Cited by 153Hematopoietic Stem Cell TransplantationLiver physiology and pathologyCytokine Signaling Pathways and Interactions

Role of Oncostatin M in hematopoiesis and liver development

Miyajima, Atsushi, Kinoshita, Taisei, Tanaka, Minoru, Kamiya, Akihide, Mukouyama, Yousuke, Hara, Takahiko·2000·Cytokine & Growth Factor Reviews

Abstract

Definitive hematopoietic stem cells (HSCs) first appear in the aorta/gonad/mesonephros (AGM) region and migrate to the fetal liver where they massively produce hematopoietic cells before establishing hematopoiesis in the bone marrow at a perinatal stage. In the AGM region, Oncostatin M (OSM) enhances the development of both hematopoietic and endothelial cells by possibly stimulating their common precursors, so-called hemangioblasts. During development of HSCs in the AGM region, the liver primodium is formed at the foregut and accepts HSCs. While fetal hepatic cells function as hematopoietic microenvironment for expansion of hematopoietic cells during mid to late gestation, they do not possess most of the metabolic functions of adult liver. Along with the expansion of hematopoietic cells in fetal liver, OSM is produced by hematopoietic cells and induces differentiation of fetal hepatic cells, conferring various metabolic activities of adult liver. Matured hepatic cells then lose the ability to support hematopoiesis. Thus, OSM appears to coordinate the development of liver and hematopoiesis in the fetus.

Integrity signals

Registry

Crossref · 10.1016/s1359-6101(00)00003-4

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • OSM, LIF, and CT-1 have been implicated in liver functions such as development, hepatocyte differentiation, or inflammation, but have not yet been examined in liver regeneration.

    “These cytokines have been implicated in liver functions such as development, hepatocyte differentiation, or inflammation (31)(32)(33), but have yet to be examined in liver regeneration.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Miyajima, A., Kinoshita, T., Tanaka, M., Kamiya, A., Mukouyama, Y., & Hara, T.
Affiliations
  • Kanagawa Academy of Science and Technology (JP)
  • The University of Tokyo (JP)
Corresponding author
Miyajima, Atsushi
Venue
Cytokine & Growth Factor Reviews
Publisher
Elsevier BV
Published
2000-09
Volume
11
Issue
3
Pages
177-183
ISSN
1359-6101 (ISSN-L)
OpenAlex
W2073807783
Cited by
153
References
60
Citations by year
2026: 3 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 4
FWCI
1.52
Type
journal article
Language
en
Open access
closed
Locations
  • Cytokine & Growth Factor Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
Core Research for Evolutional Science and Technology
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords
oncostatin M, hematopoiesis, liver development, hematopoietic stem cells, aorta-gonad-mesonephros, fetal liver, hemangioblasts, hematopoietic microenvironment, cytokine signaling
MeSH terms
Animals, Aorta, Gonads, Growth Inhibitors, Hematopoiesis, Humans, Liver, Mesonephros, Peptides, Receptors, Cytokine, Receptors, Oncostatin M, Oncostatin M

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review