Cited by 118Amino Acid Enzymes and MetabolismNeuroscience and Neuropharmacology ResearchTryptophan and brain disorders

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

D-Serine in Glia and Neurons Derives from 3-Phosphoglycerate Dehydrogenase

Open access

Ehmsen, J. T., Ma, T. M., Sason, H., Rosenberg, D., Ogo, T., Furuya, S., Snyder, S. H., Wolosker, H.·2013·Journal of Neuroscience

DOI 10.1523/jneurosci.4914-12.2013PMC PMC3721849

Open this paper in CoChat — free account Open PDF

Abstract

d-Serine is an endogenous ligand for NMDARs generated from l-serine by the enzyme serine racemase (Srr). Both neuronal and glial localizations have been reported for d-serine and Srr. 3-Phosphoglycerate dehydrogenase is an exclusively astrocytic enzyme that catalyzes the first committed step of l-serine biosynthesis. Using transgenic mice expressing enhanced green fluorescent protein under the Srr promoter and mice with targeted deletion of Srr or 3-Phosphoglycerate dehydrogenase, we demonstrate predominantly neuronal sources of d-serine dependent on astrocytic supply of l-serine. These findings clarify the cellular basis for the regulation of NMDAR neurotransmission by d-serine.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.4914-12.2013

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

NIH Image to ImageJ: 25 years of image analysis
Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.
Mothet, J., Parent, A., Wolosker, H., Brady, R., Linden, D. J., Ferris, C., Rogawski, M., & Snyder, S. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.97.9.4926 · Cited by 1,164
Production and purification of lentiviral vectors
Tiscórnia, G., Singer, O., & Verma, I. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.37 · Cited by 974
Glia-Derived d-Serine Controls NMDA Receptor Activity and Synaptic Memory
Panatier, A., Theodosis, D. T., Mothet, J.-P., Touquet, B., Pollegioni, L., Poulain, D. A., & Oliet, S. H. R. (2006) · Cell · doi:10.1016/j.cell.2006.02.051 · Cited by 934
D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release
Schell, M. J., Molliver, M. E., & Snyder, S. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3948 · Cited by 832
Serine racemase: A glial enzyme synthesizing d -serine to regulate glutamate- N -methyl- d -aspartate neurotransmission
Wolosker, H., Blackshaw, S., & Snyder, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13409 · Cited by 811
Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists
Papouin, T., Ladépêche, L., Ruel, J., Sacchi, S., Labasque, M., Hanini, M., Groc, L., Pollegioni, L., Mothet, J., & Oliet, S. H. R. (2012) · Cell · doi:10.1016/j.cell.2012.06.029 · Cited by 798
Purification of serine racemase: biosynthesis of the neuromodulator D-serine.
Wolosker, H., Sheth, K., Takahashi, M., Mothet, J., Brady, R., Ferris, C., & Snyder, S. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.2.721 · Cited by 505
NMDA receptors in clinical neurology: excitatory times ahead
Kalia, L. V., Kalia, S. K., & Salter, M. W. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70165-0 · Cited by 421
d-Serine as a Neuromodulator: Regional and Developmental Localizations in Rat Brain Glia Resemble NMDA Receptors
Schell, M. J., Brady Jr., R. O., Molliver, M. E., & Snyder, S. H. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01604.1997 · Cited by 415 · cited 3×
“D-Serine localized to neurons and astrocytes As with Srr, reports of D-serine localizations have varied with descriptions of astrocytic (Schell et al., 1997; Kartvelishvily et al., 2006; Williams et al., 2006) and neuronal (Kartvelishvily et al., 2006) sites.”
BackgroundSelf-citation

