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Essential Function of Oncostatin M in Nociceptive Neurons of Dorsal Root Ganglia

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Morikawa, Yoshihiro, Tamura, Shinobu, Minehata, Ken-ichi, Donovan, Peter J., Miyajima, Atsushi, Senba, Emiko·2004·The Journal of Neuroscience

Abstract

Oncostatin M (OSM) is a member of the interleukin-6 family of cytokines, and we have reported previously that the murine OSM receptor β subunit (OSMR) was expressed in some neurons in the adult trigeminal and dorsal root ganglia (DRGs) and in the perineonatal hypoglossal nucleus. In the present study, we investigated the development of OSMR-positive neurons of DRGs in OSM-deficient mice.In situ hybridization revealed that OSMR-positive neurons in DRGs began to appear at postnatal day 0 (P0) and reached the adult level at P14. In the DRGs of the OSM-deficient mice, vanilloid receptor 1 (VR1)- and P2X3-positive small-sized neurons were significantly decreased. In addition, OSMR-positive neurons decreased, resulting in the reduced number of VR1/P2X3/OSMR-triple positive neurons. OSM-deficient mice displayed significantly reduced noxious responses in models of acute thermal, mechanical, chemical, and visceral pain. Thus, OSM plays an essential role in the development of a subtype of nociceptive neurons in the DRGs.

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Crossref · 10.1523/jneurosci.4975-03.2004

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Authors
Morikawa, Y., Tamura, S., Minehata, K.-I., Donovan, P. J., Miyajima, A., & Senba, E.
Affiliations
  • Wakayama Medical University (JP)
  • The University of Tokyo (JP)
  • Thomas Jefferson University (US)
  • Japan Science and Technology Agency (JP)
Venue
The Journal of Neuroscience
Published
2004-02-25
Volume
24
Issue
8
Pages
1941-1947
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2135584174
Cited by
80
References
45
Citations by year
2026: 3 · 2025: 3 · 2023: 1 · 2022: 3 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 2
FWCI
2.68
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology (15500264)
  • Wakayama Medical University
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
oncostatin M, dorsal root ganglia, nociceptors, vanilloid receptor 1, P2X3 receptor, neuronal development, postnatal development, acute pain, visceral pain, thermal pain, mechanical pain, chemical pain, trigeminal ganglion, interleukin-6 family cytokines
MeSH terms
Animals, Antigens, Differentiation, Behavior, Animal, Cell Count, Fluorescent Antibody Technique, Ganglia, Spinal, Male, Mice, Inbred C57BL, Neurons, Pain, Pain Measurement, Peptides, Receptors, Drug, RNA, Messenger, In Situ Hybridization, Receptors, Purinergic P2, Receptors, Cytokine, Mice, Knockout, Gene Targeting, Gene Expression Regulation, Developmental, Cell Size, Mice, Receptors, Oncostatin M, Oncostatin M, Receptors, Purinergic P2X3

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