Cited by 146Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Lack of Pathology in a Triple Transgenic Mouse Model of Alzheimer’s Disease after Overexpression of the Anti-Apoptotic Protein Bcl-2

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Rohn, Troy T., Vyas, Veera, Hernandez-Estrada, Tatiana, Nichol, Kathryn E., Christie, Lori-Ann, Head, Elizabeth·2008·The Journal of Neuroscience

DOI 10.1523/jneurosci.5620-07.2008PMC PMC6670712

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Abstract

Alzheimer's disease (AD) is characterized by the accumulation of plaques containing beta-amyloid (Abeta) and neurofibrillary tangles (NFTs) consisting of modified tau. Although Abeta deposition is thought to precede the formation of NFTs in AD, the molecular steps connecting these two pathologies is not known. Previous studies have suggested that caspase activation plays an important role in promoting the pathology associated with AD. To further understand the contribution of caspases in disease progression, a triple transgenic Alzheimer's mouse model overexpressing the anti-apoptotic protein Bcl-2 was generated. Here we show that overexpression of Bcl-2 limited caspase-9 activation and reduced the caspase cleavage of tau. Moreover, overexpression of Bcl-2 attenuated the processing of APP (amyloid precursor protein) and tau and reduced the number of NFTs and extracellular deposits of Abeta associated with these animals. In addition, overexpression of Bcl-2 in 3xTg-AD mice improved place recognition memory. These findings suggest that the activation of apoptotic pathways may be an early event in AD and contributes to the pathological processes that promote the disease mechanisms underlying AD.

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Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
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Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126
Cell death during development of the nervous system
Oppenheim, R. W. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002321 · Cited by 3,084
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Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859
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Riedl, S. J., & Shi, Y. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1496 · Cited by 1,933
Cell Death in Development
Vaux, D. L., & Korsmeyer, S. J. (1999) · Cell · doi:10.1016/s0092-8674(00)80564-4 · Cited by 1,564
Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia
Martinou, J., Dubois‐Dauphin, M., Staple, J. K., Rodríguez, I., Frankowski, H., Missotten, M., Albertini, P., Talabot, D., Catsicas, S., & Pietra, C. (1994) · Neuron · doi:10.1016/0896-6273(94)90266-6 · Cited by 1,087
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Authors: Rohn, T. T., Vyas, V., Hernandez-Estrada, T., Nichol, K. E., Christie, L.-A., & Head, E.
Affiliations: Boise State University (US)
University of California, Irvine (US)
ORCID: Rohn, Troy T.
Head, Elizabeth
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2008-03-19
Volume: 28
Issue: 12
Pages: 3051-3059
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.5620-07.2008
PMC: PMC6670712
OpenAlex: W2086662417
Cited by: 146
References: 43
Citations by year: 2026: 3 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 9 · 2017: 2 · 2016: 10 · 2015: 6 · 2014: 9 · 2013: 7 · 2012: 8
FWCI: 9.28
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
ScholarWorks (Boise State University) (submittedVersion)
Funders: American Health Assistance Foundation
National Institutes of Health (AG16573)
Directorate for Biological Sciences
University of California, Irvine (P20RR016454, P50 AG16573)
National Research Council Canada
National Institute on Aging (P50 AG 16573, P50AG016573)
National Center for Research Resources (P50 AG16573, P20RR016454)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, Bcl-2, caspase-9, apoptosis, neurofibrillary tangles, amyloid plaques, tau cleavage, APP processing, 3xTg-AD mice, triple transgenic mouse model
MeSH terms: Alzheimer Disease, Amyloid, Animals, Behavior, Animal, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Fluoresceins, Gene Expression Regulation, Humans, Memory, Mice, Transgenic, Organic Chemicals, Amyloid beta-Protein Precursor, tau Proteins, Proto-Oncogene Proteins c-bcl-2, Caspases, Infarction, Middle Cerebral Artery, Mice, Presenilin-1

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Lack of Pathology in a Triple Transgenic Mouse Model of Alzheimer’s Disease after Overexpression of the Anti-Apoptotic Protein Bcl-2

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