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Lack of Pathology in a Triple Transgenic Mouse Model of Alzheimer’s Disease after Overexpression of the Anti-Apoptotic Protein Bcl-2
Open accessAbstract
Alzheimer's disease (AD) is characterized by the accumulation of plaques containing beta-amyloid (Abeta) and neurofibrillary tangles (NFTs) consisting of modified tau. Although Abeta deposition is thought to precede the formation of NFTs in AD, the molecular steps connecting these two pathologies is not known. Previous studies have suggested that caspase activation plays an important role in promoting the pathology associated with AD. To further understand the contribution of caspases in disease progression, a triple transgenic Alzheimer's mouse model overexpressing the anti-apoptotic protein Bcl-2 was generated. Here we show that overexpression of Bcl-2 limited caspase-9 activation and reduced the caspase cleavage of tau. Moreover, overexpression of Bcl-2 attenuated the processing of APP (amyloid precursor protein) and tau and reduced the number of NFTs and extracellular deposits of Abeta associated with these animals. In addition, overexpression of Bcl-2 in 3xTg-AD mice improved place recognition memory. These findings suggest that the activation of apoptotic pathways may be an early event in AD and contributes to the pathological processes that promote the disease mechanisms underlying AD.
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“Recent evidence suggests that executioner caspases 3 and 7 may contribute to tau, the protein responsible for forming NFTs, pathology by cleaving tau after Asp421 to yield a cytotoxic Δtau fragment (Rissman et al., 2004; Rohn et al., 2008; de Calignon et al., 2010).”
From The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease (2011) · cites this paper as Rohn et al., 2008
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“Interestingly, staining with Fluoro Jade C, a marker for degenerating neurons, did not reveal evidence for neurodegeneration [109] and a quantitative analysis of CA1 neuron numbers revealed a lack of neuron loss in this brain region in 3xTg mice during aging [110].”
From Neuron Loss in Alzheimer’s Disease: Translation in Transgenic Mouse Models (2020) · cites this paper as [109]
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Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126
Cell death during development of the nervous system
Oppenheim, R. W. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002321 · Cited by 3,084
Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859
Molecular mechanisms of caspase regulation during apoptosis
Riedl, S. J., & Shi, Y. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1496 · Cited by 1,933
Vaux, D. L., & Korsmeyer, S. J. (1999) · Cell · doi:10.1016/s0092-8674(00)80564-4 · Cited by 1,564
Martinou, J., Dubois‐Dauphin, M., Staple, J. K., Rodríguez, I., Frankowski, H., Missotten, M., Albertini, P., Talabot, D., Catsicas, S., & Pietra, C. (1994) · Neuron · doi:10.1016/0896-6273(94)90266-6 · Cited by 1,087
Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease
Gamblin, T. C., Chen, F., Zambrano, A., Abraha, A., Lagalwar, S., Guillozet, A. L., Lu, M., Fu, Y., Garcia-Sierra, F., LaPointe, N., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1630428100 · Cited by 831
Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts
Mumby, D. G., Gaskin, S., Glenn, M. J., Schramek, T. E., & Lehmann, H. (2002) · Learning & Memory · doi:10.1101/lm.41302 · Cited by 714
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Effects of asiaticoside on human umbilical vein endothelial cell apoptosis induced by Aβ1-42.
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Li, K., Wang, Z., Zhang, J., & Lv, P. (2020) · Archives of Medical Science · doi:10.5114/aoms.2020.94490 · Cited by 5
Flütsch, A., & Grütter, M. G. (2013) · Springer eBooks · doi:10.1007/978-3-7091-0885-7_8 · Cited by 4
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Dai, C.-L., Song, Y., Chen, Y., Tung, Y. C., Huang, W., Gong, C., & Lovell, J. F. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101167 · Cited by 1
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Zaid, O. A. A., Hussein, S., El-Sonbaty, S., & Afifi, M. (2021) · Benha veterinary medical journal · doi:10.21608/bvmj.2021.73288.1401 · Cited by 1
Deng, L., Zhang, J., Cao, K., Shang, M., & Han, F. (2022) · International Conference on Computing and Pattern Recognition (ICCPR) · doi:10.1145/3581807.3581884 · Cited by 1
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Alkhazaali-Ali, Z., Negah, S. S., Boroumand, A. R., & Afshari, J. T. (2024) · Preprints.org · doi:10.20944/preprints202404.0366.v1 · Cited by 1
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Self-citationCrunfli, F. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2018.tde-14032018-110624
Canty, A. J., Jackson, J., Huang, L., Trabalza, A., Bass, C., Little, G. E., & Paola, V. D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/391425
Yagensky, O., Kohansal-Nodehi, M., Gunaseelan, S., Rabe, T., Zafar, S., Zerr, I., Härtig, W., Urlaub, H., & Chua, J. J. E. (2019) · eLife · doi:10.7554/elife.47498.031
Panigrahi, S., Surai, S., & Hong, H. (2020) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2020.v13i3.37106
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Laumet, G. O. (2010) · theses.fr (ABES) · doi:10.70675/94126786zf990z488ezb471z5f1d5686766c
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Metadata
- Authors
- Rohn, T. T., Vyas, V., Hernandez-Estrada, T., Nichol, K. E., Christie, L.-A., & Head, E.
- Affiliations
- Boise State University (US)
- University of California, Irvine (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-03-19
- Volume
- 28
- Issue
- 12
- Pages
- 3051-3059
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6670712
- OpenAlex
- W2086662417
- Cited by
- 146
- References
- 43
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 9 · 2017: 2 · 2016: 10 · 2015: 6 · 2014: 9 · 2013: 7 · 2012: 8
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ScholarWorks (Boise State University) (submittedVersion)
- Funders
- American Health Assistance Foundation
- National Institutes of Health (AG16573)
- Directorate for Biological Sciences
- University of California, Irvine (P20RR016454, P50 AG16573)
- National Research Council Canada
- National Institute on Aging (P50 AG 16573, P50AG016573)
- National Center for Research Resources (P50 AG16573, P20RR016454)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, Bcl-2, caspase-9, apoptosis, neurofibrillary tangles, amyloid plaques, tau cleavage, APP processing, 3xTg-AD mice, triple transgenic mouse model
- MeSH terms
- Alzheimer Disease, Amyloid, Animals, Behavior, Animal, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Fluoresceins, Gene Expression Regulation, Humans, Memory, Mice, Transgenic, Organic Chemicals, Amyloid beta-Protein Precursor, tau Proteins, Proto-Oncogene Proteins c-bcl-2, Caspases, Infarction, Middle Cerebral Artery, Mice, Presenilin-1
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