smith, S. R., Snyder, P. J., Martins, R. N., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002604 · Cited by 39
Chhibber, A., & Zhao, L. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0305-3 · Cited by 36
Rolyan, H., Feike, A. C., Upadhaya, A. R., Waha, A., Dooren, T. V., Haass, C., Birkenmeier, G., Pietrzik, C. U., LEUVEN, F. V., & Thal, D. R. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-010-0572-7 · Cited by 39
Nwabuisi‐Heath, E., Rebeck, G. W., LaDu, M. J., & Yu, C. (2013) · ASN NEURO · doi:10.1042/an20130043 · Cited by 38
Self-citationTRPM7 Is Required for Normal Synapse Density, Learning, and Memory at Different Developmental Stages
Liu, Y., Chen, C., Liu, Y., Li, W., Wang, Z., Sun, Q., Zhou, H., Chen, X., Yu, Y., Wang, Y., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.069 · Cited by 35
Flinn, J. M., Bozzelli, P. L., Adlard, P. A., & Railey, A. M. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00174 · Cited by 37
Lattanzio, F., Carboni, L., Carretta, D., Rimondini, R., Candeletti, S., & Romualdi, P. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.017 · Cited by 34
Ramakrishna, S., Jhaveri, V., Konings, S. C., Nawalpuri, B., Chakraborty, S., Holst, B., Schmid, B., Gouras, G. K., Freude, K., & Muddashetty, R. S. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0435-21.2021 · Cited by 34
Preman, P., Moechars, D., Fertan, E., Wolfs, L., Serneels, L., Shah, D., Lamote, J., Poovathingal, S., Snellinx, A., Mancuso, R., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00162-7 · Cited by 32
Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease
Ma, Q., Teng, E., Zuo, X., Jones, M. R., Teter, B., Zhao, E. Y., Zhu, C., Bilousova, T. V., Gylys, K. H., Apostolova, L. G., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.02.014 · Cited by 34
Self-citationIacono, D., & Feltis, G. C. (2019) · Aging · doi:10.18632/aging.101757 · Cited by 36
Green, A. E., Gray, J. R., DeYoung, C. G., Mhyre, T. R., Padilla, R. M., DiBattista, A. M., & Rebeck, G. W. (2014) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2013.12.020 · Cited by 32
Self-citationYu, T., Tensaouti, Y., Stephanz, E. P., Chintamen, S., Rafikian, E. E., Yang, M., & Kernie, S. G. (2021) · Communications Biology · doi:10.1038/s42003-021-02841-4 · Cited by 33
Zhang, Y., Gao, H., Zheng, W., & Xu, H. J. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105824 · Cited by 31
Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice
Klein, R. C., Acheson, S. K., Mace, B. E., Sullivan, P. M., & Moore, S. D. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.019 · Cited by 29
Identification and modification of amyloid-independent phenotypes of APOE4 mice
DiBattista, A. M., Dumanis, S. B., Newman, J., & Rebeck, G. W. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.04.014 · Cited by 28
Self-citationAre apolipoprotein E fragments a promising new therapeutic target for Alzheimer’s disease?
Vecchio, F. L., Bisceglia, P., Imbimbo, B. P., Lozupone, M., Latino, R. R., Resta, E., Leone, M., Solfrizzi, V., Greco, A., Daniele, A., et al. (2022) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223221081605 · Cited by 28
Qiao, F., Gao, X., Li, Y., Cai, H.-Y., & Qi, J. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140375 · Cited by 29
Taxier, L. R., Philippi, S. M., York, J. M., LaDu, M. J., & Frick, K. M. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.12.006 · Cited by 27
Self-citationLien, E., Andersen, G. L., Bao, Y., Gordish‐Dressman, H., Skranes, J. S., Vik, T., & Blackman, J. A. (2013) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.12086 · Cited by 26
Aging and Apolipoprotein E in HIV Infection
Geffin, R., & McCarthy, M. (2018) · Journal of NeuroVirology · doi:10.1007/s13365-018-0660-2 · Cited by 29
White Matter Alterations in Cognitively Normal apoE ɛ2 Carriers: Insight into Alzheimer Resistance?
