TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision
Open accessAbstract
Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids. While originally reported to serve as a pain and heat detector in the peripheral nervous system, TRPV1 has been implicated in the modulation of blood flow and osmoregulation but also neurotransmission, postsynaptic neuronal excitability and synaptic plasticity within the central nervous system. In addition to its central role in nociception, evidence is accumulating that TRPV1 contributes to stimulus transduction and/or processing in other sensory modalities, including thermosensation, mechanotransduction and vision. For example, TRPV1, in conjunction with intrinsic cannabinoid signaling, might contribute to retinal ganglion cell (RGC) axonal transport and excitability, cytokine release from microglial cells and regulation of retinal vasculature. While excessive TRPV1 activity was proposed to induce RGC excitotoxicity, physiological TRPV1 activity might serve a neuroprotective function within the complex context of retinal endocannabinoid signaling. In this review we evaluate the current evidence for localization and function of TRPV1 channels within the mammalian retina and explore the potential interaction of this intriguing nociceptor with endogenous agonists and modulators.
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Supraspinal TRPV1 activation induces anti-nociception, contrary to peripheral TRPV1 activation which induces nociception, hyperalgesia, and pain transduction modulation.
“Contrary to the periphery, where activated TRPV1 induces nociception, hyperalgesia, and pain transduction modulation,47 supraspinal TRPV1 activation induces anti-nociception.37,45,48”
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TRPV1 activation stimulates NKCC1 and increases hydrostatic pressure in the mouse lens
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- Authors
- Ryskamp, D., Redmon, S., Jo, A., & Križaj, D.
- Affiliations
- Department of Ophthalmology & Visual Sciences, Moran Eye Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
- University of Utah (US)
- Corresponding author
- Križaj, David
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2014-09-12
- Volume
- 3
- Issue
- 3
- Pages
- 914-938
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC4197638
- OpenAlex
- W2050410855
- Cited by
- 60
- References
- 166
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 2 · 2020: 11 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 6 · 2014: 2
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Eye Institute (RO1 EY022076)
- NEI (P30 EY014800)
- NIH (T32DC008553)
- U.S. Department of Defense (W81XWH-12-1-0244)
- HHMI (Med into Grad scholarship)
- University of Utah (Undergraduate Research Opportunity Program)
- State of Utah (TCIP award)
- Glaucoma Research Foundation
- Research to Prevent Blindness (unrestricted grant to the Moran Eye Institute)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- TRPV1, endocannabinoids, retinal ganglion cells, vision, nociception, thermosensation, mechanotransduction, retinal vasculature, microglia, axonal transport, excitotoxicity, neuroprotection, cannabinoid signaling, sensory transduction
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