Show all 27 references

Sorted by citations

Astrocyte-neuron metabolic cooperation shapes brain activity
Bonvento, G., & Bolaños, J. P. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.006 · Cited by 580
Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway
Morizawa, Y. M., Hirayama, Y., Ohno, N., Shibata, S., Shigetomi, E., Sui, Y., Nabekura, J., Sato, K., Okajima, F., Takebayashi, H., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00037-1 · Cited by 424
Glutamate hypothesis in schizophrenia
Uno, Y., & Coyle, J. T. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12823 · Cited by 389
Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism
Yellen, G. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201803152 · Cited by 371
“…cancer cells, astrocytes perform glycolysis not primarily for energy but rather for anabolic biosynthesis: For instance, astrocytes and not neurons express the phosphoglycerate dehydrogenase involved in serine biosynthesis (Ehmsen et al., 2013), which branches off of the main glycolytic pathway.”
Background
Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease
Douce, J. L., Maugard, M., Veran, J., Matos, M., Jégo, P., Vigneron, P.-A., Faivre, É., Toussay, X., Vandenberghe, M. E., Balbastre, Y., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.004 · Cited by 336
Neurons release serine to support mRNA translation in pancreatic cancer
Banh, R. S., Biancur, D. E., Yamamoto, K., Sohn, A. S. W., Walters, B., Kuljanin, M., Gikandi, A., Wang, H., Mancias, J. D., Schneider, R. J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.016 · Cited by 292
The NMDA Receptor and Schizophrenia
Balu, D. T. (2016) · Advances in pharmacology · doi:10.1016/bs.apha.2016.01.006 · Cited by 303
Deciphering the astrocyte reaction in Alzheimer's disease
Perez-Nievas, B. G., & Serrano-Pozo, A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00114 · Cited by 282
An overview on d-amino acids
Genchi, G. (2017) · Amino Acids · doi:10.1007/s00726-017-2459-5 · Cited by 288
The NMDA receptor ‘glycine modulatory site’ in schizophrenia: d-serine, glycine, and beyond
Balu, D. T., & Coyle, J. T. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.12.004 · Cited by 208
The Rise and Fall of the d -Serine-Mediated Gliotransmission Hypothesis
Wolosker, H., Balu, D. T., & Coyle, J. T. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.09.007 · Cited by 198
Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells
Liu, Y., Shen, X. P., Zhang, Y., Zheng, X., Cepeda, C., Wang, Y., Duan, S., & Tong, X. (2023) · Glia · doi:10.1002/glia.24343 · Cited by 199
Brain energy metabolism: Astrocytes in neurodegenerative diseases.
Chen, Z., Yuan, Z., Yang, S., Zhu, Y., Xue, M., Zhang, J., & Leng, L. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13982 · Cited by 153
Astrocytes as Guardians of Neuronal Excitability: Mechanisms Underlying Epileptogenesis
Verhoog, Q. P., Holtman, L., Aronica, E., & van Vliet, E. A. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.591690 · Cited by 149
The NMDA receptor activation by d -serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle
Neame, S., Safory, H., Radzishevsky, I. S., Touitou, A., Marchesani, F., Marchetti, M., Kellner, S., Berlin, S., Foltyn, V. N., Engelender, S., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909458116 · Cited by 151
Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus
Bail, M. L., Martineau, M., Sacchi, S., Yatsenko, N., Radzishevsky, I. S., Conrod, S., Ouares, K. A., Wolosker, H., Pollegioni, L., Billard, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416668112 · Cited by 155
A critical review on serine protease: Key immune manipulator and pathology mediator
Patel, S. V. (2017) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2016.10.011 · Cited by 150
Astroglial correlates of neuropsychiatric disease: From astrocytopathy to astrogliosis
Kim, R., Healey, K. L., Sepulveda-Orengo, M. T., & Reissner, K. J. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.10.002 · Cited by 154
d-Serine and Serine Racemase are Localized to Neurons in the Adult Mouse and Human Forebrain
Balu, D. T., Takagi, S., Puhl, M. D., Benneyworth, M. A., & Coyle, J. T. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0027-z · Cited by 126
ASCT1 (Slc1a4) transporter is a physiologic regulator of brain d -serine and neurodevelopment
Kaplan, E., Zubedat, S., Radzishevsky, I. S., Valenta, A. C., Rechnitz, O., Sason, H., Sajrawi, C., Bodner, O., Konno, K., Esaki, K., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722677115 · Cited by 124
Contribution of Astroglial Cx43 Hemichannels to the Modulation of Glutamatergic Currents by D-Serine in the Mouse Prefrontal Cortex
