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Cited by 19Neuroscience and Neural EngineeringTactile and Sensory InteractionsEEG and Brain-Computer Interfaces

Amputation with median nerve redirection (targeted reinnervation) reactivates forepaw barrel subfield in rats

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Marasco, Paul D., Kuiken, Todd A.·2010·The Journal of Neuroscience
DOI 10.1523/jneurosci.4044-10.2010PMC PMC3073552
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Abstract

Prosthetic limbs are difficult to control and do not provide sensory feedback. Targeted reinnervation was developed as a neural–machine interface for amputees to address these issues. In targeted reinnervation, amputated nerves are redirected to proximal muscles and skin, creating nerve interfaces for prosthesis control and sensory feedback. Touching the reinnervated skin causes sensation to be projected to the missing limb. Here we use electrophysiological brain recording in the Sprague Dawley rat to investigate the changes to somatosensory cortex (S1) following amputation and nerve redirection with the intent to provide insight into the sensory phenomena observed in human targeted reinnervation amputees. Recordings revealed that redirected nerves established an expanded representation in S1, which may help to explain the projected sensations that encompass large areas of the hand in targeted reinnervation amputees. These results also provide evidence that the reinnervated target skin could serve as a line of communication from a prosthesis to cortical hand processing regions. S1 border regions were simultaneously responsive to reinnervated input and also vibrissae, lower lip, and hindfoot, suggesting competition for deactivated cortical territory. Electrically evoked potential latencies from reinnervated skin to cortex suggest direct connection of the redirected afferents to the forepaw processing region of S1. Latencies also provide evidence that the widespread reactivation of S1 cortex may arise from central anatomical interconnectivity. Targeted reinnervation offers the opportunity to examine the cortical plasticity effects when behaviorally important sensory afferents are redirected from their original location to a new skin surface on a different part of the body.

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  • When target skin of TR patients was touched, they felt as if their missing limb was being touched.

    “When the target skin of these patients was touched, they felt as if their missing limb was being touched (Kuiken et al., 2007a; Marasco and Kuiken, 2010).”

    From Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review. (2017) · cites this paper as Marasco and Kuiken, 2010

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Cited by

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Authors
Marasco, P. D., & Kuiken, T. A.
Affiliations
  • Shirley Ryan AbilityLab (US)
  • Northwestern University (US)
ORCID
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2010-11-24
Volume
30
Issue
47
Pages
16008-16014
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.4044-10.2010
PMC
PMC3073552
OpenAlex
W1973035907
Cited by
19
References
4
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 2
FWCI
0.52
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Chicago Community Trust
  • National Institutes of Health (5r01hd043137-05)
  • Defense Advanced Research Projects Agency
  • Advanced Research Projects Agency
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01-HD-4-4798, R01 HD-043137, R01HD044798, R01-HD-4-3137, N01-HD-53402, N01 HD053402)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
Keywords
amputation, somatosensory cortex, cortical plasticity, sensory feedback, prosthetic control, neural-machine interface, electrically evoked potentials, whiskers, sensory afferents
MeSH terms
Amputation, Surgical, Animals, Brain Mapping, Forelimb, Male, Median Nerve, Neuronal Plasticity, Somatosensory Cortex, Rats, Sprague-Dawley, Rats

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