Chiang, G. C., Zhan, W., Schuff, N., & Weiner, M. W. (2012) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2984 · Cited by 25
Pharmacological Strategies to Improve Dendritic Spines in Alzheimer’s Disease
Ettcheto, M., Busquets, O., Cano, A. C., Sánchez‐López, E., Manzine, P. R., Espinosa-Jiménez, T., Verdaguer, E., Sureda, F. X., Olloquequi, J., Castro-Torres, R. D., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-201106 · Cited by 25
Rademacher, T.-D., Meuth, S. G., Wiendl, H., Johnen, A., & Landmeyer, N. C. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105035 · Cited by 27
STX, a Novel Membrane Estrogen Receptor Ligand, Protects Against Amyloid-β Toxicity
Gray, N. E., Zweig, J. A., Kawamoto, C., Quinn, J. F., & Copenhaver, P. F. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150756 · Cited by 25
Sepulveda, J., Luo, N., Nelson, M., Ng, C. A. S., & Rebeck, G. W. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15665 · Cited by 24
Self-citationHigh-density lipoprotein-related cholesterol metabolism in Alzheimer's disease
Pedrini, S., Chatterjee, P., Hone, E., & Martins, R. N. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15170 · Cited by 22
Zhang, J., Lin, L., Dai, X., Xiao, N., Ye, Q., & Chen, X. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.09.029 · Cited by 26
Woody, S. K., Zhou, H., Ibrahimi, S., Dong, Y., & Zhao, L. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-160307 · Cited by 23
Linking Diabetes to Alzheimer’s Disease: Potential Roles of Glucose Metabolism and Alpha-Glucosidase
Wee, A. S., Nhu, T. D., Khaw, K. Y., Tang, K. S., & Yeong, K. Y. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21999221111102343 · Cited by 24
The Age of Cortical Neural Networks Affects Their Interactions with Magnetic Nanoparticles
Tay, A. K. P., Kunze, A., Jun, D., Hoek, E. M. V., & Carlo, D. D. (2016) · Small · doi:10.1002/smll.201600673 · Cited by 23
Watanabe, H., Murakami, R., Tsumagari, K., Morimoto, S., Hashimoto, T., Imaizumi, K., Sonn, I., Yamada, K., Saito, Y., Murayama, S., et al. (2023) · Stem Cell Reports · doi:10.1016/j.stemcr.2023.08.002 · Cited by 24
Neuronal Protein Farnesylation Regulates Hippocampal Synaptic Plasticity and Cognitive Function
Qu, W., Suazo, K. F., Liu, W., Cheng, S., Jeong, A., Hottman, D. A., Yuan, L., Distefano, M. D., & Li, L. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02169-w · Cited by 22
Taxier, L. R., Philippi, S. M., Fleischer, A. W., York, J. M., LaDu, M. J., & Frick, K. M. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.06.005 · Cited by 25
Self-citationApolipoprotein E in Alzheimer’s Disease: Focus on Synaptic Function and Therapeutic Strategy
Qu, L., Xu, S., Lan, Z., Fang, S., Xu, Y., & Zhu, X. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04449-1 · Cited by 22
Wearn, A. R., Tremblay, S. A., Tardif, C. L., Leppert, I. R., Gauthier, C. J., Baracchini, G., Hughes, C. S., Hewan, P., Tremblay‐Mercier, J., Rosa‐Neto, P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48490-z · Cited by 27
Novel approaches to increase synaptic resilience as potential treatments for Alzheimer’s disease
Pham, A. Q., & Dore, K. (2023) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2022.03.032 · Cited by 21
Cognitively Normal APOE ε4 Carriers Have Specific Elevation of CSF SNAP-25
Butt, O. H., Long, J. M., Henson, R. L., Herries, E. M., Sutphen, C. L., Fagan, A. M., Cruchaga, C., Ladenson, J. H., Holtzman, D. M., Morris, J. C., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.02.008 · Cited by 21
Venzi, M., Tóth, M., Häggkvist, J., Bogstedt, A., Rachalski, A., Mattsson, A., Frumento, P., & Farde, L. (2017) · Journal of Alzheimer's Disease Reports · doi:10.3233/adr-170006 · Cited by 18
Shen, S., Zhou, W., Chen, X., & Zhang, J. (2019) · European Journal of Neurology · doi:10.1111/ene.13987 · Cited by 18
