The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Amyloid-β 1–42 Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1
Open accessAbstract
GLT-1, the major glutamate transporter in the adult brain, is abundantly expressed in astrocytic processes enveloping synapses. By limiting glutamate escape into the surrounding neuropil, GLT-1 preserves the spatial specificity of synaptic signaling. Here we show that the amyloid-β peptide Aβ 1–42 markedly prolongs the extracellular lifetime of synaptically released glutamate by reducing GLT-1 surface expression in mouse astrocytes and that this effect is prevented by the vitamin E derivative Trolox. These findings indicate that astrocytic glutamate transporter dysfunction may play an important role in the pathogenesis of Alzheimer's disease and suggest possible mechanisms by which several current treatment strategies could protect against the disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“while Aβ42 was shown to impair the function of the excitatory amino acid transporter (GLT-1) and the glutamate/aspartate transporter (GLAST) in hippocampal astrocytes [12].”
From Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease (2022) · cites this paper as [12]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Statistical Principles in Experimental Design
Green, P. E., Winer, B. J., Brown, D. R., & Michels, K. M. (1992) · Journal of Marketing Research · doi:10.2307/3172747 · Cited by 4,333
Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1
Tanaka, K., Watase, K., Manabe, T., Yamada, K., Watanabe, M., Takahashi, K., Iwama, H., Nishikawa, T., Ichihara, N., Kikuchi, T., et al. (1997) · Science · doi:10.1126/science.276.5319.1699 · Cited by 1,755
Primary structure and functional characterization of a high-affinity glutamate transporter
Kanai, Y., & Hediger, M. A. (1992) · Nature · doi:10.1038/360467a0 · Cited by 1,337
In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis
Stine, W. B., Dahlgren, K. N., Krafft, G. A., & LaDu, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210207200 · Cited by 1,015
Chaudhry, F. A., Lehre, K. P., Campagne, M. V. L., Ottersen, O. P., Danbolt, N. C., & Storm‐Mathisen, J. (1995) · Neuron · doi:10.1016/0896-6273(95)90158-2 · Cited by 838
Felipo, V., & Butterworth, R. F. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00019-9 · Cited by 626
Neuronal Regulation of Glutamate Transporter Subtype Expression in Astrocytes
Swanson, R. A., Liu, J., Miller, J. W., Rothstein, J. D., Farrell, K., Stein-Behrens, B., & Longuemare, M. C. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-03-00932.1997 · Cited by 500
Brain Glutamate Transporter Proteins Form Homomultimers
Haugeto, Ø., Ullensvang, K., Levy, L. M., Chaudhry, F. A., Honoré, T., Nielsen, M., Lehre, K. P., & Danbolt, N. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27715 · Cited by 497
Deficient glutamate tranport is associated with neurodegeneration in Alzheimer's disease
Masliah, E., Hansen, L., Alford, M., Deteresa, R., & Mallory, M. (1996) · Annals of Neurology · doi:10.1002/ana.410400512 · Cited by 476
Transporters Buffer Synaptically Released Glutamate on a Submillisecond Time Scale
Diamond, J. S., & Jahr, C. E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04672.1997 · Cited by 476
Self-citation
Cited by
Sorted by citations
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994
Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?
Lewerenz, J., & Maher, P. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00469 · Cited by 759
Banks, W. A., Gray, A. M., Erickson, M. A., Salameh, T. S., Damodarasamy, M., Sheibani, N., Meabon, J. S., Wing, E. E., Morofuji, Y., Cook, D. G., et al. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0434-1 · Cited by 636
Self-citationExtrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders
Parsons, M. P., & Raymond, L. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.030 · Cited by 567
Elusive roles for reactive astrocytes in neurodegenerative diseases
Ben Haim, L., Carrillo-de Sauvage, M.-A., Ceyzériat, K., & Escartin, C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00278 · Cited by 453
Metadata
- Authors
- Scimemi, A., Meabon, J. S., Woltjer, R. L., Sullivan, J. M., Diamond, J. S., & Cook, D. G.
- Affiliations
- National Institutes of Health (US)
- VA Puget Sound Health Care System (US)
- Oregon Health & Science University (US)
- University of Washington (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-03-20
- Volume
- 33
- Issue
- 12
- Pages
- 5312-5318
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3866500
- OpenAlex
- W1979889191
- Cited by
- 185
- References
- 28
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 23 · 2023: 9 · 2022: 22 · 2021: 15 · 2020: 18 · 2019: 12 · 2018: 11 · 2017: 19 · 2016: 7 · 2015: 13 · 2014: 11 · 2013: 1
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (T32AG000258)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK017047)
- National Institute of Neurological Disorders and Stroke (R01NS055804, ZIANS002986, Z01NS002986)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- amyloid-beta 42, GLT-1, glutamate transporters, astrocytes, glutamate clearance, Alzheimer's disease, Trolox, vitamin E, extracellular glutamate
- MeSH terms
- Alzheimer Disease, Animals, Antioxidants, Astrocytes, Chromans, Drug Interactions, Extracellular Space, Female, Hippocampus, Male, Mice, Inbred C57BL, Models, Neurological, Neurons, Organ Culture Techniques, Peptide Fragments, Synapses, Amyloid beta-Peptides, Glutamic Acid, Excitatory Amino Acid Transporter 2, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
