The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Cerebral Blood Flow in Immediate and Sustained Anxiety
Open accessAbstract
The goal of this study was to compare cerebral blood flow (CBF) changes associated with phasic cued fear versus those associated with sustained contextual anxiety. Positron emission tomography images of CBF were acquired using [O-15]H2O in 17 healthy human subjects as they anticipated unpleasant electric shocks that were administered predictably (signaled by a visual cue) or unpredictably (threatened by the context). Presentation of the cue in either threat condition was associated with increased CBF in the left amygdala. A cue that specifically predicted the shock was associated with CBF increases in the ventral prefrontal cortex (PFC), hypothalamus, anterior cingulate cortex, left insula, and bilateral putamen. The sustained threat context increased CBF in the right hippocampus, mid-cingulate gyrus, subgenual PFC, midbrain periaqueductal gray, thalamus, bilateral ventral striatum, and parieto-occipital cortex. This study showed distinct neuronal networks involved in cued fear and contextual anxiety underlying the importance of this distinction for studies on the pathophysiology of anxiety disorders.
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“Hasler et al. (2007) found that a visual threat cue increased cerebral blood flow in the left amygdala relative to a comparable safe cue.”
From Phasic and sustained fear in humans elicits distinct patterns of brain activity (2011) · cites this paper as Hasler et al. (2007)
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“Previous studies of instructed fear using simple threat cues (e.g., colored squares) have associated phasic fear responses with a left hemisphere bias (Phelps et al., 2001; Funayama et al., 2001; Hasler et al., 2007).”
From Phasic and sustained fear in humans elicits distinct patterns of brain activity (2011) · cites this paper as Hasler et al., 2007
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“The finding that unpredictable threat induced sustained activity of frontoparietal areas involved in sustained attention (Pardo et al., 1991), is consistent with previous neuroimaging studies linking unpredictable threat to hypervigilance (Carlsson et al., 2006; Hasler et al., 2007).”
From Phasic and sustained fear in humans elicits distinct patterns of brain activity (2011) · cites this paper as Hasler et al., 2007
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Metadata
- Authors
- Hasler, G., Fromm, S., Alvarez, R. P., Luckenbaugh, D. A., Drevets, W. C., & Grillon, C.
- Affiliations
- University Hospital Zurich (CH)
- National Institutes of Health (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-06-06
- Volume
- 27
- Issue
- 23
- Pages
- 6313-6319
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2713601
- OpenAlex
- W1968966534
- Cited by
- 163
- References
- 43
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 8 · 2021: 8 · 2020: 6 · 2019: 10 · 2018: 9 · 2017: 5 · 2016: 9 · 2015: 7 · 2014: 13 · 2013: 12 · 2012: 10
- FWCI
- 14.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (Z01MH002798)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- cerebral blood flow, anxiety, fear, cued fear, amygdala, ventral prefrontal cortex, hippocampus, periaqueductal gray, threat anticipation, anxiety disorders, brain networks
- MeSH terms
- Adult, Anxiety, Blood Circulation Time, Blood Flow Velocity, Cerebrovascular Circulation, Fear, Female, Humans, Male, Middle Aged, Nerve Net, Time Factors, Positron-Emission Tomography
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