Meunier, C. N. J., Wang, N., Yi, C., Dallérac, G. M., Ezan, P., Koulakoff, A., Leybaert, L., & Giaume, C. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2204-16.2017 · Cited by 115
Cell-type specific mechanisms of D-serine uptake and release in the brain
Martineau, M., Parpura, V., & Mothet, J. (2014) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2014.00012 · Cited by 116
Astroglial versus Neuronal D-Serine: Fact Checking
Papouin, T., Henneberger, C., Rusakov, D. A., & Oliet, S. H. R. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.05.007 · Cited by 103
l-Serine Deficiency Elicits Intracellular Accumulation of Cytotoxic Deoxysphingolipids and Lipid Body Formation
Esaki, K., Sayano, T., Sonoda, C., Akagi, T., Suzuki, T., Ogawa, T., Okamoto, M., Yoshikawa, T., Hirabayashi, Y., & Furuya, S. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.603860 · Cited by 100
Time and space profiling of NMDA receptor co‐agonist functions
Mothet, J., Bail, M. L., & Billard, J. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13204 · Cited by 103
Hemichannels: new roles in astroglial function
Orellana, J. A., & Stehberg, J. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00193 · Cited by 100
d-Serine as the gatekeeper of NMDA receptor activity: implications for the pharmacologic management of anxiety disorders
Wolosker, H., & Balu, D. T. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00870-x · Cited by 106
D-Amino Acids in the Nervous and Endocrine Systems
Kiriyama, Y., & Nochi, H. (2016) · Scientifica · doi:10.1155/2016/6494621 · Cited by 99
D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures
Foster, A. C., Farnsworth, J. C., Lind, G. E., Li, Y.-X., Yang, J., Dang, V., Penjwini, M., Viswanath, V., Staubli, U. V., & Kavanaugh, M. P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156551 · Cited by 90
Revisiting enigmatic cortical calretinin-expressing interneurons
Cauli, B., Zhou, X., Tricoire, L., Toussay, X., & Staiger, J. F. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00052 · Cited by 86
The serine shuttle between glia and neurons: implications for neurotransmission and neurodegeneration
Wolosker, H., & Radzishevsky, I. S. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130220 · Cited by 86
D-3-Phosphoglycerate Dehydrogenase
Grant, G. A. (2018) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2018.00110 · Cited by 84
d-Serine, the Shape-Shifting NMDA Receptor Co-agonist
Coyle, J. T., Balu, D. T., & Wolosker, H. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03014-1 · Cited by 71
Asc-1 Transporter Regulation of Synaptic Activity via the Tonic Release of d-Serine in the Forebrain
Sason, H., Billard, J. M., Smith, G. P., Safory, H., Neame, S., Kaplan, E., Rosenberg, D., Zubedat, S., Foltyn, V. N., Christoffersen, C. T., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhv350 · Cited by 74
The Neurobiology of d -Serine Signaling
Wolosker, H. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.08.010 · Cited by 69
Cortical maps: a role for astrocytes?
López-Hidalgo, M. A., & Schummers, J. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.11.001 · Cited by 59
Astroglial Versus Neuronal D-Serine: Check Your Controls!
Wolosker, H., Balu, D. T., & Coyle, J. T. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.06.010 · Cited by 56
Distinctive Roles of D-Amino Acids in the Homochiral World: Chirality of Amino Acids Modulates Mammalian Physiology and Pathology
Sasabe, J., & Suzuki, M. (2018) · The Keio Journal of Medicine · doi:10.2302/kjm.2018-0001-ir · Cited by 54
Presymptomatic Increase of an Extracellular RNA in Blood Plasma Associates with the Development of Alzheimer’s Disease
Yan, Z., Zhou, Z., Wu, Q., Chen, Z. B., Koo, E. H., & Zhong, S. (2020) · Current Biology · doi:10.1016/j.cub.2020.02.084 · Cited by 55
Postsynaptic Serine Racemase Regulates NMDA Receptor Function
Wong, J. M., Folorunso, O. O., Barragan, E. V., Berciu, C., Harvey, T. L., DeChellis-Marks, M. R., Glausier, J. R., MacDonald, M. L., Coyle, J. T., Balu, D. T., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1525-20.2020 · Cited by 52
d ‐amino acids: new functional insights
Pollegioni, L., Kuštrimović, N. Z., Piubelli, L., Rosini, E., Rabattoni, V., & Sacchi, S. (2025) · FEBS Journal · doi:10.1111/febs.70083 · Cited by 55
D-Serine Signaling and NMDAR-Mediated Synaptic Plasticity Are Regulated by System A-Type of Glutamine/D-Serine Dual Transporters
Bodner, O., Radzishevsky, I., Foltyn, V. N., Touitou, A., Valenta, A. C., Rangel, I. F., Panizzutti, R., Kennedy, R. T., Billard, J. M., & Wolosker, H. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.0801-20.2020 · Cited by 49
Self-citation
Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS
