The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
TRPA1 Channels Are Regulators of Astrocyte Basal Calcium Levels and Long-Term Potentiation via Constitutive D-Serine Release
Open accessAbstract
Astrocytes are found throughout the brain where they make extensive contacts with neurons and synapses. Astrocytes are known to display intracellular Ca(2+) signals and release signaling molecules such as D-serine into the extracellular space. However, the role(s) of astrocyte Ca(2+) signals in hippocampal long-term potentiation (LTP), a form of synaptic plasticity involved in learning and memory, remains unclear. Here, we explored a recently discovered novel TRPA1 channel-mediated transmembrane Ca(2+) flux pathway in astrocytes. Specifically, we determined whether block or genetic deletion of TRPA1 channels affected LTP of Schaffer collateral to CA1 pyramidal neuron synapses. Using pharmacology, TRPA1(-/-) mice, imaging, electrophysiology, and D-serine biosensors, our data indicate that astrocyte TRPA1 channels contribute to basal Ca(2+) levels and are required for constitutive D-serine release into the extracellular space, which contributes to NMDA receptor-dependent LTP. The findings have broad relevance for the study of astrocyte-neuron interactions by demonstrating how TRPA1 channel-mediated fluxes contribute to astrocyte basal Ca(2+) levels and neuronal function via constitutive D-serine release.
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Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129
Long-term potentiation depends on release of d-serine from astrocytes
Henneberger, C., Papouin, T., Oliet, S. H. R., & Rusakov, D. A. (2010) · Nature · doi:10.1038/nature08673 · Cited by 1,389
Schell, M. J., Molliver, M. E., & Snyder, S. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3948 · Cited by 832
Schell, M. J., Brady Jr., R. O., Molliver, M. E., & Snyder, S. H. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01604.1997 · Cited by 415 · cited 4×
“Along these lines, our data suggest that D-serine levels in the CA1 region of the hippocampus are relatively high, perhaps because astrocytes in this region contain the highest amounts of D-serine (Schell et al., 1997).”
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Carlisle, H. J., Fink, A. E., Grant, S. G. N., & O’Dell, T. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.163469 · Cited by 172
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Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
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Metadata
- Authors
- Shigetomi, E., Jackson-Weaver, O., Huckstepp, R. T., O'Dell, T. J., & Khakh, B. S.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-06-12
- Volume
- 33
- Issue
- 24
- Pages
- 10143-10153
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1979044083
- Cited by
- 320
- References
- 6
- FWCI
- 13.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Shigetomi, E., Jackson-Weaver, O., Huckstepp, R. T., O'Dell, T. J., & Khakh, B. S. (2013). TRPA1 Channels Are Regulators of Astrocyte Basal Calcium Levels and Long-Term Potentiation via Constitutive D-Serine Release. Journal of Neuroscience. https://doi.org/10.1523/jneurosci.5779-12.2013
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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