The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Endogenous Neurogenesis Replaces Oligodendrocytes and Astrocytes after Primate Spinal Cord Injury
Open accessAbstract
Neurogenesis has been described in various regions of the CNS throughout life. We examined the extent of natural cell division and replacement from 7 weeks to 7 months after cervical spinal cord injury in four adult rhesus monkeys. Bromodeoxyuridine (BrdU) injections revealed an increase of >80-fold in the number of newly divided cells in the primate spinal cord after injury, with an average of 725,000 BrdU-labeled cells identified per monkey in the immediate injury zone. By 7 months after injury, 15% of these new cells expressed mature markers of oligodendrocytes and 12% expressed mature astrocytic markers. Newly born oligodendrocytes were present in zones of injury-induced demyelination and appeared to ensheath or remyelinate host axons. Thus, cell replacement is an extensive natural compensatory response to injury in the primate spinal cord that contributes to neural repair and is a potential target for therapeutic enhancement.
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Citations
Cites
Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys
Crowe, M. J., Bresnahan, J. C., Shuman, S. L., Masters, J. N., & Beattie, M. S. (1997) · Nature Medicine · doi:10.1038/nm0197-73 · Cited by 1,153
McTigue, D. M., Wei, P., & Stokes, B. T. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03392.2001 · Cited by 423
Cell proliferation and replacement following contusive spinal cord injury
Zai, L. J., & Wrathall, J. R. (2005) · Glia · doi:10.1002/glia.20176 · Cited by 240
Cited by
Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells
Meletis, K., Barnabé-Heider, F., Carlén, M., Evergren, E., Tomilin, N., Shupliakov, O., & Frisén, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060182 · Cited by 666
The life, death, and replacement of oligodendrocytes in the adult CNS
McTigue, D. M., & Tripathi, R. B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05570.x · Cited by 455
Prominent oligodendrocyte genesis along the border of spinal contusion lesions
Tripathi, R., & McTigue, D. M. (2007) · Glia · doi:10.1002/glia.20491 · Cited by 131
Ziv, Y., & Schwartz, M. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.09.004 · Cited by 75
Rabchevsky, A. G., Sullivan, P. G., & Scheff, S. W. (2007) · Glia · doi:10.1002/glia.20508 · Cited by 59
Metadata
- Authors
- Yang, H., Lu, P., McKay, H. M., Bernot, T., Keirstead, H., Steward, O., Gage, F. H., Edgerton, V. R., & Tuszynski, M. H.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-02-22
- Volume
- 26
- Issue
- 8
- Pages
- 2157-2166
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2096823844
- Cited by
- 162
- References
- 3
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yang, H., Lu, P., McKay, H. M., Bernot, T., Keirstead, H., Steward, O., Gage, F. H., Edgerton, V. R., & Tuszynski, M. H. (2006). Endogenous Neurogenesis Replaces Oligodendrocytes and Astrocytes after Primate Spinal Cord Injury. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.4070-05.2005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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