Beltrán-Castillo, S., Eugenín, J. L., & Rommy von Bernhardi, M. (2018) · Mediators of Inflammation · doi:10.1155/2018/7219732 · Cited by 50
Glycolytic flux controls d -serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes
Suzuki, M., Sasabe, J., Miyoshi, Y., Kuwasako, K., Muto, Y., Hamase, K., Matsuoka, M., Imanishi, N., & Aiso, S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416117112 · Cited by 54
Two new cases of serine deficiency disorders treated with l-serine
Brassier, A., Valayannopoulos, V., Bahi‐Buisson, N., Wiame, E., Hubert, L., Boddaert, N., Kamińska, A., Habarou, F., Desguerre, I., SCHAFTINGEN, E. V., et al. (2015) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2015.10.007 · Cited by 47
D-Serine and Serine Racemase Are Associated with PSD-95 and Glutamatergic Synapse Stability
Lin, H., Jacobi, A. A., Anderson, S. A., & Lynch, D. R. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00034 · Cited by 47
Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR‐dependent transmission and short‐term fear memory in the basolateral amygdala
Linsambarth, S., Carvajal, F. J., Moraga‐Amaro, R., Mendez, L., Tamburini, G., Jiménez-Dinamarca, I., Verdugo, D. A., Gómez, G. I., Jury, N., Martínez, P., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202100798rr · Cited by 41
Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer’s disease
Agostini, A., Ding, Y., Bai, L., Kendall, D. A., & Pardon, M. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.019 · Cited by 43
Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain
Choi, S., Moon, J.-Y., Roh, D., Yoon, S. Y., Kwon, S. G., Choi, H., Kang, S.-Y., Han, H., Beitz, A. J., & Lee, J. (2016) · Journal of Pain · doi:10.1016/j.jpain.2016.12.002 · Cited by 40
Imaging and spectroscopic approaches to probe brain energy metabolism dysregulation in neurodegenerative diseases
Bonvento, G., Valette, J., Flament, J., Mochel, F., & Brouillet, E. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17697989 · Cited by 38
The Gliotransmitter d-Serine Promotes Synapse Maturation and Axonal Stabilization In Vivo
Horn, M. R. V., Strasser, A., Miraucourt, L. S., Pollegioni, L., & Ruthazer, E. S. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3158-16.2017 · Cited by 43
Serine Racemase and D-serine in the Amygdala Are Dynamically Involved in Fear Learning
Balu, D. T., Presti, K. T., Huang, C. C., Muszynski, K., Radzishevsky, I. S., Wolosker, H., Guffanti, G., Ressler, K. J., & Coyle, J. T. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.012 · Cited by 38
Novel insight into astrocyte-mediated gliotransmission modulates the synaptic plasticity in major depressive disorder
Lei, L., Wang, Y., Chen, C.-Y., Wang, Y., & Zhang, Y. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122988 · Cited by 38
The plastic d-serine signaling pathway: Sliding from neurons to glia and vice-versa
Ivanov, A. D., & Mothet, J. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.05.039 · Cited by 37
Investigating brain d ‐serine: Advocacy for good practices
Mothet, J., Billard, J., Pollegioni, L., Coyle, J. T., & Sweedler, J. V. (2019) · Acta Physiologica · doi:10.1111/apha.13257 · Cited by 36
Neural Metabolic Networks: Key Elements of Healthy Brain Function
Madrer, N., Perera, N. D., Uccelli, N. A., Abbondanza, A., Andersen, J. V., Carsana, E. V., Demmings, M. D., Fernandez, R. F., de Fragas, M. G., Gbadamosi, I., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70084 · Cited by 37
A comprehensive review on signaling attributes of serine and serine metabolism in health and disease
Wu, D., Zhang, K., Khan, F. A., Pandupuspitasari, N. S., Guan, K., Sun, F., & Huang, C. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129607 · Cited by 35
D-Amino acids from foods and gut microbiota and their effects in health and disease
Roskjær, A. B., Roager, H. M., & Dragsted, L. O. (2024) · Food Reviews International · doi:10.1080/87559129.2024.2347472 · Cited by 35
The role of astrocytes in depression, its prevention, and treatment by targeting astroglial gliotransmitter release
Duarte, Y., Quintana-Donoso, D., Moraga‐Amaro, R., Jiménez-Dinamarca, I., Lemunao-Inostroza, Y., Cárdenas, K., Bahamonde, T., Barrientos, T., Olivares, P., Navas, C., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2307953121 · Cited by 35
NMDARs, Coincidence Detectors of Astrocytic and Neuronal Activities
Sherwood, M. W., Oliet, S. H. R., & Panatier, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147258 · Cited by 29
Not Just a Bystander: The Emerging Role of Astrocytes and Research Tools in Studying Cognitive Dysfunctions in Schizophrenia
Chang, C., Luo, D.-Z., Pei, J.-C., Kuo, M., Hsieh, Y., & Lai, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105343 · Cited by 29
Serine racemase: a key player in apoptosis and necrosis
