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Functional Dissociation of the Frontoinsular and Anterior Cingulate Cortices in Empathy for Pain
Open accessAbstract
The frontoinsular cortex (FI) and the anterior cingulate cortex (ACC) are thought to be involved in empathy for others' pain. However, the functional roles of FI and ACC in empathetic responses have not yet been clearly dissociated in previous studies. In this study, participants viewed color photographs depicting human body parts in painful or nonpainful situations and performed either pain judgment (painful/nonpainful) or laterality judgment (left/right) of the body parts. We found that activation of FI, rather than ACC, showed significant increase for painful compared with nonpainful images, regardless of the task requirement. Our data suggest a clear functional dissociation between FI and ACC in which FI is more domain-specific than ACC when processing empathy for pain.
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“Despite significant coactivation, these regions may have distinguishable functions (22, 23)”
From Hyperactive error responses and altered connectivity in ventromedial and frontoinsular cortices in obsessive-compulsive disorder (2011) · cites this paper as [22]
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Metadata
- Authors
- Gu, X., Liu, X., Guise, K. G., Naidich, T. P., Hof, P. R., & Fan, J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Fan, Jin
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-03-10
- Volume
- 30
- Issue
- 10
- Pages
- 3739-3744
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2845539
- OpenAlex
- W2109880731
- Cited by
- 150
- References
- 38
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 5 · 2023: 8 · 2022: 10 · 2021: 8 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 15 · 2014: 15 · 2013: 20 · 2012: 18
- FWCI
- 23.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- James S. McDonnell Foundation (22002078)
- National Institutes of Health
- National Institute of Mental Health (MH083164, R21MH083164)
- National Center for Research Resources (MO1RR00071, M01RR000071)
- Topics
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- empathy for pain, frontoinsular cortex, anterior cingulate cortex, functional dissociation, pain perception, domain specificity, mirror neuron system
- MeSH terms
- Adult, Brain Mapping, Cerebral Cortex, Empathy, Female, Frontal Lobe, Gyrus Cinguli, Humans, Male, Pain, Pain Measurement, Photic Stimulation, Pilot Projects, Young Adult
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