The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Functional Dissociation of the Frontoinsular and Anterior Cingulate Cortices in Empathy for Pain
Open accessAbstract
The frontoinsular cortex (FI) and the anterior cingulate cortex (ACC) are thought to be involved in empathy for others' pain. However, the functional roles of FI and ACC in empathetic responses have not yet been clearly dissociated in previous studies. In this study, participants viewed color photographs depicting human body parts in painful or nonpainful situations and performed either pain judgment (painful/nonpainful) or laterality judgment (left/right) of the body parts. We found that activation of FI, rather than ACC, showed significant increase for painful compared with nonpainful images, regardless of the task requirement. Our data suggest a clear functional dissociation between FI and ACC in which FI is more domain-specific than ACC when processing empathy for pain.
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“Despite significant coactivation, these regions may have distinguishable functions (22, 23)”
From Hyperactive error responses and altered connectivity in ventromedial and frontoinsular cortices in obsessive-compulsive disorder (2011) · cites this paper as [22]
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Cites
Studies of interference in serial verbal reactions
Stroop, J. R. (1935) · Journal of Experimental Psychology · doi:10.1037/h0054651 · Cited by 18,622
Dissociable intrinsic connectivity networks for salience processing and executive control
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How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 4×
“Considering the interoceptive function of the insula (Critchley et al., 2004; Craig, 2009), this process can be achieved through a direct mapping of another person’s physiological state to one’s own internal state in FI and its interconnected sensory regions (Carr et al., 2003; Singer et al., 2009).”
BackgroundInfluentialThresholding of statistical maps in functional neuroimaging using the false discovery rate
Genovese, C. R., Lazar, N. A., & Nichols, T. (2002) · NeuroImage · doi:10.1006/nimg.2001.1037 · Cited by 4,923
Empathy: its ultimate and proximate bases
Preston, S. D., & de Waal, F. B. M. (2002) · Behavioral and Brain Sciences · doi:10.1017/s0140525x02000018 · Cited by 4,126
Empathy for Pain Involves the Affective but not Sensory Components of Pain
Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R. J., & Frith, C. D. (2004) · Science · doi:10.1126/science.1093535 · Cited by 3,929
Frith, C., & Frith, U. (2005) · Current Biology · doi:10.1016/j.cub.2005.08.041 · Cited by 3,561
Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406 · cited 5×
“Considering the interoceptive function of the insula (Critchley et al., 2004; Craig, 2009), this process can be achieved through a direct mapping of another person’s physiological state to one’s own internal state in FI and its interconnected sensory regions (Carr et al.”
BackgroundInfluentialSridharan, D., Levitin, D. J., & Menon, V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800005105 · Cited by 2,892
Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
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Lamm, C., Decety, J., & Singer, T. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.014 · Cited by 2,016
Toward a second-person neuroscience
Schilbach, L., Timmermans, B., Reddy, V., Costall, A., Bente, G., Schlicht, T., & Vogeley, K. (2013) · Behavioral and Brain Sciences · doi:10.1017/s0140525x12000660 · Cited by 1,510
Liu, X., Hairston, J., Schrier, M., & Fan, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.12.012 · Cited by 916
Self-citationBernhardt, B. C., & Singer, T. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150536 · Cited by 952
Anterior insular cortex and emotional awareness
Gu, X., Hof, P. R., Friston, K. J., & Fan, J. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23368 · Cited by 712
“In the current review, we simplify this definition as the conscious experience of emotions (the experiential or “feeling” domain of emotion); operationally, emotional awareness occurs during the supraliminal processing of affective stimuli (Pessoa, 2005).”
InfluentialSelf-citation
Metadata
- Authors
- Gu, X., Liu, X., Guise, K. G., Naidich, T. P., Hof, P. R., & Fan, J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Fan, Jin
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-03-10
- Volume
- 30
- Issue
- 10
- Pages
- 3739-3744
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2845539
- OpenAlex
- W2109880731
- Cited by
- 150
- References
- 38
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 5 · 2023: 8 · 2022: 10 · 2021: 8 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 15 · 2014: 15 · 2013: 20 · 2012: 18
- FWCI
- 23.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- James S. McDonnell Foundation (22002078)
- National Institutes of Health
- National Institute of Mental Health (MH083164, R21MH083164)
- National Center for Research Resources (MO1RR00071, M01RR000071)
- Topics
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- empathy for pain, frontoinsular cortex, anterior cingulate cortex, functional dissociation, pain perception, domain specificity, mirror neuron system
- MeSH terms
- Adult, Brain Mapping, Cerebral Cortex, Empathy, Female, Frontal Lobe, Gyrus Cinguli, Humans, Male, Pain, Pain Measurement, Photic Stimulation, Pilot Projects, Young Adult
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