Canu, N., Ciotti, M. T., & Pollegioni, L. (2014) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2014.00009 · Cited by 29
Changes in Serine Racemase-Dependent Modulation of NMDA Receptor: Impact on Physiological and Pathological Brain Aging
Billard, J. (2018) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2018.00106 · Cited by 28
D-Serine Contributes to Seizure Development via ERK Signaling
Ma, T., Wu, Y., Chen, B., Zhang, W., Jin, L., Shen, C., Wang, Y., & Liu, Y. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00254 · Cited by 27
Phenylglycine analogs are inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 and enhance NMDA receptor-mediated LTP in rat visual cortex slices
Foster, A. C., Rangel-Diaz, N., Staubli, U. V., Yang, J., Penjwini, M., Viswanath, V., & Li, Y. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.08.010 · Cited by 27
Tonic NMDA Receptor Currents in the Brain: Regulation and Cognitive Functions
Kim, H., Choi, S., Lee, E., Koh, W., & Lee, C. J. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.03.009 · Cited by 26
A connectomics approach to understanding a retinal disease
Zucker, C. L., Bernstein, P. S., Schalek, R. L., Lichtman, J. W., & Dowling, J. E. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011532117 · Cited by 25
Nuclear Compartmentalization of Serine Racemase Regulates d-Serine Production
Kolodney, G., Dumin, E., Safory, H., Rosenberg, D., Mori, H., Radzishevsky, I. S., & Wolosker, H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.699496 · Cited by 24
Increased excitation-inhibition balance and loss of GABAergic synapses in the serine racemase knockout model of NMDA receptor hypofunction
Jami, S. A., Cameron, S., Wong, J. M., Daly, E. R., McAllister, A. K., & Gray, J. A. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00661.2020 · Cited by 25
ASC Transporters Mediate D-Serine Transport into Astrocytes Adjacent to Synapses in the Mouse Brain
Krishnan, K. S., & Billups, B. (2023) · Biomolecules · doi:10.3390/biom13050819 · Cited by 23
Cellular Origin and Regulation of D -and L -Serine in in Vitro and in Vivo Models of Cerebral Ischemia
Abe, T., Suzuki, M., Sasabe, J., Takahashi, S., Unekawa, M., Mashima, K., Iizumi, T., Hamase, K., Konno, R., Aiso, S., et al. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.164 · Cited by 21
Regenerative potential of the brain: Composition and forming of regulatory microenvironment in neurogenic niches
Komleva, Y. K., Kuvacheva, N. V., Malinocskaya, N. A., Gorina, Y. V., Lopatina, O. L., Тепляшина, Е. А., Пожиленкова, Е. А., Zamay, A. S., Morgun, A. V., & Salmina, A. B. (2016) · Human Physiology · doi:10.1134/s0362119716080077 · Cited by 19
Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity
Tutas, J., Tolve, M., Ozer, E., Ickert, L., Klein, I., Silverman, Q., Liebsch, F., Dethloff, F., Giavalisco, P., Endepols, H., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01196-4 · Cited by 20
A structural view onto disease-linked mutations in the human neutral amino acid exchanger ASCT1
Stehantsev, P., Stetsenko, A., Nemchinova, M., Aduri, N. G., Marrink, S., Gati, C., & Guskov, A. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.09.015 · Cited by 18
FBXO22 Protein Is Required for Optimal Synthesis of the N-Methyl-d-Aspartate (NMDA) Receptor Coagonist d-Serine
Dikopoltsev, E., Foltyn, V. N., Zehl, M., Jensen, O. N., Mori, H., Radzishevsky, I. S., & Wolosker, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.618405 · Cited by 17
Algorithmic reconstruction of glioblastoma network complexity
Uthamacumaran, A., & Craig, M. (2022) · iScience · doi:10.1016/j.isci.2022.104179 · Cited by 15
Serine Racemase Expression Differentiates Aging from Alzheimer’s Brain
Wu, S., Zhou, J., Zhang, H., & Barger, S. W. (2022) · Current Alzheimer Research · doi:10.2174/1567205019666220805105106 · Cited by 14
Neuronal serine racemase associates with Disrupted-In-Schizophrenia-1 and DISC1 agglomerates: Implications for schizophrenia
Jacobi, A. A., Halawani, S. M., Lynch, D. R., & Lin, H. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.10.055 · Cited by 12
D-serine in the midbrain periaqueductal gray contributes to morphine tolerance in rats
Cao, S., Xiao, Z., Sun, M.-J., & Li, Y. (2016) · Molecular Pain · doi:10.1177/1744806916646786 · Cited by 13
The Emerging Role of Amino Acids of the Brain Microenvironment in the Process of Metastasis Formation
Cutruzzolà, F., Bouzidi, A., Liberati, F. R., Spizzichino, S., Boumis, G., Macone, A., Rinaldo, S., Giardina, G., & Paone, A. (2021) · Cancers · doi:10.3390/cancers13122891 · Cited by 12
Serine Racemase mediates subventricular zone neurogenesis via fatty acid metabolism
