The NMDA receptor ‘glycine modulatory site’ in schizophrenia: d-serine, glycine, and beyond
Open accessAbstract
Schizophrenia is a severe psychiatric illness that is characterized by reduced cortical connectivity, for which the underlying biological and genetic causes are not well understood. Although the currently approved antipsychotic drug treatments, which primarily modulate dopaminergic function, are effective at reducing positive symptoms (i.e. delusions and hallucinations), they do little to improve the disabling cognitive and negative (i.e. anhedonia) symptoms of patients with schizophrenia. This review details the recent genetic and neurobiological findings that link N-methyl-D-aspartate receptor (NMDAR) hypofunction to the etiology of schizophrenia. It also highlights potential treatment strategies that augment NMDA receptor function to treat the synaptic deficits and cognitive impairments.
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Genetic evidence points to disturbed NMDAR signaling in schizophrenia: a GWAS implicated SRR and GRIN2A as risk genes and other genes functionally up- and downstream of NMDAR activity.
“A recent genome-wide association study (GWAS) implicated serine racemase (SRR) and GRIN2A as risk genes for schizophrenia 21 as well as other genes functionally up-and downstream of NMDAR activity 21,22 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [22]
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Cites
Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) · Nature · doi:10.1038/nature13595 · Cited by 7,577 · see citing works
Krystal, J. H. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030035004 · Cited by 3,330 · see citing works
Dalmau, J., Tüzün, E., Wu, H., Masjuan, J., Rossi, J. E., Voloschin, A., Baehring, J. M., Shimazaki, H., Koide, R., King, D., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21050 · Cited by 2,492 · see citing works
Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis
Dalmau, J. O., Lancaster, E., Martínez‐Hernández, E., Rosenfeld, M. R., & Balice‐Gordon, R. J. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70253-2 · Cited by 2,428 · see citing works
De novo mutations in schizophrenia implicate synaptic networks
Fromer, M., Pocklington, A. J., Kavanagh, D. H., Williams, H. J., Dwyer, S., Gormley, P., Georgieva, L., Rees, E., Palta, P., Ruderfer, D. M., et al. (2014) · Nature · doi:10.1038/nature12929 · Cited by 1,617 · see citing works
Kynurenines in the mammalian brain: when physiology meets pathology
Schwarcz, R., Bruno, J. P., Muchowski, P. J., & Wu, H.-Q. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3257 · Cited by 1,530 · see citing works
Lifetime Prevalence of Psychotic and Bipolar I Disorders in a General Population
Perälä, J., Suvisaari, J., Saarni, S. I., Kuoppasalmi, K. I., Isometsä, E. T., Pirkola, S. P., Partonen, T., Tuulio‐Henriksson, A., Hintikka, J., Kieseppä, T., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.1.19 · Cited by 1,523 · see citing works
A polygenic burden of rare disruptive mutations in schizophrenia
Purcell, S. M., Moran, J. L., Fromer, M., Ruderfer, D., Solovieff, N., Roussos, P., O’Dushlaine, C., Chambert, K., Bergen, S. E., Kähler, A., et al. (2014) · Nature · doi:10.1038/nature12975 · Cited by 1,385 · see citing works
Allen, N. C., Bagade, S., McQueen, M. B., Ioannidis, J. P. A., Kavvoura, F. K., Khoury, M. J., Tanzi, R. E., & Bertram, L. (2008) · Nature Genetics · doi:10.1038/ng.171 · Cited by 1,054 · see citing works
Kirov, G., Pocklington, A. J., Holmans, P., Ivanov, D., Ikeda, M., Ruderfer, D., Moran, J., Chambert, K., Toncheva, D., Georgieva, L., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.154 · Cited by 844 · see citing works
Schell, M. J., Molliver, M. E., & Snyder, S. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3948 · Cited by 832 · see citing works
Wolosker, H., Blackshaw, S., & Snyder, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13409 · Cited by 811 · see citing works
Hilmas, C., Pereira, E., Alkondon, M., Rassoulpour, A., Schwarcz, R., & Albuquerque, E. X. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07463.2001 · Cited by 772 · see citing works
Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists
Papouin, T., Ladépêche, L., Ruel, J., Sacchi, S., Labasque, M., Hanini, M., Groc, L., Pollegioni, L., Mothet, J., & Oliet, S. H. R. (2012) · Cell · doi:10.1016/j.cell.2012.06.029 · Cited by 752 · see citing works
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
Belforte, J. E., Zsiros, V., Sklar, E. R., Jiang, Z., Yu, G., Li, Y., Quinlan, E. M., & Nakazawa, K. (2010) · Nature Neuroscience · doi:10.1038/nn.2447 · Cited by 752 · see citing works
Effects of Ketamine in Normal and Schizophrenic Volunteers
Lahti, A. C. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00243-3 · Cited by 674 · see citing works
Kessler, M., Terramani, T., Lynch, G., & Baudry, M. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb01881.x · Cited by 649 · see citing works
Increased cortical kynurenate content in schizophrenia
Schwarcz, R., Rassoulpour, A., Wu, H.-Q., Medoff, D., Tamminga, C. A., & Roberts, R. C. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01078-2 · Cited by 590 · see citing works
Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia.
