The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Regionally Specific Human GABA Concentration Correlates with Tactile Discrimination Thresholds
Open accessAbstract
The neural mechanisms underlying variability in human sensory perception remain incompletely understood. In particular, few studies have attempted to investigate the relationship between in vivo measurements of neurochemistry and individuals' behavioral performance. Our previous work found a relationship between GABA concentration in the visual cortex and orientation discrimination thresholds (Edden et al., 2009). In the present study, we used magnetic resonance spectroscopy of GABA and psychophysical testing of vibrotactile frequency thresholds to investigate whether individual differences in tactile frequency discrimination performance are correlated with GABA concentration in sensorimotor cortex. Behaviorally, individuals showed a wide range of discrimination thresholds ranging from 3 to 7.6 Hz around the 25 Hz standard. These frequency discrimination thresholds were significantly correlated with GABA concentration (r= −0.58;p< 0.05) in individuals' sensorimotor cortex, but not with GABA concentration in an occipital control region (r= −0.04). These results demonstrate a link between GABA concentration and frequency discrimination in vivo, and support the hypothesis that GABAergic mechanisms have an important role to play in sensory discrimination.
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Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603
PEST: Efficient Estimates on Probability Functions
Taylor, M. M., & Creelman, C. D. (1967) · The Journal of the Acoustical Society of America · doi:10.1121/1.1910407 · Cited by 1,173
Neuronal correlates of decision-making in secondary somatosensory cortex
Romo, R., Hernández, A., Zainos, A., Lemus, L., & Brody, C. D. (2002) · Nature Neuroscience · doi:10.1038/nn950 · Cited by 387
Tsumoto, T., Eckart, W., & Creutzfeldt, O. D. (1979) · Experimental Brain Research · doi:10.1007/bf00235678 · Cited by 302
Cited by
Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA
Mullins, P. G., McGonigle, D. J., O'Gorman, R. L., Puts, N. A. J., Vidyasagar, R., Evans, C. J., & Edden, R. A. E. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2012.12.004 · Cited by 553
Self-citationReduced GABAergic Action in the Autistic Brain
Robertson, C. E., Ratai, E.-M., & Kanwisher, N. (2016) · Current Biology · doi:10.1016/j.cub.2015.11.019 · Cited by 327
Gaetz, W., Bloy, L., Wang, D. J., Port, R. G., Blaskey, L., Levy, S. E., & Roberts, T. P. L. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.068 · Cited by 267
Reduced GABA and altered somatosensory function in children with autism spectrum disorder
Puts, N. A. J., Wodka, E. L., Harris, A. D., Crocetti, D., Tommerdahl, M., Mostofsky, S. H., & Edden, R. A. E. (2017) · Autism Research · doi:10.1002/aur.1691 · Cited by 265
Self-citationReduced GABA Concentration in Attention-Deficit/Hyperactivity Disorder
Edden, R. A. E., Crocetti, D., Zhu, H., Gilbert, D. L., & Mostofsky, S. H. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2280 · Cited by 264
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Metadata
- Authors
- Puts, N. A. J., Edden, R. A. E., Evans, C. J., McGlone, F., & McGonigle, D. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-11-16
- Volume
- 31
- Issue
- 46
- Pages
- 16556-16560
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2035173503
- Cited by
- 166
- References
- 4
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Puts, N. A. J., Edden, R. A. E., Evans, C. J., McGlone, F., & McGonigle, D. J. (2011). Regionally Specific Human GABA Concentration Correlates with Tactile Discrimination Thresholds. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.4489-11.2011
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