Roychaudhuri, R., Atashi, H., & Snyder, S. H. (2023) · Stem Cell Reports · doi:10.1016/j.stemcr.2023.05.015 · Cited by 15
Clinical histopathology and pathogenesis of macular telangiectasia type 2
Ntentakis, D. P., Ntentaki, A. M., Delavogia, E., Sakuno, G., Correa, V., Efstathiou, N. E., Aronow, M. E., Chew, E. Y., Miller, J. W., & Vavvas, D. G. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101401 · Cited by 13
Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution
Schaeffer, S. M., Pacholko, A. G., Santisteban, M. M., Ahn, S. J., Racchumi, G., Wang, G., Park, L., Faraco, G., Anrather, J., & Iadecola, C. (2025) · Neuron · doi:10.1016/j.neuron.2025.10.018 · Cited by 14
SLC1A4 and Serine Homeostasis: Implications for Neurodevelopmental and Neurodegenerative Disorders
Elazar, D., Alvarez, N., Drobeck, S., & Gunn, T. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052104 · Cited by 10
Proteomic profiling reveals dopaminergic regulation of progenitor cell functions of goldfish radial glial cells in vitro
Xing, L., Martyniuk, C. J., Esau, C., Fonte, D. F. D., & Trudeau, V. L. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.05.003 · Cited by 10
Differential regulation of NMDA receptors by d -serine and glycine in mammalian spinal locomotor networks
Acton, D. G., & Miles, G. B. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00810.2016 · Cited by 10
Pre-operative cellularity mapping and intra-MRI surgery: potential for improving neurosurgical biopsies
Chen, C. C., White, N. S., Farid, N., Kobalka, P. J., Hansen, L. A., Pearn, M. L., & Dale, A. M. (2014) · Expert Review of Medical Devices · doi:10.1586/17434440.2015.975118 · Cited by 8
Proteomic profile differentiating between mesial temporal lobe epilepsy with and without hippocampal sclerosis
Furukawa, A., Kakita, A., Chiba, Y., Kitaura, H., Fujii, Y., Fukuda, M., Kameyama, S., & Shimada, A. (2020) · Epilepsy Research · doi:10.1016/j.eplepsyres.2020.106502 · Cited by 8
Serine Racemase Expression by Striatal Neurons
Takagi, S., Puhl, M. D., Anderson, T., Balu, D. T., & Coyle, J. T. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00880-9 · Cited by 8
Dynamic regulation of d ‐serine release in the vertebrate retina
Gustafson, E. C., Stevens, E. S., & Miller, R. F. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.283432 · Cited by 6
Gliotransmission in physiologic and pathologic conditions
Cheong, E., & Lee, C. J. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19104-6.00003-6 · Cited by 6
High-throughput ultrastructural analysis of macular telangiectasia type 2
Zucker, C. L., Bernstein, P. S., Schalek, R. L., Lichtman, J. W., & Dowling, J. E. (2024) · Frontiers in Ophthalmology · doi:10.3389/fopht.2024.1428777 · Cited by 4
Amygdala astrocyte senescence drives stress-induced anxiety and hyperglycemia
He, A., Zhu, Y., Liang, C., Huang, S., Yuan, Z., Yang, S., Chen, Y., Can, D., Lei, A., Li, H., et al. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.03.006 · Cited by 3
Serine Metabolic Networks in Plants
Rosa‐Téllez, S., Casatejada‐Anchel, R., Alcántara‐Enguídanos, A., Torres‐Moncho, A., Dohgri, M., Martínez-Serra, C., Nebauer, S. G., Arrillaga, I., Renau‐Morata, B., Muñoz‐Bertomeu, J., et al. (2023) · Progress in botany · doi:10.1007/124_2023_73 · Cited by 3
D-Serine agonism of GluN1-GluN3 NMDA receptors regulates the activity of enteric neurons and coordinates gut motilityPreprint
Osorio, N., Martineau, M., Fortea, M., Rouget, C., Pénalba, V., Lee, C. J., Boesmans, W., Rolli‐Derkinderen, M., Patel, A. V., Mondielli, G., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.19.537136 · Cited by 3
d-Serine’s Journey Between Stars and Synapses
Mountadem, S., Oliet, S. H. R., & Panatier, A. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04564-y · Cited by 2
Physiological Roles of d-Serine in the Central Nervous System
Mothet, J., Mondielli, G., & Martineau, M. (2016) · Springer eBooks · doi:10.1007/978-4-431-56077-7_3 · Cited by 2
Hypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell ResolutionPreprint
Pacholko, A. G., Schaeffer, S. M., Santisteban, M. M., Ahn, S. J., Racchumi, G., Wang, G., Park, L., Faraco, G., Anrather, J., & Iadecola, C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.14.648770 · Cited by 2
Chiral shift toward D-serine reflects intrathecal inflammation in multiple sclerosis and counteracts motor impairment in a murine modelPreprint
Usiello, A., Arisumi, K., Nuzzo, T., Gilio, L., Taniguchi, S., Russo, R., Motegi, H., di Vito, R., Hata, J., Errico, F., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.07.652561 · Cited by 2
Role of Astrocytic Serine in Learning and Memory and its Implications in Alzheimer's Disease.
Maugard, M. (2018) · theses.fr (ABES) · doi:10.70675/2a0528d8zc687z43e6za9b4zfa45cdb5b6d9 · Cited by 1

