The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
TRPV1 Is Activated by Both Acidic and Basic pH
Open accessAbstract
Maintaining physiological pH is required for survival, and exposure to alkaline chemicals such as ammonia (smelling salts) elicits severe pain and inflammation through unknown mechanisms. TRPV1, the capsaicin receptor, is an integrator of noxious stimuli including heat and extracellular acidic pH. Here, we report that ammonia activates TRPV1, TRPA1 (another polymodal nocisensor), and other unknown receptor(s) expressed in sensory neurons. Ammonia and intracellular alkalization activate TRPV1 through a mechanism that involves a cytoplasmic histidine residue, not used by other TRPV1 agonists such as heat, capsaicin or low pH. Our studies show that TRPV1 detects both acidic and basic deviations from homeostatic pH.
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Cites
Impaired nociception and pain sensation in mice lacking the capsaicin receptor
Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Basbaum, A. I., & Julius, D. (2000) · Science · doi:10.1126/science.288.5464.306 · Cited by 3,544
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., & Julius, D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80564-4 · Cited by 3,081
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T. R., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00158-2 · Cited by 2,486
Self-citationKwan, K. Y., Allchorne, A. J., Vollrath, M. A., Christensen, A. P., Zhang, D.-S., Woolf, C. J., & Corey, D. P. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.042 · Cited by 1,267
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
Macpherson, L. J., Dubin, A. E., Evans, M. J., Marr, F., Schultz, P. G., Cravatt, B. F., & Patapoutian, A. (2007) · Nature · doi:10.1038/nature05544 · Cited by 1,116
Self-citationTRP channel activation by reversible covalent modification
Hinman, A., Chuang, H.-H., Bautista, D. M., & Julius, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609598103 · Cited by 890
Trp ion channels and temperature sensation
Dhaka, A., Viswanath, V., & Patapoutian, A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112958 · Cited by 782
Self-citationWhole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel
Kirichok, Y., Navarro, B., & Clapham, D. E. (2006) · Nature · doi:10.1038/nature04417 · Cited by 461
The Ankyrin Repeats of TRPV1 Bind Multiple Ligands and Modulate Channel Sensitivity
Lishko, P. V., Procko, E., Jin, X., Phelps, C. B., & Gaudet, R. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.027 · Cited by 447
More than cool: Promiscuous relationships of menthol and other sensory compounds
Macpherson, L. J., Hwang, S. W., Miyamoto, T., Dubin, A. E., Patapoutian, A., & Story, G. M. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.05.005 · Cited by 401
Self-citation
Cited by
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not
Romanovsky, A. A., Almeida, M. C., Garami, A., Steiner, A. A., Norman, M. H., Morrison, S. F., Nakamura, K., Burmeister, J. J., & Nucci, T. B. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001263 · Cited by 253
TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision
Ryskamp, D., Redmon, S., Jo, A., & Križaj, D. (2014) · Cells · doi:10.3390/cells3030914 · Cited by 60
Periglomerular afferent innervation of the mouse renal cortex
Tyshynsky, R., Sensarma, S., Riedl, M., Bukowy, J., Schramm, L. P., Vulchanova, L., & Osborn, J. W. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.974197 · Cited by 21
Metadata
- Authors
- Dhaka, A., Uzzell, V., Dubin, A. E., Mathur, J., Petrus, M., Bandell, M., & Patapoutian, A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-01-07
- Volume
- 29
- Issue
- 1
- Pages
- 153-158
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1967863888
- Cited by
- 252
- References
- 18
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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