Hippocampal synaptic plasticity, spatial memory and anxiety

Bannerman, David M.; Sprengel, Rolf; Sanderson, David J.; McHugh, Stephen B.; Rawlins, J. Nicholas P.; Monyer, Hannah; Seeburg, Peter H.

doi:10.1038/nrn3677

Cited by 688Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Hippocampal synaptic plasticity, spatial memory and anxiety

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Bannerman, David M., Sprengel, Rolf, Sanderson, David J., McHugh, Stephen B., Rawlins, J. Nicholas P., Monyer, Hannah, Seeburg, Peter H.·2014·Nature Reviews Neuroscience

DOI 10.1038/nrn3677

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Abstract

Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.

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The ventral hippocampus is a candidate region for the anxiety-related effects of chronic restraint stress given prior evidence implicating this region in anxiety-related behavior.
“The vHPC represents one obvious candidate for these effects given prior evidence implicating this region in anxiety-related behavior (38).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [38]
Forming an episodic memory involves the association of an event or feature with a particular location in space and occurs through the long-term potentiation mechanism in the hippocampus.
“Forming an episodic memory involves the association of an event or feature with a particular location in space and occurs through this LTP mechanism in the hippocampus (Bannerman et al., 2014).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Bannerman et al., 2014

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Authors: Bannerman, D. M., Sprengel, R., Sanderson, D. J., McHugh, S. B., Rawlins, J. N. P., Monyer, H., & Seeburg, P. H.
Affiliations: University of Oxford (GB)
Max Planck Society (DE)
Durham University (GB)
German Cancer Research Center (DE)
Corresponding author: Bannerman, David M.
Seeburg, Peter H.
ORCID: Bannerman, David M.
Sprengel, Rolf
Sanderson, David J.
McHugh, Stephen B.
Monyer, Hannah
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2014-02-20
Volume: 15
Issue: 3
Pages: 181-192
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3677
OpenAlex: W1997396304
Semantic Scholar: b0b47c28536f3f65d47e2aaf99216b4f61b01ca8
Cited by: 688
References: 159
Citations by year: 2026: 25 · 2025: 50 · 2024: 71 · 2023: 64 · 2022: 55 · 2021: 71 · 2020: 60 · 2019: 65 · 2018: 67 · 2017: 57 · 2016: 39 · 2015: 49 · 2014: 14
FWCI: 5.13
Type: journal article
Language: en
Open access: green
durham-repository.worktribe.com
Licence: other-oa
www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Durham Research Online (Durham University) (acceptedVersion)
Durham Research Online (Durham University) (acceptedVersion, other-oa)
Durham Research Online (Durham University) (submittedVersion, cc-by)
Max Planck Digital Library (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: Wellcome Trust (084655, 087736, 074385)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: hippocampus, synaptic plasticity, spatial memory, anxiety, NMDA receptor, long-term potentiation, spatial learning, memory encoding, conflict resolution, uncertainty, transgenic mice
MeSH terms: Animals, Anxiety, Behavior, Animal, Hippocampus, Memory, Synaptic Transmission, Neuronal Plasticity, Space Perception, Synapses, Receptors, N-Methyl-D-Aspartate, Mice, Knockout, Mice

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Hippocampal synaptic plasticity, spatial memory and anxiety

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