Authors: Ehmsen, J. T., Ma, T. M., Sason, H., Rosenberg, D., Ogo, T., Furuya, S., Snyder, S. H., & Wolosker, H.
Affiliations: Johns Hopkins University (US)
Technion – Israel Institute of Technology (IL)
Kyushu University (JP)
ORCID: Ehmsen, J. T.
Furuya, S.
Snyder, S. H.
Wolosker, H.
Venue: Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2013-07-24
Volume: 33
Issue: 30
Pages: 12464-12469
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.4914-12.2013
PMC: PMC3721849
OpenAlex: W2055652253
Cited by: 118
References: 27
Citations by year: 2026: 4 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 11 · 2019: 8 · 2018: 10 · 2017: 13 · 2016: 13 · 2015: 6 · 2014: 12 · 2013: 1
FWCI: 4.98
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: International Mental Health Research Organization
Legacy Heritage Fund
Israel Science Foundation
National Institutes of Health (MH18501)
Japan Society for the Promotion of Science (18300125, 22380078)
National Institute of Mental Health (R01MH018501, R37MH018501, MH-18501)
National Institute of Neurological Disorders and Stroke (NS050275)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: D-serine, 3-phosphoglycerate dehydrogenase, serine racemase, NMDA receptor, L-serine biosynthesis, astrocytes, neurons, neuron-glia interactions, transgenic mice
MeSH terms: Serine Racemase, Animals, Astrocytes, Cerebral Cortex, Female, Glucose, Male, Mice, Transgenic, Synaptic Transmission, Neurons, Promoter Regions, Genetic, Serine, Racemases and Epimerases, Green Fluorescent Proteins, Phosphoglycerate Dehydrogenase, Mice, Primary Cell Culture

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

D-Serine in Glia and Neurons Derives from 3-Phosphoglycerate Dehydrogenase

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks