Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,431

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

Open access
Pelegrin, Pablo, Surprenant, Annmarie·2006·The EMBO Journal
DOI 10.1038/sj.emboj.7601378
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/sj.emboj.7601378

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 8 references

Research works printed but not linked: 38

  1. Bao L, Locovei S, Dahl G (2004) Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett 572: 65–68 · DOI · Paper page
  2. Barbe MT, Monyer H, Bruzzone R (2006) Cell–cell communication beyond connexins: the pannexin channels. Physiology 21: 103–114 · DOI · Paper page
  3. Beyer EC, Steinberg TH (1991) Evidence that the gap junction protein connexin‐43 is the ATP‐induced pore of mouse macrophages. J Biol Chem 266: 7971–7974 · DOI · Paper page
  4. Bruzzone R, Barbe MT, Jakob NJ, Monyer H (2005) Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. J Neurochem 92: 1033–1043 · DOI · Paper page
  5. Buell G, Chessell IP, Michel AD, Collo G, Salazzo M, Herren S, Gretener D, Grahames C, Kaur R, Kosco‐Vilbois MH, Humphrey PP (1998) Blockade of human P2X7 receptor function with a monoclonal antibody. Blood 92: 3521–3528 · DOI · Paper page
  6. Chong LK, Suvarna K, Chess‐Williams R, Peachell PT (2003) Desensitization of β2‐adrenoceptor‐mediated responses by short‐acting β2‐adrenoceptor agonists in human lung mast cells. Br J Pharmacol 138: 512–520 · doi:10.1038/sj.bjp.0705050
  7. Dhein S (2004) Pharmacology of gap junctions in the cardiovascular system. Cardiovasc Res 62: 287–298 · DOI
  8. Dinarello CA (2005) Blocking IL‐1 in systemic inflammation. J Exp Med 201: 1355–1399 · DOI · Paper page
  9. Eguchi Y, Shimizu S, Tsujimoto Y (1997) Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res 57: 1835–1840
  10. Elliott JI, Surprenant A, Marelli‐Berg FM, Cooper JC, Cassady‐Cain RL, Wooding C, Linton K, Alexander DR, Higgins CF (2005) Membrane phosphatidylserine distribution as a non‐apoptotic signalling mechanism in lymphocytes. Nat Cell Biol 7: 808–816 · DOI · Paper page
  11. Faria RX, Defarias FP, Alves LA (2005) Are second messengers crucial for opening the pore associated with P2X7 receptor? Am J Physiol 288: C260–C270 · DOI
  12. Griffith TM, Chaytor AT, Edwards DH (2004) The obligatory link: role of gap junctional communication in endothelial dependent smooth muscle hyperpolarization. Pharmacol Res 49: 551–564 · DOI
  13. Gudipaty L, Munetz J, Verhoef PA, Dubyak GR (2003) Essential role for Ca2+ in regulation of IL‐1beta secretion by P2X7 nucleotide receptor in monocytes, macrophages and HEK‐293 cells. Am J Physiol 285: C286–C299 · DOI
  14. Han BS, Hong HS, Choi WS, Markelonis GJ, Oh TH, Oh YJ (2003) Caspase‐dependent and independent cell death pathways in primary cultures of mesencephalic dopaminergic neurons after neurotoxin treatment. J Neurosci 23: 5069–5078 · DOI
  15. Hickman SE, Semrad CE, Silverstein SC (1996) P2Z purinoceptors. Ciba Found Symp 198: 71–83
  16. Humphreys BD, Dubyak GR (1998) Modulation of P2X7 nucleotide receptor expression by pro‐ and anti‐inflammatory stimuli in THP‐1 monocytes. J Leukoc Biol 64: 265–273 · DOI
  17. Jiang LH, Rassendren F, Mackenzie A, Zhang YH, Surprenant A, North RA (2005) N‐methyl‐D‐glucamine and propidium dyes utilize different permeation pathways at rat P2X7 receptors. Am J Physiol 289: C1295–C1302 · DOI
  18. Kahlenberg JM, Dubyak GR (2004) Mechanisms of caspase‐1 activation by P2X7 receptor‐mediated K+ release. Am J Physiol 286: C1100–C1108 · DOI · Paper page
  19. Kanneganti TD, Ozoren N, Body‐Malapel M, Amer A, Park JH, Franchi L, Whitfield J, Barchet W, Colonna M, Vandenabeele P, Bertin J, Coyle A, Grant EP, Akira S, Nunez G (2006) Bacterial RNA and small antiviral compounds activate caspase‐1 through cryopyrine/Nalp3. Nature 440: 233–236 · DOI · Paper page
  20. Ke HZ, Qi H, Weidema AF, Zhang Q, Panupinthu N, Crawford DT, Grasser WA, Paralkar VM, Li M, Audoly LP, Gabel CA, Jee WS, Dixon SJ, Sims SM, Thompson DD (2003) Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol Endocrinol 17: 1356–1367 · DOI · Paper page
