Orchestrating brain-cell renewal: The role of immune cells in adult neurogenesis in health and disease
Abstract
Immune cells and immune molecules have recently been shown to support neurogenesis from neural stem and progenitor cells in the adult brain. This non-classical immune activity takes place constantly under normal physiological conditions and is extended under acute pathological conditions to include the attraction of progenitor cells and induction of neurogenesis in regions of the adult central nervous system (CNS) in which formation of new neurons does not normally occur. We suggest that the immune system should be viewed as a novel player in the adult neural stem cell niche and a coordinator of cell renewal processes after injury. We discuss these notions in light of the well-known facts that both immune-cell activity and cell renewal are inherently limited in the adult CNS and that immune and stem cells provide the body's mechanisms of repair.
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CD4+ T cells are necessary for hippocampal neurogenesis in adult rodents.
“CD4+ T cells are necessary for hippocampal neurogenesis in adult rodents”
From Inflammatory T helper 17 cells promote depression-like behavior in mice (2013) · cites this paper as [29]
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Inflammatory T helper 17 cells promote depression-like behavior in mice
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- Authors
- Ziv, Y., & Schwartz, M.
- Affiliations
- Weizmann Institute of Science (IL)
- Corresponding author
- Schwartz, Michal
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 14
- Issue
- 11
- Pages
- 471-478
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2092644347
- Cited by
- 75
- References
- 6
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 6
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- adult neurogenesis, immune cells, neural stem cells, neural progenitor cells, neuroinflammation, neural stem cell niche, brain injury repair, central nervous system regeneration
- MeSH terms
- Adult, Brain, Brain Diseases, Cell Differentiation, Humans, Immunity, Signal Transduction, Neurogenesis
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