Neustadtl, A. L., Winston, C. N., Parsadanian, M., Main, B. S., Villapol, S., & Burns, M. P. (2017) · Neuroreport · doi:10.1097/wnr.0000000000000811 · Cited by 22
Geerts, H., & Spiros, Ä. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12082 · Cited by 19
Han, F., Xu, H., Shen, J.-X., Pan, C., Yu, Z.-H., Chen, J.-J., Zhu, X.-L., Cai, Y.-F., & Lu, Y.-P. (2020) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2020-021 · Cited by 18
Piccarducci, R., Giacomelli, C., Bertilacchi, M. S., Benito-Martínez, A., Giorgi, N. D., Daniele, S., Signore, G., Rocchiccioli, S., Vilar, M., Marchetti, L., et al. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166793 · Cited by 19
Hottman, D. A., Cheng, S., Gram, A., LeBlanc, K. J., Yuan, L., & Li, L. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.01.026 · Cited by 17
Neuroprotective Effects of Tripeptides—Epigenetic Regulators in Mouse Model of Alzheimer’s Disease
Khavinson, V. K., Ilina, A., Kraskovskaya, N., Linkova, N. S., Колчина, Н. В., Mironova, E. S., Erofeev, A., & Petukhov, M. (2021) · Pharmaceuticals · doi:10.3390/ph14060515 · Cited by 17
ApoE4 attenuates cortical neuronal activity in young behaving apoE4 rats
Har-Paz, I., Arieli, E., & Moran, A. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105373 · Cited by 14
Wang, X., Zhang, X., Liu, J., Zhang, J., Liu, C., Cui, Y., Song, Q., Hou, Y., Wang, Y., Zhang, Q., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01440-9 · Cited by 15
The association of apolipoprotein E gene polymorphisms with cerebral palsy in Chinese infants
Xu, Y., Wang, H., Sun, Y., Shang, Q., Chen, M., Li, T., Zhu, D., He, L., Zhu, C., & Xing, Q. (2014) · Molecular Genetics and Genomics · doi:10.1007/s00438-014-0818-4 · Cited by 16
Goikolea-Vives, A., & Stolp, H. B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158220 · Cited by 15
Sex-Specific Protective Effects ofAPOEε2 on Cognitive Performance
Lamonja-Vicente, N., Dacosta‐Aguayo, R., López-Olóriz, J., Prades-Senovilla, L., Roig-Coll, F., Castells-Sánchez, A., Soriano-Raya, J. J., Clemente, I. C., Miralbell, J., Barrios, M., et al. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa247 · Cited by 15
ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease
Lennol, M. P., Bordier, C., Kamelher, L., Ulrich, J. D., Holtzman, D. M., & Gratuze, M. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20250965 · Cited by 14
SV2A PET shows hippocampal synaptic loss in cognitively unimpaired APOE ε4/ε4 homozygotes
Snellman, A., Tuisku, J., Koivumäki, M., Wahlroos, S., Aarnio, R., Rajander, J., Karrasch, M., Ekblad, L. L., & Rinne, J. O. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14327 · Cited by 16
Klonarakis, M., Vos, M. D., Woo, E. K., Ralph, L. T., Thacker, J. S., & Gil‐Mohapel, J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104541 · Cited by 14
Does metabolic failure at the synapse cause Alzheimer’s disease?
Engel, P. A. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.10.013 · Cited by 13
Genetic Architecture of Declarative Memory
Bearden, C. E., Karlsgodt, K. H., Bachman, P., van Erp, T. G. M., Winkler, A. M., & Glahn, D. C. (2011) · The Neuroscientist · doi:10.1177/1073858411415113 · Cited by 13
Accelerated midlife endocrine and bioenergetic brain aging in APOE4 females
Wang, T., Mao, Z., Shang, Y., Merlini, S., Vitali, F., Wiegand, J. L., & Brinton, R. D. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1632877 · Cited by 12
Greco, G. A., Rock, M. B., Amontree, M., Lanfranco, M. F., Korthas, H. T., Hong, S. H., Turner, R. S., Rebeck, G. W., & Conant, K. E. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106057 · Cited by 11
Self-citationAPOE ɛ4 exacerbates age-dependent deficits in cortical microstructure
Mak, E., Dounavi, M., Operto, G., Ziukelis, E. T., Jones, P. S., Low, A., Swann, P., Newton, C., Terrera, G. M., Malhotra, P., et al. (2023) · Brain Communications · doi:10.1093/braincomms/fcad351 · Cited by 13
