The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Cerebral Blood Flow in Immediate and Sustained Anxiety
Open accessAbstract
The goal of this study was to compare cerebral blood flow (CBF) changes associated with phasic cued fear versus those associated with sustained contextual anxiety. Positron emission tomography images of CBF were acquired using [O-15]H2O in 17 healthy human subjects as they anticipated unpleasant electric shocks that were administered predictably (signaled by a visual cue) or unpredictably (threatened by the context). Presentation of the cue in either threat condition was associated with increased CBF in the left amygdala. A cue that specifically predicted the shock was associated with CBF increases in the ventral prefrontal cortex (PFC), hypothalamus, anterior cingulate cortex, left insula, and bilateral putamen. The sustained threat context increased CBF in the right hippocampus, mid-cingulate gyrus, subgenual PFC, midbrain periaqueductal gray, thalamus, bilateral ventral striatum, and parieto-occipital cortex. This study showed distinct neuronal networks involved in cued fear and contextual anxiety underlying the importance of this distinction for studies on the pathophysiology of anxiety disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Hasler et al. (2007) found that a visual threat cue increased cerebral blood flow in the left amygdala relative to a comparable safe cue.”
From Phasic and sustained fear in humans elicits distinct patterns of brain activity (2011) · cites this paper as Hasler et al. (2007)
In the citing paper
“Previous studies of instructed fear using simple threat cues (e.g., colored squares) have associated phasic fear responses with a left hemisphere bias (Phelps et al., 2001; Funayama et al., 2001; Hasler et al., 2007).”
From Phasic and sustained fear in humans elicits distinct patterns of brain activity (2011) · cites this paper as Hasler et al., 2007
In the citing paper
“The finding that unpredictable threat induced sustained activity of frontoparietal areas involved in sustained attention (Pardo et al., 1991), is consistent with previous neuroimaging studies linking unpredictable threat to hypervigilance (Carlsson et al., 2006; Hasler et al., 2007).”
From Phasic and sustained fear in humans elicits distinct patterns of brain activity (2011) · cites this paper as Hasler et al., 2007
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565
Gray, J. A. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00013066 · Cited by 4,477
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
Phelps, E. A., & LeDoux, J. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.025 · Cited by 3,203 · cited 3×
“…fear responses via anatomical projections to a network underlying fear-related memory, reflex, and endocrine responses including the central nucleus of the amygdala, hypothalamus, brain stem nuclei, striatum, and medial and orbital prefrontal cortices (Davis, 2004; Phelps and LeDoux, 2005).”
BackgroundOngur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Valid conjunction inference with the minimum statistic
Nichols, T. E., Brett, M., Andersson, J., Wager, T. D., & Poline, J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.12.005 · Cited by 1,854
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836 · cited 1×
“The negative correlation between cuerelated anxiety levels and CBF in the infralimbic cortex is consistent with studies in rats (Milad and Quirk, 2002) demonstrating that pairing conditioned threat cues with brief infralimbic stimulation reduced fear.”
Result
Research works printed but not linked: 4
- Charney DS, Drevets WC (2002) Neurobiological basis of anxiety disorders. In: Neuropsychopharmacology: the fifth generation of progress (Davis KL, Charney DS, Coyle JT, Nemeroff CB, eds), pp 901-930. Philadelphia: Lippincott.
- Davis M (2004) Functional neuroanatomy of anxiety and fear. In: Neurobi- ology of mental illness, Ed 2 (Charney DS, Nestler EJ, eds), pp 584 -604. Oxford: Oxford UP.
- First MB, Gibbon M, Spitzer RL, Williams JBW (1996) Structured clinical interview for DSM-IV axis I disorders: nonpatient edition (SCID-I/NP). New York: New York State Psychiatric Institute.
- Gray JA (1982) The neuropsychology of anxiety: an enquiry in to the func- tions of the septo-hippocampal system. Oxford: Oxford UP.
Cited by
Sorted by citations
Hölzel, B. K., Lazar, S. W., Gard, T., Schuman-Olivier, Z., Vago, D. R., & Ott, U. (2011) · Perspectives on Psychological Science · doi:10.1177/1745691611419671 · Cited by 3,024
“The amygdala has been implicated in both human and animal studies as playing a crucial role during the acquisition and expression of conditioned fear (Davis & Whalen, 2001; LeDoux, 2000; Pare, Quirk, & Ledoux, 2004; Phelps & LeDoux, 2005), including the detection of stressful and threatening stimuli and the initiation…”
The contextual brain: implications for fear conditioning, extinction and psychopathology
Maren, S., Phan, K. L., & Liberzon, I. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3492 · Cited by 1,547
The Role of Emotion Regulation in Autism Spectrum Disorder
Mazefsky, C. A., Herrington, J., Siegel, M., Scarpa, A., Maddox, B. B., Scahill, L., & White, S. W. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.05.006 · Cited by 881
Hippocampal synaptic plasticity, spatial memory and anxiety
Bannerman, D. M., Sprengel, R., Sanderson, D. J., McHugh, S. B., Rawlins, J. N. P., Monyer, H., & Seeburg, P. H. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3677 · Cited by 688
Pathophysiology of depression: do we have any solid evidence of interest to clinicians?
HASLER, G. (2010) · World Psychiatry · doi:10.1002/j.2051-5545.2010.tb00298.x · Cited by 604
Self-citation
Metadata
- Authors
- Hasler, G., Fromm, S., Alvarez, R. P., Luckenbaugh, D. A., Drevets, W. C., & Grillon, C.
- Affiliations
- University Hospital Zurich (CH)
- National Institutes of Health (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-06-06
- Volume
- 27
- Issue
- 23
- Pages
- 6313-6319
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2713601
- OpenAlex
- W1968966534
- Cited by
- 163
- References
- 43
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 8 · 2021: 8 · 2020: 6 · 2019: 10 · 2018: 9 · 2017: 5 · 2016: 9 · 2015: 7 · 2014: 13 · 2013: 12 · 2012: 10
- FWCI
- 14.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (Z01MH002798)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- cerebral blood flow, anxiety, fear, cued fear, amygdala, ventral prefrontal cortex, hippocampus, periaqueductal gray, threat anticipation, anxiety disorders, brain networks
- MeSH terms
- Adult, Anxiety, Blood Circulation Time, Blood Flow Velocity, Cerebrovascular Circulation, Fear, Female, Humans, Male, Middle Aged, Nerve Net, Time Factors, Positron-Emission Tomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