Erhardt, S., Blennow, K., Nordin, C., Skogh, E., Lindström, L., & Engberg, G. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02242-x · Cited by 478 · see citing works
Mothet, J., Pollegioni, L., Ouanounou, G., Martineau, M., Fossier, P., & Baux, G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408483102 · Cited by 461 · see citing works
Buchanan, R. W., Javitt, D. C., Marder, S. R., Schooler, N. R., Gold, J. M., McMahon, R. P., Heresco-Levy, U., & Carpenter, W. T. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06081358 · Cited by 419 · see citing works
Modulation of N -methyl- d -aspartate receptor function by glycine transport
Bergeron, R., Meyer, T. M., Coyle, J. T., & Greene, R. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15730 · Cited by 412 · see citing works
Self-citationSteiner, J. H., Walter, M., Glanz, W., Sarnyai, Z., Bernstein, H., Vielhaber, S., Kästner, A., Skalej, M., Jordan, W., Schiltz, K., et al. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.86 · Cited by 379 · see citing works
Endogenous d ‐Serine in Rat Brain: N‐Methyl‐ d ‐Aspartate Receptor‐Related Distribution and Aging
Hashimoto, A., Nishikawa, T., Oka, T., & Takahashi, K. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03219.x · Cited by 363 · see citing works
Lugo-Huitrón, R., Blanco-Ayala, T., Ugalde-Muñiz, P., Carrillo-Mora, P., Pedraza-Chaverrí, J., Silva-Adaya, D., Maldonado, P. D., Torres, I., Pinzón, E., Ortiz-Islas, E., et al. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2011.07.002 · Cited by 346 · see citing works
Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior
Basu, A. C., Tsai, G. E., Ma, C.-L., Ehmsen, J. T., Mustafa, A. K., Han, L., Jiang, Z. I., Benneyworth, M. A., Froimowitz, M., LANGE, N. D., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.130 · Cited by 340 · see citing works
Self-citationA CSF and postmortem brain study of d-serine metabolic parameters in schizophrenia
Bendikov, I., Nadri, C., Amar, S., Panizzutti, R., DEMIRANDA, J., Wolosker, H., & Agam, G. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.10.010 · Cited by 323 · see citing works
Localization of the GLYT1 Glycine Transporter at Glutamatergic Synapses in the Rat Brain
Cubelos, B. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh147 · Cited by 291 · see citing works
Tsai, G. E., & Lin, P. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790361452 · Cited by 269 · see citing works
Paul, S. M., Doherty, J., Robichaud, A. J., Belfort, G. M., Chow, B. Y., Hammond, R., Crawford, D. C., Linsenbardt, A. J., Shu, H., Izumi, Y., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2619-13.2013 · Cited by 267 · see citing works
Hashimoto, K., Engberg, G., Shimizu, E., Nordin, C., Lindström, L. H., & Iyo, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.04.023 · Cited by 267 · see citing works
Zafra, F., Gomeza, J., Olivares, L., et al. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01125.x · Cited by 259 · see citing works
Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia
GOFF, D. C., Tsai, G. E., Manoach, D. S., & Coyle, J. T. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.8.1213 · Cited by 243 · see citing works
Self-citationSerine racemase is predominantly localized in neurons in mouse brain
Miya, K., Inoue, R., Takata, Y., Abe, M., Natsume, R., Sakimura, K., Hongou, K., Miyawaki, T., & Mori, H. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21822 · Cited by 243 · see citing works
Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia
Weickert, C. S., Fung, S. J., Catts, V. S., Schofield, P. R., Allen, K. M., Moore, L., Newell, K. A., Pellen, D., Huang, X.-F., Catts, S. V., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.137 · Cited by 234 · see citing works
Coyle, J. T., & Tsai, G. E. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1709-2 · Cited by 230 · see citing works
Self-citationAdd-on Treatment of Benzoate for Schizophrenia
Lane, H., Lin, C., Green, M. F., Hellemann, G., Huang, C., Chen, P., Tun, R., Chang, Y.-C., & Tsai, G. E. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.2159 · Cited by 229 · see citing works