Yang, X., Yao, K., Zhang, M., Zhang, W., & Zu, H. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111321 · Cited by 12
Child apolipoprotein E gene variants and risk of cerebral palsy: Estimation from case–parent triads
Stoknes, M., Lien, E., Andersen, G. L., Bao, Y., Blackman, J. A., Lie, R. T., & Vik, T. (2015) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2014.12.017 · Cited by 11
Pathologies Underlying Longitudinal Cognitive Decline in the Oldest Old
Nguyen, M. T., Mattek, N., Woltjer, R. L., Howieson, D. B., Silbert, L. C., Hofer, S. M., Kaye, J. A., Dodge, H. H., & Erten‐Lyons, D. (2018) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000265 · Cited by 10
Self-citationJurasova, V., Andel, R., Katonová, A., Veverová, K., Zuntychová, T., Horáková, H., Vyhnálek, M., Kolářová, T., Maťoška, V., Blennow, K., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01566-w · Cited by 10
Diaz, J. R., Martá-Ariza, M., Khodadadi‐Jamayran, A., Heguy, A., Tsirigos, A., Pankiewicz, J. E., Sullivan, P. M., & Sadowski, M. J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.845291 · Cited by 11
The effect of β‐amyloid positivity on cerebral metabolism in cognitively normal seniors
Bozoki, A., Zdanukiewicz, M., Zhu, D. C., & Initiative, A. D. N. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.003 · Cited by 9
Ganesan, K., Rentsch, P., Langdon, A., Milham, L. T., & Vissel, B. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1357405 · Cited by 11
Gene sequences regulating the production of apoE and cerebral palsy of variable severity
Lien, E., Andersen, G. L., Bao, Y., Gordish‐Dressman, H., Skranes, J. S., Blackman, J. A., & Vik, T. (2014) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2014.04.003 · Cited by 9
Bott, J.-B., Cosquer, B., Héraud, C., Zerbinatti, C., Kelche, C. R., Cassel, J., & Mathis, C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.04.018 · Cited by 10
Klein, R. C., Saini, S., Risher, M., Acheson, S. K., Fleming, R. L., Sexton, H. G., Swartzwelder, H. S., & Moore, S. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094071 · Cited by 8
Association of Alzheimer's Disease With APOE and IL-1α Gene Polymorphisms
Yıldız, S. H., Erdoğan, M. Ö., Artan, S., Solak, M., Yaman, M., Ozbabalik, B. D., & Söylemez, E. S. A. (2012) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317512461557 · Cited by 8
Animal Models of Alzheimer’s Disease
Amram, S., & Frenkel, D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803690-7.00003-x · Cited by 8
Asiamah, E. A., Feng, B., Guo, R., Yaxing, X., Du, X., Liu, X., Zhang, J., Cui, H., & Ma, J. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230658 · Cited by 8
New APOE-related therapeutic options for Alzheimer’s disease
Li, Z. (2019) · AIP conference proceedings · doi:10.1063/1.5085515 · Cited by 8
Apolipoprotein E loss of function: Influence on murine brain markers of physiology and pathology
Buchanan, H. M., Hull, C. E., Barraza, M. C., Delibegović, M., & Platt, B. (2022) · Aging Brain · doi:10.1016/j.nbas.2022.100055 · Cited by 7
Genetic Variation in the Ontario Neurodegenerative Disease Research Initiative
Dilliott, A. A., Evans, E. C., Farhan, S. M. K., Ghani, M., Sato, C., Zhang, M., McIntyre, A. D., Cao, H., Racacho, L., Robinson, J. F., et al. (2019) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2019.228 · Cited by 8
A modeling informed quantitative approach to salvage clinical trials interrupted due to COVID‐19
Geerts, H., & van der Graaf, P. H. (2020) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12053 · Cited by 6
Basak, J. M., & Kim, J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0505-10.2010 · Cited by 6
“In the 1-year-old cohort, the mice expressing the APOE4 gene had shorter spines than APOE2 and APOE3 mice [Dumanis et al. (2009), their Fig.”
