The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Amyloid-β 1–42 Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1
Open accessAbstract
GLT-1, the major glutamate transporter in the adult brain, is abundantly expressed in astrocytic processes enveloping synapses. By limiting glutamate escape into the surrounding neuropil, GLT-1 preserves the spatial specificity of synaptic signaling. Here we show that the amyloid-β peptide Aβ 1–42 markedly prolongs the extracellular lifetime of synaptically released glutamate by reducing GLT-1 surface expression in mouse astrocytes and that this effect is prevented by the vitamin E derivative Trolox. These findings indicate that astrocytic glutamate transporter dysfunction may play an important role in the pathogenesis of Alzheimer's disease and suggest possible mechanisms by which several current treatment strategies could protect against the disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“while Aβ42 was shown to impair the function of the excitatory amino acid transporter (GLT-1) and the glutamate/aspartate transporter (GLAST) in hippocampal astrocytes [12].”
From Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease (2022) · cites this paper as [12]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Statistical Principles in Experimental Design
Green, P. E., Winer, B. J., Brown, D. R., & Michels, K. M. (1992) · Journal of Marketing Research · doi:10.2307/3172747 · Cited by 4,333
Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1
Tanaka, K., Watase, K., Manabe, T., Yamada, K., Watanabe, M., Takahashi, K., Iwama, H., Nishikawa, T., Ichihara, N., Kikuchi, T., et al. (1997) · Science · doi:10.1126/science.276.5319.1699 · Cited by 1,755
Primary structure and functional characterization of a high-affinity glutamate transporter
Kanai, Y., & Hediger, M. A. (1992) · Nature · doi:10.1038/360467a0 · Cited by 1,337
In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis
Stine, W. B., Dahlgren, K. N., Krafft, G. A., & LaDu, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210207200 · Cited by 1,015
Chaudhry, F. A., Lehre, K. P., Campagne, M. V. L., Ottersen, O. P., Danbolt, N. C., & Storm‐Mathisen, J. (1995) · Neuron · doi:10.1016/0896-6273(95)90158-2 · Cited by 838
Felipo, V., & Butterworth, R. F. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00019-9 · Cited by 626
Neuronal Regulation of Glutamate Transporter Subtype Expression in Astrocytes
Swanson, R. A., Liu, J., Miller, J. W., Rothstein, J. D., Farrell, K., Stein-Behrens, B., & Longuemare, M. C. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-03-00932.1997 · Cited by 500
Brain Glutamate Transporter Proteins Form Homomultimers
Haugeto, Ø., Ullensvang, K., Levy, L. M., Chaudhry, F. A., Honoré, T., Nielsen, M., Lehre, K. P., & Danbolt, N. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27715 · Cited by 497
Deficient glutamate tranport is associated with neurodegeneration in Alzheimer's disease
Masliah, E., Hansen, L., Alford, M., Deteresa, R., & Mallory, M. (1996) · Annals of Neurology · doi:10.1002/ana.410400512 · Cited by 476
Transporters Buffer Synaptically Released Glutamate on a Submillisecond Time Scale
Diamond, J. S., & Jahr, C. E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04672.1997 · Cited by 476
Self-citation
Cited by
Sorted by citations
Items 101–186 of 186
McCarty, M. F., DiNicolantonio, J. J., & Lerner, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042140 · Cited by 27
van den Berg, M., Adhikari, M. H., Verschuuren, M., Pintelon, I., Vasilkovska, T., Audekerke, J. V., Missault, S., Heymans, L., Ponsaerts, P., Vos, W. H. D., et al. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01089-2 · Cited by 26
Pathological Interplay between Inflammation and Mitochondria Aggravates Glutamate Toxicity
Vaglio-Garro, A., Kozlov, A. V., Smirnova, Y. D., & Weidinger, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042276 · Cited by 26
Potential Astrocytic Receptors and Transporters in the Pathogenesis of Alzheimer’s Disease
Zhang, X., Lao, K., Qiu, Z., Rahman, M. S., Zhang, Y., & Gou, X. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181084 · Cited by 24
Goldberg, N. R. S., Marsh, S. E., Ochaba, J., Shelley, B., Davtyan, H., Thompson, L. M., Steffan, J. S., Svendsen, C. N., & Blurton-Jones, M. M. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0362 · Cited by 23