Rosenberg, D., Artoul, S., Segal, A. C., Kolodney, G., Radzishevsky, I. S., Dikopoltsev, E., Foltyn, V. N., Inoue, R., Mori, H., Billard, J., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3836-12.2013 · Cited by 228 · see citing works
Jones, C. K., Byun, N. E., & Bubser, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.199 · Cited by 228 · see citing works
Balu, D. T., Li, Y., Puhl, M. D., Benneyworth, M. A., Basu, A. C., Takagi, S., Bolshakov, V. Y., & Coyle, J. T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304308110 · Cited by 217 · see citing works
Self-citationQuartermain, D., Mower, J., Rafferty, M. F., Herting, R. L., & Lanthorn, T. H. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90687-4 · Cited by 190 · see citing works
Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex
Fossat, P., Turpin, F. R., Sacchi, S., Dulong, J., Shi, T., Rivet, J., Sweedler, J. V., Pollegioni, L., Millan, M. J., Oliet, S. H. R., et al. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr130 · Cited by 185 · see citing works
Reduction of Brain Kynurenic Acid Improves Cognitive Function
Kozak, R., Campbell, B. M., Strick, C. A., Horner, W., Hoffmann, W. E., Kiss, T., Chapin, D. S., McGinnis, D. J., Abbott, A. L., Roberts, B. M., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1107-14.2014 · Cited by 182 · see citing works
Storage and Uptake of d-Serine into Astrocytic Synaptic-Like Vesicles Specify Gliotransmission
Martineau, M., Shi, T., Puyal, J., Knolhoff, A. M., Dulong, J., Gasnier, B., Klingauf, J., Sweedler, J. V., Jahn, R., & Mothet, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3497-12.2013 · Cited by 172 · see citing works
The neurobiology of D-amino acid oxidase and its involvement in schizophrenia
Verrall, L., Burnet, P. W. J., Betts, J. F., & Harrison, P. J. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.99 · Cited by 171 · see citing works
Benneyworth, M. A., Li, Y., Basu, A. C., Bolshakov, V. Y., & Coyle, J. T. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9808-4 · Cited by 153 · see citing works
Self-citationAlbuquerque, E. X., & Schwarcz, R. M. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.12.014 · Cited by 150 · see citing works
Glycine transporters: essential regulators of synaptic transmission
Betz, H., Gomeza, J., Armsen, W., Scholze, P., & Eulenburg, V. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340055 · Cited by 148 · see citing works
Yang, J. H., Wada, A., Yoshida, K., Miyoshi, Y., Sayano, T., Esaki, K., Kinoshita, M. O., Tomonaga, S., Azuma, N., Watanabe, M., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.187443 · Cited by 147 · see citing works
d-Serine and Serine Racemase are Localized to Neurons in the Adult Mouse and Human Forebrain
Balu, D. T., Takagi, S., Puhl, M. D., Benneyworth, M. A., & Coyle, J. T. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0027-z · Cited by 126 · see citing works
Self-citationKarlsgodt, K. H., Robleto, K., Trantham‐Davidson, H., Jairl, C., Cannon, T. D., Lavı́n, A., & Jentsch, J. D. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.012 · Cited by 119 · see citing works
D-serine in glia and neurons derives from 3-phosphoglycerate dehydrogenase
Ehmsen, J. T., Ma, T. M., Sason, H., Rosenberg, D., Ogo, T., Furuya, S., Snyder, S. H., & Wolosker, H. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4914-12.2013 · Cited by 118 · see citing works
Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology
DeVito, L. M., Balu, D. T., Kanter, B. R., Lykken, C., Basu, A. C., COYLE, J. T., & Eichenbaum, H. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00656.x · Cited by 114 · see citing works
Self-citationA Genetic Variant of the Serine Racemase Gene Is Associated with Schizophrenia
Morita, Y., Ujike, H., Tanaka, Y., Otani, K., Kishimoto, M., Morio, A., Kotaka, T., Okahisa, Y., Matsushita, M., Morikawa, A., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.025 · Cited by 112 · see citing works
Understanding structural brain changes in schizophrenia