  21. Locovei S, Bao L, Dahl G (2006a) Pannexin 1 in erythrocytes: function without a gap. Proc Natl Acad Sci 103: 7655–7659 · DOI · Paper page
  22. Locovei S, Wang J, Dahl G (2006b) Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett 580: 239–244 · DOI · Paper page
  23. Mackenzie A, Wilson HL, Kiss‐Toth E, Dower SK, North RA, Surprenant A (2001) Rapid secretion of interleukin 1β by microvesicle shedding. Immunity 8: 825–835 · DOI · Paper page
  24. Mackenzie AB, Chirakkal H, North RA (2003) Kv1.3 potassium channels in human alveolar macrophage. Am J Physiol 285: L862–L868 · DOI
  25. Mackenzie AB, Young MT, Adinolfi E, Surprenant A (2005) Pseudoapoptosis induced by brief activation of ATP‐gated P2X7 receptors. J Biol Chem 280: 33968–33976 · DOI · Paper page
  26. Mariathasan S, Newton K, Monack DM, Vucic D, French DM, Lee WP, Roose‐Girma M, Erickson S, Dixit VM (2004) Differential activation of the inflammasome by caspase‐1 adaptors ASC and Ipaf. Nature 430: 213–218 · DOI · Paper page
  27. Martinon F, Tschopp J (2004) Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117: 561–574 · DOI · Paper page
  28. Morelli A, Chiozzi P, Chiesa A, Ferrari D, Sanz JM, Falzoni S, Pinton P, Rizzuto R, Olson MF, Di Virgilio F (2003) Extracellular ATP causes ROCK I‐dependent bleb formation in P2X7‐transfected HEK cells. Mol Biol Cell 14: 2655–2664 · DOI
  29. Nemeth K, Bugovics G, Skekely J (1997) Antiapoptotic effect of benzyloxycarbonyl‐aspartyl‐(β‐tertier‐butyl ester)‐bromomethylketone (Z‐D(OtBu)‐BMK), an intermediate of interleukin‐1β converting enzyme inhibitors. Int J Immunopharmacol 19: 215–225 · doi:10.1016/s0192-0561(97)00026-x
  30. Perregaux D, Gabel CA (1994) Interleukin‐1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necesary and common feature of their activity. J Biol Chem 269: 15195–15203 · DOI · Paper page
  31. Perregaux DG, Svensson L, Gabel CA (1996) Tenidap and other anion transport inhibitors disrupt cytolytic T lymphocyte‐mediated IL‐1 beta post‐translational processing. J Immunol 157: 57–64 · DOI
  32. Schilling WP, Wasylyna T, Dubyak GR, Humphreys BD, Sinkins WG (1999) Maitotoxin and P2Z/P2X7 purinergic receptor stimulation activate a common cytolytic pore. Am J Physiol 277: C766–C776 · DOI
  33. Solle M, Labasi J, Perregaux DG, Stam E, Petrushova N, Koller BH, Griffiths RJ, Gabel CA (2001) Altered cytokine production in mice lacking P2X7 receptors. J Biol Chem 276: 125–132 · DOI · Paper page
  34. Spray DC, Rozental R, Srinivas M (2002) Prospects for rational development of pharmacological gap junction channel blockers. Curr Drug Targets 3: 455–464 · DOI
  35. Steinberg TH, Di Virgilio F (1991) Cell‐mediated cytotoxicity: ATP as an effector and the role of target cells. Curr Opin Immmunol 3: 71–75 · DOI
  36. Suadicani SO, Brosnan CF, Scemes E (2006) P2X7 receptors mediate ATP release and amplification of astrocytic intracellular Ca2+ signaling. J Neurosci 26: 1378–1385 · DOI · Paper page
  37. Tarasov A, Dusonchet J, Ashcroft F (2004) Metabolic regulation of the pancreatic β‐cell ATP‐sensitive K+ channel. Diabetes 53: S113–S122 · DOI
  38. Thompson RJ, Zhou N, MacVicar BA (2006) Ischemia opens neuronal gap junction hemichannels. Science 312: 924–927 · DOI · Paper page

Cited by

See all 1,431

Metadata

Authors
Pelegrin, P., & Surprenant, A.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
2006-10-12
Volume
25
Issue
21
Pages
5071-5082
ISSN
  • 0261-4189 (ISSN-L)
  • 1460-2075
DOI
10.1038/sj.emboj.7601378
OpenAlex
W2102694854
Cited by
1,431
References
8
FWCI
42.15
Type
journal article
Language
en
Open access
bronze
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor. https://app.cochat.ai/papers/10.1038/sj.emboj.7601378
The paper
Pelegrin, P., & Surprenant, A. (2006). Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor. The EMBO Journal. https://doi.org/10.1038/sj.emboj.7601378

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.