Gao, J., Liu, L., Liu, C., Fan, S., Liu, L., Liu, S., Xian, X., & Li, W. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.580772 · Cited by 21
Rǎdulescu, A., Todd, G. C., Williams, C., Bennink, B., Lemus, A. A., Chesbro, H. E., Bourgeois, J. R., Kopec, A. M., Zuloaga, D. G., & Scimemi, A. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009845 · Cited by 24
Self-citationFuchsberger, T., Yuste, R., Martínez‐Bellver, S., Blanco-Gandia, M.-C., Torres-Cuevas, I., Blasco‐Serra, A., Arango, R., Miñarro, J., Rodríguez‐Arias, M., Teruel‐Martí, V., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190274 · Cited by 21
Synaptic and Sub-Synaptic Localization of Amyloid-β Protein Precursor in the Rat Hippocampus
Rodrigues, D. I., Gutierres, J. M., Pliássova, A., Oliveira, C. R., Cunha, R. A., & Agostinho, P. M. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132030 · Cited by 18
Entering a new era of quantifying glutamate clearance in health and disease
Brymer, K. J., Barnes, J. R., & Parsons, M. P. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24810 · Cited by 17
Bao, Y., Yang, X., Fu, Y., Zhengyan, L., Gong, R., & Lü, W. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00260-3 · Cited by 18
Brymer, K. J., Hurley, E. P., Barron, J. C., Mukherjee, B., Barnes, J. R., Nafar, F., & Parsons, M. P. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01524-x · Cited by 18
da Silva, J. S., Nonose, Y., Rohden, F., Ferreira, P. C. L., Fontella, F. U., da Rocha, A. S., Brochier, A. W., Apel, R. V., de Lima, T. M., Seminotti, B., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02064-4 · Cited by 17
Modifiable risk factors of dementia linked to excitation-inhibition imbalance
Hafizi, S., & Rajji, T. K. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101804 · Cited by 16
Chen, T., Tanaka, M., Wang, Y., Sha, S., Furuya, K., Chen, L., & Sokabe, M. (2017) · Glia · doi:10.1002/glia.23175 · Cited by 15
Folorunso, O. O., Harvey, T. L., Brown, S. E., Chelini, G., Berretta, S., & Balu, D. T. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136958 · Cited by 15
Pérez-Jiménez, E., Viana, R., Muñoz‐Ballester, C., Vendrell‐Tornero, C., Moll‐Diaz, R., García-Gimeno, M. A., & Sanz, P. (2020) · Glia · doi:10.1002/glia.23956 · Cited by 13
Characterization of reduced astrocyte creatine kinase levels in Alzheimer's disease
Zheng, T., Kotol, D., Sjöberg, R., Mitsios, N., Uhlén, M., Zhong, W., Edfors, F., & Mulder, J. (2024) · Glia · doi:10.1002/glia.24569 · Cited by 14
Li, L., Li, W., Jiang, W., & Xu, R. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01827-5 · Cited by 13
Manisha, C., Ayyamperumal, S., Selvaraj, J., Nanjan, C. M. J., Joghee, N. M., Clement, J. P., & Justin, A. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109794 · Cited by 13
Potential Mechanism of Cellular Uptake of the Excitotoxin Quinolinic Acid in Primary Human Neurons
Braidy, N., Alicajic, H., Pow, D. V., Smith, J. R., Jugder, B., Brew, B. J., Nicolazzo, J. A., & Guillemin, G. J. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02046-6 · Cited by 12
Turečková, J., Kamenická, M., Koleničová, D., Filipi, T., Heřmanová, Z., Kriška, J., Mészárošová, L., Pukajova, B., Valihrach, L., Androvic, P., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.783120 · Cited by 12
Li, J., Liu, Y., Yin, C., Zeng, Y., & Mei, Y. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102468 · Cited by 13
Liu, H., Tan, A. Y. S., Mehrabi, N. F., Turner, C. P., Curtis, M. A., Faull, R. L. M., Dragunow, M., Singh‐Bains, M. K., & Smith, A. M. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106749 · Cited by 11
Loss of maturity and homeostatic functions in Tuberous Sclerosis Complex-derived astrocytes
Luinenburg, M. J., Scheper, M., Sørensen, F. N. F., Anink, J. J., Hecke, W. V., Korshunova, I., Jansen, F. E., Riney, K., van Eijsden, P., Gosselaar, P. H., et al. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1284394 · Cited by 11
Kozin, S. V., Ivashchenko, L. I., Kravtsov, A. A., Vasilyeva, L. V., Vasiliev, A. M., Николаевич, Б. Н., Dorohova, A. A., Lyasota, O. M., Беспалов, А. В., & Dzhimak, S. S. (2023) · BIOPHYSICS · doi:10.1134/s0006350923010098 · Cited by 10
Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice
Wilcox, J. M., Consoli, D. C., Tienda, A. A., Dixit, S., Buchanan, R. A., May, J. M., Nobis, W. P., & Harrison, F. E. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105486 · Cited by 10
Differential expression of glutamate transporters in cerebral cortex of paraoxon-treated rats
Zare, Z., Tehrani, M., Rafiei, A., Valadan, R., & Mohammadi, M. (2017) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2017.06.001 · Cited by 9
The Quest for Neurodegenerative Disease Treatment—Focusing on Alzheimer’s Disease Personalised Diets
Palimariciuc, M., Balmuș, I.-M., Gireadă, B., Ciobica, A. S., Chiriță, R., Iordache, A.-C., Apostu, M., & Dobrin, R. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45020098 · Cited by 9
Al-Jaf, S., Soliman, A. Y., EL‐Yazbi, A. F., & Abd‐Elrahman, K. S. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00614 · Cited by 8
Liu, L.-Z., Fan, S., Gao, J., Li, W., & Xian, X. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110683 · Cited by 9
A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity
Bonifazi, G., Luchena, C., Gaminde‐Blasco, A., Ortiz-Sanz, C., Capetillo‐Zarate, E., Matute, C., Alberdi, E. M., & Pittà, M. D. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106473 · Cited by 9
Li, G., Li, F., Tang, Y., Guo, S., Yao, Y., Yuan, F., Zhang, B., Jiang, Y. Y., Wang, J., Wu, D., et al. (2025) · MedComm · doi:10.1002/mco2.70556 · Cited by 6
Wu, J., Tang, J., Huang, D., Wang, Y., Zhou, E., Ru, Q., Xu, G., Chen, L., & Wu, Y. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1482947 · Cited by 7
The Role of Astrocytes in Neurotransmitter Uptake and Brain Metabolism
Scimemi, A. (2019) · Springer series in computational neuroscience · doi:10.1007/978-3-030-00817-8_12 · Cited by 7
Self-citationRao, R., Verma, H., Gangwar, P., Yadav, A., Yadav, B., Patel, A., Kaur, S., Dhiman, M., & Mantha, A. K. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05435-x · Cited by 5
Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy
Schneider, Y., Gauer, C., Andert, M., Hoffmann, A., Riemenschneider, M. J., Krebs, W., Chalmers, N., Lötzsch, C., Naumann, U. J., Xiang, W., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01699-3 · Cited by 7
Perrin, F., Anderson, L. C., Mitchell, S. P. C., Sinha, P., Turchyna, Y., Maesako, M., Houser, M. C., Zhang, C. M., Wagner, S. L., Tanzi, R. E., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01876-y · Cited by 6
Reactive Astrocytes with Reduced Function of Glutamate Transporters in the App NL-G-F Knock-in Mice
Srivastava, I., Goikolea, J., Kaya, T. A., Latorre‐Leal, M., Eroli, F., Iglesias, M. P., Álvarez-Jiménez, L., Arroyo‐García, L. E., Shimozawa, M., Nilsson, P., et al. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00714 · Cited by 8
Min-Kaung-Wint-Mon, & Mitsushima, D. (2025) · Journal of dementia and Alzheimer's disease · doi:10.3390/jdad2030025 · Cited by 5
Yan, J., Yang, X., Li, G., Ramírez, O. A., Hagenston, A. M., Chen, Z.-Y., & Bading, H. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03143-5 · Cited by 6
Curing the brain: in search for new astrocyte-specific therapies
Verkhratsky, A., Lee, C. J., Chun, H., Göritz, C., Harkany, T., Lee, J., Lee, S., Lindskog, M., Koh, W., Mulder, J., et al. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01712-4 · Cited by 8
Glutamate Uptake by Astrocytic Transporters
Mergenthaler, K., Oschmann, F., & Obermeyer, K. (2019) · Springer series in computational neuroscience · doi:10.1007/978-3-030-00817-8_13 · Cited by 3
Effects of virgin olive oil phenolic compounds on health: solid evidence or just another fiasco?
Castellano, J. M., & Perona, J. S. (2021) · Grasas y Aceites · doi:10.3989/gya.0217201 · Cited by 4
Liu, L.-R., Li, L., Lu, L.-L., Fan, S., Liu, L.-Z., He, R.-B., Li, H., Xian, X.-H., & Li, W. (2025) · Alzheimer's Research & Therapy · doi:10.1186/s13195-025-01900-w · Cited by 3
Glutamate Transporter 1 as a Novel Negative Regulator of Amyloid β
Sinha, P., Turchyna, Y., Mitchell, S., Sadek, M., Armagan, G., Perrin, F., Maesako, M., & Berezovska, O. (2024) · Cells · doi:10.3390/cells13191600 · Cited by 3
The adhesion GPCR ADGRV1 controls glutamate homeostasis in hippocampal astrocytes supporting neurons
Güler, B. E., Zorin, M., Linnert, J., Nagel‐Wolfrum, K., & Wolfrum, U. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02282-2 · Cited by 8
Is EAAT2 a potential therapeutic intervention target for Alzheimer’s disease?
