Primate models of movement disorders of basal ganglia origin

DeLong, Mahlon R.

doi:10.1016/0166-2236(90)90110-v

Cited by 3,824Deep Brain Stimulation and Movement DisordersMotor Control and AdaptationParkinson's Disease Mechanisms and Treatments

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Primate models of movement disorders of basal ganglia origin

DeLong, Mahlon R.·1990·Trends in Neurosciences

DOI 10.1016/0166-2236(90)90110-v

Open this paper in CoChat — free account

Abstract

Movement disorders associated with basal ganglia dysfunction comprise a spectrum of abnormalities that range from the hypokinetic disorders (of which Parkinson's disease is the best-known example) at one extreme to the hyperkinetic disorders (exemplified by Huntington's disease and hemiballismus) at the other. Both extremes of this movement disorder spectrum can be accounted for by postulating specific disturbances within the basal ganglia-thalamocortical 'motor' circuit. In this paper, Mahlon DeLong describes the changes in neuronal activity in the motor circuit in animal models of hypo- and hyperkinetic disorders.

Integrity signals

Registry

Crossref · 10.1016/0166-2236(90)90110-v

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Information conducted in the meso-ventromedial system influences the meso-ventrolateral striatal dopamine system, which in turn influences the meso-dorsal striatal dopamine system via laterally diverging projections to the ventral midbrain.
“Thus, the information conducted in the meso-ventromedial system influences the meso-ventrolateral striatal dopamine system, which in turn influences the meso-dorsal striatal dopamine system (Alexander et al., 1986; DeLong, 1990) via laterally diverging projections to the ventral midbrain as shown in Figure 13.”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as DeLong, 1990

Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527
Self-citation
The functional anatomy of basal ganglia disorders
Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353
Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease
Kish, S. J., Shannak, K. S., & Hornykiewicz, O. (1988) · New England Journal of Medicine · doi:10.1056/nejm198804073181402 · Cited by 1,945
Chemical Neuroanatomy
Emson, P. C., Heffher, R. R., & Pearson, J. (1984) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198409000-00010 · Cited by 1,651
Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey
Langston, J. W., Forno, L. S., Rebert, C. S., & Irwin, I. (1984) · Brain Research · doi:10.1016/0006-8993(84)90777-7 · Cited by 922
A PHYSIOLOGICAL MECHANISM OF BRADYKINESIA
Hallett, M., & Khoshbin, S. (1980) · Brain · doi:10.1093/brain/103.2.301 · Cited by 632
DISTURBANCE OF SEQUENTIAL MOVEMENTS IN PATIENTS WITH PARKINSON'S DISEASE
Benecke, R., Rothwell, J. C., Dick, J., Day, B. L., & MARSDEN, C. D. (1987) · Brain · doi:10.1093/brain/110.2.361 · Cited by 514
PERFORMANCE OF SIMULTANEOUS MOVEMENTS IN PATIENTS WITH PARKINSON'S DISEASE
Benecke, R., Rothwell, J. C., Dick, J., Day, B. L., & MARSDEN, C. D. (1986) · Brain · doi:10.1093/brain/109.4.739 · Cited by 383
Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys
Forno, L. S., Langston, J. W., DeLanney, L. E., Irwin, I., & Ricaurte, G. A. (1986) · Annals of Neurology · doi:10.1002/ana.410200403 · Cited by 351
Abnormal influences of passive limb movement on the activity of globus pallidus neurons in parkinsonian monkeys
Filion, M., Tremblay, L., & Bédard, P. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)90924-9 · Cited by 337
Neurons of the subthalamic nucleus in primates display glutamate but not GABA immunoreactivity
Smith, Y., & Parent, A. (1988) · Brain Research · doi:10.1016/0006-8993(88)90177-1 · Cited by 336
Hemiparkinsonism in monkeys after unilateral internal carotid artery artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Bankiewicz, K. S., Oldfield, E. H., Chiueh, C. C., Doppman, J. L., Jacobowitz, D. M., & Kopin, I. J. (1986) · Life Sciences · doi:10.1016/0024-3205(86)90431-5 · Cited by 308
Scaling of the size of the first agonist EMG burst during rapid wrist movements in patients with Parkinson's disease.
Berardelli, A., Dick, J., Rothwell, J. C., Day, B. L., & MARSDEN, C. D. (1986) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.49.11.1273 · Cited by 301
Analysis of choreoid hyperkinesia in the rhesus monkey. Surgical and pharmacological analysis of hyperkinesia resulting from lesions in the subthalamic nucleus ol luys
Carpenter, M. B., Whittier, J. R., & Mettler, F. A. (1950) · The Journal of Comparative Neurology · doi:10.1002/cne.900920303 · Cited by 297
Striatal and nigral neuron subpopulations in rigid Huntington's disease: Implications for the functional anatomy of chorea and rigidity‐akinesia
Albin, R. L., Reiner, A. J., Anderson, K. D., Penney, J. B., & Young, A. B. (1990) · Annals of Neurology · doi:10.1002/ana.410270403 · Cited by 292
Intracellular study of rat substantia nigra pars reticulata neurons in an in vitro slice preparation: electrical membrane properties and response characteristics to subthalamic stimulation
Nakanishi, H., Kita, H., & Kitai, S. T. (1987) · Brain Research · doi:10.1016/0006-8993(87)91525-3 · Cited by 243
Studies on the subthalamus of the rhesus monkey. II. Hyperkinesia and other physiologic effects of subthalamic lesions, with special reference to the subthalamic nucleus of Luys
Whittier, J. R., & Mettler, F. A. (1949) · The Journal of Comparative Neurology · doi:10.1002/cne.900900304 · Cited by 217
Ballistic flexion movements of the human thumb.
Hallett, M., & MARSDEN, C. D. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012913 · Cited by 209
CONTROL OF TWO SIMULTANEOUS VOLUNTARY MOTOR ACTS IN NORMALS AND IN PARKINSONISM
Schwab, R. S. (1954) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1954.02330050061010 · Cited by 191
Parkinsonian Symptomatology An Anatomical and Physiological Analysisaa
MILLER, W. C., & DeLong, M. R. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb32998.x · Cited by 170
Self-citation
Sites of the neurotoxic action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the macaque monkey include the ventral tegmental area and the locus coeruleus
Mitchell, I., Cross, A. J., Sambrook, M. A., & Crossman, A. R. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90424-0 · Cited by 157
Simple and complex movements off and on treatment in patients with Parkinson's disease.
Benecke, R., Rothwell, J. C., Dick, J., Day, B. L., & MARSDEN, C. D. (1987) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.50.3.296 · Cited by 148
Experimental hemiballism in the monkey produced by unilateral kainic acid lesion in corpus Luysii
Hammond, C., Féger, J., Bioulac, B. H., et al. (1979) · Brain Research · doi:10.1016/0006-8993(79)91066-7 · Cited by 125
Regional brain uptake of 2-deoxyglucose in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)—induced parkinsonism in the macaque monkey
Crossman, A. R., Mitchell, I. J., & Sambrook, M. A. (1985) · Neuropharmacology · doi:10.1016/0028-3908(85)90070-x · Cited by 121
Impaired sensorimotor integration in parkinsonism and dyskinesia: a role for corollary discharges?
Moore, A. P. (1987) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.50.5.544 · Cited by 88
Functions of the Basal Ganglia CIBA Foundation Symposium 107
Stern, G. (1985) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.48.6.610 · Cited by 75
Neural mechanisms mediating 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the monkey: Relative contributions of the striatopallidal and striatonigral pathways as suggested by 2-deoxyglucose uptake
Mitchell, I., Cross, A. J., Sambrook, M. A., & Crossman, A. R. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90013-3 · Cited by 72
Deficits in behavioral initiation and execution processes in monkeys with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism
Schultz, W., Studer, A., JONSSON, G., et al. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90204-6 · Cited by 69
Changes in the local cerebral metabolic rate for glucose in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) primate model of Parkinson's disease
Schwartzman, R. J., & Alexander, G. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90957-6 · Cited by 60
Changes in local cerebral glucose utilization associated with Parkinson's syndrome induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) in the primate
Porrino, L. J., Burns, R. S., Crane, A. M., Palombo, E., Kopin, I. J., & Sokoloff, L. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90014-2 · Cited by 55
Cerebral metabolism of Parkinsonian primates 21 days after MPTP
Schwartzman, R. J., Alexander, G. M., Ferraro, T. N., et al. (1988) · Experimental Neurology · doi:10.1016/0014-4886(88)90224-5 · Cited by 40
Huntington's Chorea
Fahn, S. (1984) · Neurology · doi:10.1212/wnl.34.2.268 · Cited by 10

Flagged first, then by citations

Research works printed but not linked: 7

Alexander, G. E., Crutcher, M. D. and DeLong, M. R. Prog. Brain Res. (in press)
Burns, 1983, 80, 4546
Filion, 1985, Soc. Neurosci. Abstr., 11, 1160
Draper, 1964, Bull. Johns Hopkins Hosp., 115, 465
Langston, 1984, Neurology, 34, 268
Hamada, 1988, Soc. Neurosci. Abstr., 14, 719
Reiner, 1988, 85, 5733