BackgroundMethodResultInfluentialTargeting apolipoprotein E for treating Alzheimer’s disease
Bales, K. R., & Paul, S. M. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134366 · Cited by 7
Apolipoprotein E and Amyloid-β-Independent Mechanisms in Alzheimer’s Disease
Kanekiyo, T., & Bu, G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802851-3.00006-1 · Cited by 6
Geerts, H., & Spiros, Ä. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200688 · Cited by 7
Bowirrat, A., Pinhasov, A., Bowirrat, A., & Badgaiyan, R. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178253 · Cited by 6
Patil, S. P., & Kuehn, B. R. (2024) · Pharmaceuticals · doi:10.3390/ph17040491 · Cited by 6
Effect of APOE Genotype on Synaptic Proteins in Earlier Adult Life
Sinclair, L. I., & Love, S. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170316 · Cited by 4
Defining the Neuropathological Aggresome across in Silico, in Vitro, and ex Vivo Experiments
Gomes, G.-N. W., & Levine, Z. A. (2021) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.0c09193 · Cited by 4
Imaging and rare APOE alleles: Alzheimer disease as a developmental disorder
Knickmeyer, R. C., & Ross, M. E. (2016) · Neurology · doi:10.1212/wnl.0000000000002956 · Cited by 3
Naffaa, M. M. (2025) · Lifespan development and mental health. · doi:10.70322/ldmh.2025.10005 · Cited by 3
Labuza, A., Pidikiti, H., Alldred, M. J., Ibrahim, K. W., Peng, K. Y., Pasato, J., Heguy, A., Mathews, P. M., & Ginsberg, S. D. (2025) · Brain Sciences · doi:10.3390/brainsci15101117 · Cited by 4
Jiraanont, P., Wang, J. Y., Durbin-Johnson, B., Hwang, Y. H., Hessl, D. R., Rivera, S. M., Hagerman, R. J., & Tassone, F. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107292 · Cited by 3
Grone, B. P., Zalocusky, K. A., Hao, Y., Yoon, S. Y., Arriola, P., & Huang, Y. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.16.496371 · Cited by 3
Iacono, D. (2025) · Neuroethics · doi:10.1007/s12152-025-09624-2 · Cited by 2
Delbono, O., Wang, Z., & Messi, M. L. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102999 · Cited by 3
Dendritic spine pathology in neuropsychiatric
Cahill, M. E., Jones, K. A., VanLeeuwen, J., & Woolfrey, K. M. (2011) · Cited by 2
Alzheimer Disease and Dementia
AYDIN, A. C. (2020) · Journal of Literature Pharmacy Sciences · doi:10.5336/pharmsci.2019-71813 · Cited by 3
Khan, J., & Tatlı, I. İ. (2023) · Springer eBooks · doi:10.1007/978-981-99-3848-3_8 · Cited by 2
The Amyloid _-Protein and Alzheimer's Disease
Teplow, D. B., Yang, M., Roychaudhuri, R., Pang, E. S., Huynh, T. V., Chen, M., & Beroukhim, S. (2012) · Frontiers in neuroscience · doi:10.1201/b11986-2 · Cited by 2
Matos, M., Oliveira, A. S., Matias, I., Boulch, A. L., Ciofi, P., Dupuy, L., Huc, E., Oliet, S. H. R., & Panatier, A. (2026) · Alzheimer s Research & Therapy · doi:10.1186/s13195-026-01992-y · Cited by 1
Luo, N., Pandit, H., Kalra, S., Tran, E., Mandelblatt, J. S., Vicini, S., & Rebeck, G. W. (2026) · PLoS ONE · doi:10.1371/journal.pone.0343276 · Cited by 1
Self-citationNaeem, A., McCormack, M., Lein, R., Pérez, M. S., Knoer, G., Garcia, S., Kausch, M., Lee, Y., Carroll, J., Cole, S., et al. (2026) · American Journal Of Pathology · doi:10.1016/j.ajpath.2026.05.004 · Cited by 1
Self-citation
Metadata
- Authors
- Dumanis, S. B., Tesoriero, J. A., Babus, L. W., Nguyen, M. T., Trotter, J. H., Ladu, M. J., Weeber, E. J., Turner, R. S., Xu, B., Rebeck, G. W., & Hoe, H.-S.
- Affiliations
- Georgetown University Medical Center (US)
- Georgetown University (US)
- University of South Florida (US)
- University of Illinois Chicago (US)
- Corresponding author
- Hoe, Hyang-Sook
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-12-02
- Volume
- 29
- Issue
- 48
- Pages
- 15317-15322
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2846754
- OpenAlex
- W2167047846
- Cited by
- 220
- References
- 31
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 10 · 2023: 8 · 2022: 15 · 2021: 16 · 2020: 18 · 2019: 14 · 2018: 14 · 2017: 10 · 2016: 17 · 2015: 7 · 2014: 19 · 2013: 18 · 2012: 15
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Georgetown University
- National Institutes of Health
- National Institute on Aging (R01AG026478, P01AG030128, R29AG014473, R03AG032330, R01AG014473, AG032330, AG026478, AG014473)
- National Institute of Neurological Disorders and Stroke (R01NS050596)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- apolipoprotein E, APOE ε4, APOE isoforms, dendritic spine density, dendritic complexity, cortical neurons, hippocampus, Alzheimer's disease risk, synaptic plasticity
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Cells, Cultured, Cerebral Cortex, Dendrites, Embryo, Mammalian, Hippocampus, Humans, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Silver Staining, Rats, Sprague-Dawley, Protein Isoforms, Dendritic Spines, Mice, Rats, Apolipoprotein E3, Apolipoprotein E4, Apolipoprotein E2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
