Elusive roles for reactive astrocytes in neurodegenerative diseases
Open accessAbstract
Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory response. They become reactive in response to virtually all pathological situations in the brain such as axotomy, ischemia, infection, and neurodegenerative diseases (ND). Astrocyte reactivity was originally characterized by morphological changes (hypertrophy, remodeling of processes) and the overexpression of the intermediate filament glial fibrillary acidic protein (GFAP). However, it is unclear how the normal supportive functions of astrocytes are altered by their reactive state. In ND, in which neuronal dysfunction and astrocyte reactivity take place over several years or decades, the issue is even more complex and highly debated, with several conflicting reports published recently. In this review, we discuss studies addressing the contribution of reactive astrocytes to ND. We describe the molecular triggers leading to astrocyte reactivity during ND, examine how some key astrocyte functions may be enhanced or altered during the disease process, and discuss how astrocyte reactivity may globally affect ND progression. Finally we will consider the anticipated developments in this important field. With this review, we aim to show that the detailed study of reactive astrocytes may open new perspectives for ND.
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MAO subtypes are expressed by both neurons and reactive astrocytes.
“MAO subtypes are expressed by both neurons (MAOA, especially in basal ganglia) and reactive astrocytes (mainly MAOB) (Fowler et al., 2005; Ben Haim et al., 2015).”
From Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum (2020) · cites this paper as Ben Haim et al., 2015
Astrocytes are another major immune-competent cell population in the brain, and have long been proposed to play a role in neurodegeneration.
“Astrocytes are another major immune-competent cell population in the brain, and have long been proposed to play a role in neurodegeneration (Ben Haim et al., 2015; Liddelow et al., 2017).”
From Overexpressing low‐density lipoprotein receptor reduces tau‐associated neurodegeneration in relation to apoE‐linked mechanisms (2021) · cites this paper as Ben Haim et al., 2015
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- Authors
- Ben Haim, L., Carrillo-de Sauvage, M.-A., Ceyzériat, K., & Escartin, C.
- Affiliations
- Université Paris-Sud (FR)
- Corresponding author
- Escartin, Carole
- ORCID
- Escartin, Carole
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-08-03
- Volume
- 9
- Pages
- 278-278
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4522610
- OpenAlex
- W1569924411
- Cited by
- 453
- References
- 309
- Citations by year
- 2026: 19 · 2025: 35 · 2024: 39 · 2023: 35 · 2022: 41 · 2021: 57 · 2020: 46 · 2019: 46 · 2018: 55 · 2017: 43 · 2016: 34 · 2015: 3
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agence Nationale de la Recherche (ANR-10-JCJC-1402, 2011-BSV4-021-03)
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- reactive astrocytes, astrocyte activation, neurodegenerative diseases, neuroinflammation, glial fibrillary acidic protein, astrocyte function, disease progression
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