Kwakowsky, A., Wood, O. G., & Yeung, J. Y. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.363834 · Cited by 3
Glutamate Transporters in Health and Disease
Reeb, K. L., Gill, S. K., Temmermand, R., & Fontana, A. C. K. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1005544 · Cited by 2
Washiyama, M. (2022) · THE JOURNAL OF ISLAND STUDIES · doi:10.5995/jis.23.2.123 · Cited by 2
APP /Aβ Signaling Orchestrates Reactive Astrocyte Networks in Alzheimer's Disease
Jáuregui, G. V., Coomes, S., Emmett, E., Thatcher, A., Oyelakin, N., Čarná, M., Zelinková, J., Novotný, J., Polakova, N., Kuruvilla, T., et al. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70526 · Cited by 1
Inflammation and the Pathophysiology of Astrocytes in Neurodegenerative Diseases
Meares, G. P., & Benveniste, E. N. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1071-7_4 · Cited by 1
Role of Reactive Astrocytes in Alzheimer’s Disease
Sarkar, S., Guha, S., & Biswas, S. C. (2022) · Springer eBooks · doi:10.1007/978-981-16-8313-8_9 · Cited by 1
Fatima, A., & Daou, A. (2024) · Journal of Student Research · doi:10.47611/jsrhs.v13i1.6191 · Cited by 1
Drugs to Alter Extracellular Concentration of Glutamate: Modulators of Glutamate Uptake Systems
Fontana, A. C. K. (2017) · Neuromethods · doi:10.1007/978-1-4939-7228-9_7 · Cited by 1
An increased excitation and inhibition onto CA1 pyramidal cells sets the path to Alzheimer’s diseasePreprint
Wehrle, P. H., Rathwell, T. J., Petroccione, M. A., Caiazza, E. D., Manning, A. K., dos Reis, L. F., Todd, G. C., Affinnih, N., Ahmad, S., Mehdi, H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.27.656417 · Cited by 1
Self-citationMagcalas, C. M. (2015) · UNM’s Digital Repository (University of New Mexico)
Dong, Y., Lin, H., Rattelle, A., Panzer, J. A., & Lynch, D. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65836-1 · Cited by 1
Wolf, M. E. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733232114.793545840
Brymer, K. J., Hurley, E. P., Barron, J. C., Mukherjee, B., Barnes, J. R., Nafar, F., & Parsons, M. P. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.21.489062
Glial Cell Biology and Their Multifaceted Functions in Alzheimer's Disease
Laadraoui, J., Kabdy, H., Azraida, H., Aimrane, A., & Smimih, K. (2023) · Advances in bioinformatics and biomedical engineering book series · doi:10.4018/978-1-6684-9675-6.ch015
Kozin, S. V., Ivashchenko, L. I., Kravtsov, A. A., Vasilyeva, L. V., Vasiliev, A. M., Николаевич, Б. Н., Dorohova, A. A., Lyasota, O. M., & Беспалов, А. В. (2023) · Биофизика · doi:10.31857/s0006302923010039
Perturbations to Stimulus-Dependent Gene Activity Patterns in Neurodegenerative Disorders
Madabhushi, R., & Tsai, L. (2024) · Springer eBooks · doi:10.1007/978-3-031-68550-7_15
Succinate Dehydrogenase in Mitochondrial Disorders
Tripathi, S., Sharma, Y., & Kumar, D. (2025) · Springer eBooks · doi:10.1007/978-981-96-6831-1_5
Regulated cell death and inflammaging in neurodegenerative disorders
Liu, H., Wen, S., Gao, X., Wu, C., Lai, B., Zhu, J., & Kong, E. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-32852-7.00009-7
Bao, Y., Yang, X., Fu, Y., Zhengyan, L., Gong, R., & Lu, W. (2021) · Figshare · doi:10.6084/m9.figshare.16590459
Schneider, Y., Gauer, C., Andert, M., Hoffmann, A., Riemenschneider, M. J., Krebs, W., Chalmers, N., Lötzsch, C., Naumann, U. J., Xiang, W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26658460
Brymer, K. J., Hurley, E. P., Barron, J. C., Mukherjee, B., Barnes, J. R., Nafar, F., & Parsons, M. P. (2024) · Figshare · doi:10.6084/m9.figshare.26568469
van den Berg, M., Adhikari, M. H., Verschuuren, M., Pintelon, I., Vasilkovska, T., Audekerke, J. V., Missault, S., Heymans, L., Ponsaerts, P., Vos, W. H. D., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21311016
