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Characterization of the Kynurenine Pathway in Human Neurons

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Guillemin, Gilles J., Cullen, Karen M., Lim, Chai K., Smythe, George A., Garner, Brett, Kapoor, Vimal, Takikawa, Osamu, Brew, Bruce J.·2007·The Journal of Neuroscience
DOI 10.1523/jneurosci.4101-07.2007
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Abstract

The kynurenine pathway is a major route of l-tryptophan catabolism producing neuroactive metabolites implicated in neurodegeneration and immune tolerance. We characterized the kynurenine pathway in human neurons and the human SK-N-SH neuroblastoma cell line and found that the kynurenine pathway enzymes were variably expressed. Picolinic carboxylase was expressed only in primary and some adult neurons but not in SK-N-SH cells. Because of this difference, SK-N-SH cells were able to produce the excitotoxin quinolinic acid, whereas human neurons produced the neuroprotectant picolinic acid. The net result of kynurenine pathway induction in human neurons is therefore predicted to result in neuroprotection, immune regulation, and tumor inhibition, whereas in SK-N-SH cells, it may result in neurotoxicity, immune tolerance, and tumor promotion. This study represents the first comprehensive characterization of the kynurenine pathway in neurons and the first description of the involvement of the kynurenine pathway as a mechanism for controlling both tumor cell neurotoxicity and persistence.

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Metadata

Authors
Guillemin, G. J., Cullen, K. M., Lim, C. K., Smythe, G. A., Garner, B., Kapoor, V., Takikawa, O., & Brew, B. J.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2007-11-21
Volume
27
Issue
47
Pages
12884-12892
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.4101-07.2007
OpenAlex
W2053806684
Cited by
324
References
4
FWCI
4.06
Type
journal article
Language
en
Open access
hybrid
Licence
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 182 d)

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CoChat. (2026). Citation check: Characterization of the Kynurenine Pathway in Human Neurons. https://app.cochat.ai/papers/10.1523/jneurosci.4101-07.2007
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Guillemin, G. J., Cullen, K. M., Lim, C. K., Smythe, G. A., Garner, B., Kapoor, V., Takikawa, O., & Brew, B. J. (2007). Characterization of the Kynurenine Pathway in Human Neurons. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.4101-07.2007

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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