Essential Function of Oncostatin M in Nociceptive Neurons of Dorsal Root Ganglia
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Oncostatin M (OSM) is a member of the interleukin-6 family of cytokines, and we have reported previously that the murine OSM receptor β subunit (OSMR) was expressed in some neurons in the adult trigeminal and dorsal root ganglia (DRGs) and in the perineonatal hypoglossal nucleus. In the present study, we investigated the development of OSMR-positive neurons of DRGs in OSM-deficient mice.In situ hybridization revealed that OSMR-positive neurons in DRGs began to appear at postnatal day 0 (P0) and reached the adult level at P14. In the DRGs of the OSM-deficient mice, vanilloid receptor 1 (VR1)- and P2X3-positive small-sized neurons were significantly decreased. In addition, OSMR-positive neurons decreased, resulting in the reduced number of VR1/P2X3/OSMR-triple positive neurons. OSM-deficient mice displayed significantly reduced noxious responses in models of acute thermal, mechanical, chemical, and visceral pain. Thus, OSM plays an essential role in the development of a subtype of nociceptive neurons in the DRGs.
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Self-citationExpression pattern of leucine-rich repeat neuronal protein 4 in adult mouse dorsal root ganglia
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Self-citationTim2 is expressed in mouse fetal hepatocytes and regulates their differentiation†
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Comparative studies of oncostatin M expression in the tissues of adult rodents
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Oncostatin M promotes chronic pain through direct regulation on nociceptors in rats
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- Authors
- Morikawa, Y., Tamura, S., Minehata, K.-I., Donovan, P. J., Miyajima, A., & Senba, E.
- Affiliations
- Wakayama Medical University (JP)
- The University of Tokyo (JP)
- Thomas Jefferson University (US)
- Japan Science and Technology Agency (JP)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-02-25
- Volume
- 24
- Issue
- 8
- Pages
- 1941-1947
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6730413
- OpenAlex
- W2135584174
- Cited by
- 80
- References
- 45
- Citations by year
- 2026: 3 · 2025: 3 · 2023: 1 · 2022: 3 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (15500264)
- Wakayama Medical University
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- oncostatin M, dorsal root ganglia, nociceptors, vanilloid receptor 1, P2X3 receptor, neuronal development, postnatal development, acute pain, visceral pain, thermal pain, mechanical pain, chemical pain, trigeminal ganglion, interleukin-6 family cytokines
- MeSH terms
- Animals, Antigens, Differentiation, Behavior, Animal, Cell Count, Fluorescent Antibody Technique, Ganglia, Spinal, Male, Mice, Inbred C57BL, Neurons, Pain, Pain Measurement, Peptides, Receptors, Drug, RNA, Messenger, In Situ Hybridization, Receptors, Purinergic P2, Receptors, Cytokine, Mice, Knockout, Gene Targeting, Gene Expression Regulation, Developmental, Cell Size, Mice, Receptors, Oncostatin M, Oncostatin M, Receptors, Purinergic P2X3
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