Schneider, Y., Gauer, C., Andert, M., Hoffmann, A., Riemenschneider, M. J., Krebs, W., Chalmers, N., Lötzsch, C., Naumann, U. J., Xiang, W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26658454
Schneider, Y., Gauer, C., Andert, M., Hoffmann, A., Riemenschneider, M. J., Krebs, W., Chalmers, N., Lötzsch, C., Naumann, U. J., Xiang, W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26658463
Schneider, Y., Gauer, C., Andert, M., Hoffmann, A., Riemenschneider, M. J., Krebs, W., Chalmers, N., Lötzsch, C., Naumann, U. J., Xiang, W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24934474
Schneider, Y., Gauer, C., Andert, M., Hoffmann, A., Riemenschneider, M. J., Krebs, W., Chalmers, N., Lötzsch, C., Naumann, U. J., Xiang, W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26658457
Schneider, Y., Gauer, C., Andert, M., Hoffmann, A., Riemenschneider, M. J., Krebs, W., Chalmers, N., Lötzsch, C., Naumann, U. J., Xiang, W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24934579
Schneider, Y., Gauer, C., Andert, M., Hoffmann, A., Riemenschneider, M. J., Krebs, W., Chalmers, N., Lötzsch, C., Naumann, U. J., Xiang, W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26658448
Schneider, Y., Gauer, C., Andert, M., Hoffmann, A., Riemenschneider, M. J., Krebs, W., Chalmers, N., Lötzsch, C., Naumann, U. J., Xiang, W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26658451
Microbiota and Alzheimer's disease: Toward new clinical approaches
Đokić, J., & Dinić, M. (2025) · Medicinski podmladak · doi:10.5937/mp76-60520 · Cited by 1
Subramanian, J. (2026) · The Neuroscientist · doi:10.1177/10738584251414384 · Cited by 1
Vautheny, A. (2019) · theses.fr (ABES) · doi:10.70675/1812d71aze8d9z48d6z87d1z5a23a4e81953
Li, Y., & Yang, X. (2026) · Nonlinear Dynamics · doi:10.1007/s11071-026-12358-2
Hétérogénéité de la réactivité astrocytaire dans la maladie d'Alzheimer
Guillemaud, O. (2020) · theses.fr (ABES) · doi:10.70675/038d98c5z55ccz4754z9af9z417e3826d282
Perisynaptic Astrocytic Processes as Communication Hubs and Early Sites of Dysfunction
Puletti, F., Tugulu, I., & Hong, S. Y. (2026) · The Neuroscientist · doi:10.1177/10738584261445356
Salunkhe, J., & Ugale, V. G. (2026) · Drug Development Research · doi:10.1002/ddr.70367
Sun, J., Gao, G., Wang, S., Li, S., Tang, J., Liu, H., & Tang, T.-S. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02776-4
Metadata
- Authors
- Scimemi, A., Meabon, J. S., Woltjer, R. L., Sullivan, J. M., Diamond, J. S., & Cook, D. G.
- Affiliations
- National Institutes of Health (US)
- VA Puget Sound Health Care System (US)
- Oregon Health & Science University (US)
- University of Washington (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-03-20
- Volume
- 33
- Issue
- 12
- Pages
- 5312-5318
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3866500
- OpenAlex
- W1979889191
- Cited by
- 185
- References
- 28
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 23 · 2023: 9 · 2022: 22 · 2021: 15 · 2020: 18 · 2019: 12 · 2018: 11 · 2017: 19 · 2016: 7 · 2015: 13 · 2014: 11 · 2013: 1
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (T32AG000258)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK017047)
- National Institute of Neurological Disorders and Stroke (R01NS055804, ZIANS002986, Z01NS002986)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- amyloid-beta 42, GLT-1, glutamate transporters, astrocytes, glutamate clearance, Alzheimer's disease, Trolox, vitamin E, extracellular glutamate
- MeSH terms
- Alzheimer Disease, Animals, Antioxidants, Astrocytes, Chromans, Drug Interactions, Extracellular Space, Female, Hippocampus, Male, Mice, Inbred C57BL, Models, Neurological, Neurons, Organ Culture Techniques, Peptide Fragments, Synapses, Amyloid beta-Peptides, Glutamic Acid, Excitatory Amino Acid Transporter 2, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review