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Sensory Deprivation Alters Aggrecan and Perineuronal Net Expression in the Mouse Barrel Cortex
Open accessAbstract
An important role for the neural extracellular matrix in modulating cortical activity-dependent synaptic plasticity has been established by a number of recent studies. However, identification of the critical molecular components of the neural matrix that mediate these processes is far from complete. Of particular interest is the perineuronal net (PN), an extracellular matrix component found surrounding the cell body and proximal neurites of a subset of neurons. Because of the apposition of the PN to synapses and expression of this structure coincident with the close of the critical period, it has been hypothesized that nets could play uniquely important roles in synapse stabilization and maturation. Interestingly, previous work has also shown that expression of PNs is dependent on appropriate sensory stimulation in the visual system. Here, we investigated whether PNs in the mouse barrel cortex are expressed in an activity-dependent manner by manipulating sensory input through whisker trimming. Importantly, this manipulation did not lead to a global loss of PNs but instead led to a specific decrease in PNs, detected with the antibody Cat-315, in layer IV of the barrel cortex. In addition, we identified a key activity-regulated component of PNs is the proteoglycan aggrecan. We also demonstrate that these Cat-315-positive neurons virtually all also express parvalbumin. Together, these data are in support of an important role for aggrecan in the activity-dependent formation of PNs on parvalbumin-expressing cells and suggest a role for expression of these nets in regulating the close of the critical period.
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In the citing paper
“CSPG-enriched PNNs form in an activity-dependent manner during late postnatal development, completing neuronal maturation.32, 33, 34”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [32]
In the citing paper
“The role of ECM in cortical plasticity has been previously reported (Pizzorusso et al. 2002;Nagy et al. 2006;McRae et al. 2007;Rivera et al. 2010)”
From Genetic Reduction of Matrix Metalloproteinase-9 Promotes Formation of Perineuronal Nets Around Parvalbumin-Expressing Interneurons and Normalizes Auditory Cortex Responses in Developing Fmr1 Knock-Out Mice (2018) · cites this paper as McRae et al. 2007
In the citing paper
“the expression of PNNs in the mouse barrel cortex during development was dependent on appropriate sensory stimulation (McRae et al., 2007)”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as McRae et al., 2007
In the citing paper
“Sensory deprivation in adult mice, however, did not alter aggrecan expression, indicating that once established, maintenance of PNNs does not require normal sensory input (McRae et al., 2007)”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as McRae et al., 2007
In the citing paper
“sensory deprivation by whisker trimming within the first 30 days of birth was found to decrease the number of aggrecan-positive PNNs around parvalbumin-expressing cells in layer IV of the mouse barrel cortex and prolong the critical period (McRae et al., 2007)”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as McRae et al., 2007
In the citing paper
“its expression is dependent on neuronal activity during a maturationally based ‘critical period’”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as McRae et al., 2007
In the citing paper
“The organization of specific ECM molecules into PNNs in vivo requires the presence of appropriate stimuli and occurs during postnatal development, in concomitance with the end of the critical period for experience-dependent plasticity (Carulli et al., 2010;Kalb and Hockfield, 1990;McRae et al., 2007;Pizzorusso et al., 2002;Ye and Miao, 2013).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as McRae et al., 2007
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Metadata
- Authors
- McRae, P. A., Rocco, M. M., Kelly, G., Brumberg, J. C., & Matthews, R. T.
- Affiliations
- Yale University (US)
- The Graduate Center, CUNY (US)
- Queens College, CUNY (US)
- SUNY Upstate Medical University (US)
- Corresponding author
- Matthews, Russell T.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-05-16
- Volume
- 27
- Issue
- 20
- Pages
- 5405-5413
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6672348
- OpenAlex
- W1985654472
- Cited by
- 272
- References
- 50
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 8 · 2023: 11 · 2022: 20 · 2021: 18 · 2020: 14 · 2019: 17 · 2018: 18 · 2017: 22 · 2016: 10 · 2015: 20 · 2014: 23 · 2013: 9 · 2012: 14
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CUNY Academic Works (City University of New York) (submittedVersion, cc-by)
- Funders
- American Psychological Association
- National Institute of Neurological Disorders and Stroke (NS 007224-21S1, T32NS007224)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- perineuronal nets, aggrecan, sensory deprivation, whisker trimming, barrel cortex, parvalbumin, extracellular matrix, activity-dependent synaptic plasticity, critical period, layer 4, proteoglycans
- MeSH terms
- Animals, Animals, Newborn, Cerebral Cortex, Extracellular Matrix, Neuronal Plasticity, Sensory Deprivation, Vibrissae, Gene Expression Regulation, Developmental, Mice, Aggrecans
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