The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Contrasting Roles for Dopamine D1 and D2 Receptor Subtypes in the Dorsomedial Striatum but Not the Nucleus Accumbens Core during Behavioral Inhibition in the Stop-Signal Task in Rats
Open accessAbstract
Dopamine and dopamine-receptor function are often implicated in behavioral inhibition, and deficiencies within behavioral inhibition processes linked to attention deficit/hyperactivity disorder (ADHD), schizophrenia, obsessive-compulsive disorder, and drug addiction. In the stop-signal task, which measures the speed of the process of inhibition [stop-signal reaction time (SSRT)], psychostimulant-related improvement of SSRT in ADHD is linked with dopamine function. However, the precise nature of dopaminergic control over SSRT remains unclear. This study examined region- and receptor-specific modulation of SSRT in the rat using direct infusions of the dopamine D1 receptor (DRD1) antagonist SCH 23390 or dopamine D2 receptor (DRD2) antagonist sulpiride into the dorsomedial striatum (DMStr) or nucleus accumbens core (NAcbC). DRD1 and DRD2 antagonists had contrasting effects on SSRT that were specific to the DMStr. SCH 23390 decreased SSRT with little effect on the go response. Conversely, sulpiride increased SSRT but also increased go-trial reaction time and reduced trial completion at the highest doses. These results suggest that DRD1 and DRD2 function within the DMStr, but not the NAcbC, may act to balance behavioral inhibition in a manner that is independent of behavioral activation.
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“However, blocking D2 receptors in the dorsal striatum negatively affects SST performance (Eagle et al 2011).”
From Prefrontal cortex executive processes affected by stress in health and disease (2018) · cites this paper as Eagle et al 2011
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Metadata
- Authors
- Eagle, D. M., Wong, J. C. K., Allan, M. E., Mar, A. C., Theobald, D. E., & Robbins, T. W.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Eagle, Dawn M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-05-18
- Volume
- 31
- Issue
- 20
- Pages
- 7349-7356
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3173842
- OpenAlex
- W2097947691
- Cited by
- 145
- References
- 54
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 15 · 2020: 9 · 2019: 7 · 2018: 9 · 2017: 9 · 2016: 13 · 2015: 11 · 2014: 15 · 2013: 22 · 2012: 14
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (089589/Z/09/Z, 089589, 093875)
- University of Cambridge
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine D1 receptor, dopamine D2 receptor, dorsomedial striatum, nucleus accumbens core, behavioral inhibition, stop-signal task, stop-signal reaction time, SCH 23390, sulpiride, attention deficit hyperactivity disorder
- MeSH terms
- Animals, Behavior, Animal, Benzazepines, Corpus Striatum, Inhibition, Psychological, Male, Nucleus Accumbens, Psychomotor Performance, Reaction Time, Sulpiride, Receptors, Dopamine D1, Receptors, Dopamine D2, Rats, Dopamine D2 Receptor Antagonists
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