DeLisi, L. E., Szulc, K. U., Bertisch, H. C., Majcher, M., & Brown, K. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.1/ldelisi · Cited by 106 · see citing works
Carlson, G. C., Talbot, K., Halene, T. B., Gandal, M. J., Kazi, H. A., Schlosser, L., Phung, Q. H., Gur, R. E., Arnold, S. E., & Siegel, S. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109625108 · Cited by 103 · see citing works
Li, Y., Sacchi, S., Pollegioni, L., Basu, A. C., Coyle, J. T., & Bolshakov, V. Y. (2013) · Nature Communications · doi:10.1038/ncomms2779 · Cited by 82 · see citing works
Self-citationCLC-3 Channels Modulate Excitatory Synaptic Transmission in Hippocampal Neurons
Wang, X. Q., Deriy, L. V., Foss, S., Huang, P., Lamb, F. S., Kaetzel, M. A., Bindokas, V. P., Marks, J. D., & Nelson, D. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.035 · Cited by 79 · see citing works
CASK Regulates SAP97 Conformation and Its Interactions with AMPA and NMDA Receptors
Lin, E. I., Jeyifous, O., & Green, W. N. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0816-13.2013 · Cited by 58 · see citing works
Genetic loss of D‐amino acid oxidase activity reverses schizophrenia‐like phenotypes in mice
Labrie, V., Wang, W., Barger, S. W., Baker, G. B., & Roder, J. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00529.x · Cited by 55 · see citing works
Polymorphism in the 5′-promoter region of serine racemase gene in schizophrenia
Goltsov, A. Y., Loseva, J. G., Андреева, Т. В., Grigorenko, A. P., Abramova, L. I., Каледа, В. Г., Александровна, О. В., Moliaka, Y. K., & Rogaev, E. I. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001801 · Cited by 50 · see citing works
Guzman, R. E., Alekov, A. K., Filippov, M., Hegermann, J., & Fahlke, C. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00143 · Cited by 38 · see citing works
Metabotropic Glutamate Receptors for New Treatments in Schizophrenia
Herman, E. J., Bubser, M., Conn, P. J., & Jones, C. K. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25758-2_11 · Cited by 35 · see citing works
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Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686 · see citing works
Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis
Hardingham, G. E., & Do, K. Q. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.19 · Cited by 304 · see citing works
Kantrowitz, J. T., Epstein, M. L., Lee, M., Lehrfeld, N., Nolan, K. A., Shope, C., Petkova, E., Silipo, G., & Javitt, D. C. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2017.02.027 · Cited by 123 · see citing works
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Ferreira, J. S., Papouin, T., Ladépêche, L., Yao, A., Langlais, V. C., Bouchet, D., Dulong, J., Mothet, J.-P., Sacchi, S., Pollegioni, L., et al. (2017) · eLife · doi:10.7554/elife.25492 · Cited by 110 · see citing works
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Hunt, M. J., Olszewski, M., Piasecka, J., Whittington, M. A., & Kasicki, S. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4073-0 · Cited by 20 · see citing works
- Authors
- Balu, D. T., & Coyle, J. T.
- Affiliations
- Harvard University (US)
- Corresponding author
- Coyle, Joseph T
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 20
- Pages
- 109-115
- ISSN
- 1471-4892 (ISSN-L)
- PMC
- PMC4805108
- OpenAlex
- W1996473902
- Cited by
- 208
- References
- 63
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 11 · 2023: 13 · 2022: 5 · 2021: 23 · 2020: 19 · 2019: 13 · 2018: 24 · 2017: 39 · 2016: 21 · 2015: 17
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50MH060450, R01MH051290, R01MH05190, P50MH0G0450, K99MH099252)
- National Institute on Drug Abuse (R21DA035427)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- schizophrenia, NMDA receptor, D-serine, glycine, NMDA receptor hypofunction, cortical connectivity, cognitive impairment, negative symptoms, synaptic deficits, genetic etiology
- MeSH terms
- Animals, Cognition Disorders, Dopamine, Glycine, Humans, Schizophrenia, Serine, Synapses, Antipsychotic Agents, Receptors, N-Methyl-D-Aspartate
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