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Regulation of Radial Glial Survival by Signals from the Meninges
Open accessAbstract
Radial glial cells (RGCs) in the developing cerebral cortex are progenitors for neurons and glia, and their processes serve as guideposts for migrating neurons. So far, it has remained unclear whether RGC processes also control the function of RGCs more directly. Here, we show that RGC numbers and cortical size are reduced in mice lacking beta1 integrins in RGCs. TUNEL stainings and time-lapse video recordings demonstrate that beta1-deficient RGCs processes detach from the meningeal basement membrane (BM) followed by apoptotic death of RGCs. Apoptosis is also induced by surgical removal of the meninges. Finally, mice lacking the BM components laminin alpha2 and alpha4 show defects in the attachment of RGC processes at the meninges, a reduction in cortical size, and enhanced apoptosis of RGC cells. Our findings demonstrate that attachment of RGC processes at the meninges is important for RGC survival and the control of cortical size.
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“GPR56 likely influences progenitor proliferation by stabilizing the basal process of radial neuroepithelial progenitors”
From Evolutionarily Dynamic Alternative Splicing of GPR56 Regulates Regional Cerebral Cortical Patterning (2014) · cites this paper as [22]
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Metadata
- Authors
- Radakovits, R., Barros, C. S., Belvindrah, R., Patton, B., & Muller, U.
- Affiliations
- Scripps Research Institute (US)
- Oregon Health & Science University (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-06-17
- Volume
- 29
- Issue
- 24
- Pages
- 7694-7705
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2738639
- OpenAlex
- W1977060481
- Cited by
- 135
- References
- 54
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 15 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 8 · 2015: 8 · 2014: 16 · 2013: 9 · 2012: 8
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- PEARL (University of Plymouth) (submittedVersion)
- Funders
- Christopher and Dana Reeve Foundation
- California Institute of Regenerative Medicine
- National Institutes of Health
- National Institute of Mental Health (MH078833, U01MH078833)
- National Institute of Neurological Disorders and Stroke (NS046456, R01NS046456)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- radial glia, beta1 integrin, apoptosis, laminin alpha 2, laminin α4, cortical development, neuronal migration, glial progenitors
- MeSH terms
- PAX6 Transcription Factor, Animals, Animals, Newborn, Bromodeoxyuridine, Cell Differentiation, Cell Survival, Cerebral Cortex, Embryo, Mammalian, Eye Proteins, Intermediate Filament Proteins, Laminin, Meninges, Mice, Transgenic, Nerve Tissue Proteins, Neuroglia, Repressor Proteins, Stem Cells, Signal Transduction, Electroporation, Homeodomain Proteins, Gene Expression Regulation, Developmental, Integrin beta1, Integrases, In Situ Nick-End Labeling, Cell Proliferation, Green Fluorescent Proteins, Mice, Paired Box Transcription Factors, Neurogenesis, Nestin, In Vitro Techniques
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