Sorted by citations

Frontal-subcortical circuits and human behavior
Cummings, J. L. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540080076020 · Cited by 2,262
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
Kravitz, A. V., Freeze, B. S., Parker, P. R. L., Kay, K., Thwin, M. T., Deisseroth, K., & Kreitzer, A. C. (2010) · Nature · doi:10.1038/nature09159 · Cited by 1,885
Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477
Functional significance of the cortico-subthalamo-pallidal “hyperdirect” pathway
Nambu, A., Tokuno, H., & Takada, M. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00027-5 · Cited by 1,371
The Basal Ganglia and Adaptive Motor Control
Graybiel, A. M., Aosaki, T., Flaherty, A. W., & Kimura, M. (1994) · Science · doi:10.1126/science.8091209 · Cited by 1,324
Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease
Redgrave, P., Rodriguez, M., Smith, Y., Rodriguez-Oroz, M. C., Lehericy, S., Bergman, H., Agid, Y., DeLong, M. R., & Obeso, J. A. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2915 · Cited by 1,134
Functional recovery in parkinsonian monkeys treated with GDNF
Gash, D. M., Zhang, Z., Ovadia, A., Cass, W. A., Yi, A., Simmerman, L., Russell, D., Martin, D., Lapchak, P. A., Collins, F., et al. (1996) · Nature · doi:10.1038/380252a0 · Cited by 955
Corticostriatal connectivity and its role in disease
Shepherd, G. M. G. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3469 · Cited by 824
Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy
Obeso, J. A., Stamelou, M., Goetz, C. G., Poewe, W., Lang, A. E., Weintraub, D., Burn, D., Halliday, G. M., Bezard, E., Przedborski, S., et al. (2017) · Movement Disorders · doi:10.1002/mds.27115 · Cited by 859
“If dopamine is deficient, this may shift the balance of activity in direct and indirect pathways toward inhibition, causing a poverty of movement.(134) In addition, it may change the way populations of neurones interact in the overall cortexbasal ganglia-thalamus-cortex loops.”
Self-citation
Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder
Saxena, S., & Rauch, S. L. (2000) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70181-7 · Cited by 840
Building neural representations of habits.
Jog, M. S., Kubota, Y., Connolly, C. I., Hillegaart, V., & Graybiel, A. M. (1999) · Science · doi:10.1126/science.286.5445.1745 · Cited by 834
Neuroimaging and frontal–subcortical circuitry in obsessive–compulsive disorder
Saxena, S., Brody, A. L., Schwartz, J. M., & Baxter, L. R. (1998) · British Journal of Psychiatry · doi:10.1192/s0007125000297870 · Cited by 831
Hold your horses: a dynamic computational role for the subthalamic nucleus in decision making
Frank, M. J. (2006) · Neural Networks · doi:10.1016/j.neunet.2006.03.006 · Cited by 706
Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates
Bergman, H., Feingold, A., Nini, A., Raz, A., Slovin, H., Abeles, M., & Vaadia, E. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01151-x · Cited by 630
The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum
Joel, D., & Weiner, I. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00575-8 · Cited by 614
A fronto–striato–subthalamic–pallidal network for goal-directed and habitual inhibition
Jahanshahi, M., Obeso, I., Rothwell, J. C., & Obeso, J. A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4038 · Cited by 521
Mechanisms of deep brain stimulation
Herrington, T. M., Cheng, J. J., & Eskandar, E. N. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00281.2015 · Cited by 551
The cerebral oscillatory network of parkinsonian resting tremor
Timmermann, L., Gross, J., Dirks, M., Volkmann, J., Freund, H.-J., & Schnitzler, A. (2003) · Brain · doi:10.1093/brain/awg022 · Cited by 544
Physiology and pharmacology of striatal neurons
Kreitzer, A. C. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135422 · Cited by 530
History, Applications, and Mechanisms of Deep Brain Stimulation
Miocinovic, S., Somayajula, S., Chitnis, S., & Vitek, J. L. (2013) · JAMA Neurology · doi:10.1001/2013.jamaneurol.45 · Cited by 496
Differential Innervation of Direct- and Indirect-Pathway Striatal Projection Neurons
Wall, N. R., De La Parra, M., Callaway, E. M., & Kreitzer, A. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.014 · Cited by 489
Transient stimulation of distinct subpopulations of striatal neurons mimics changes in action value
Tai, L.-H., Lee, A. M., Benavidez, N., Bonci, A., & Wilbrecht, L. (2012) · Nature Neuroscience · doi:10.1038/nn.3188 · Cited by 399
FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains
Lobo, M. K., Karsten, S. L., Gray, M., Geschwind, D. H., & Yang, X. W. (2006) · Nature Neuroscience · doi:10.1038/nn1654 · Cited by 411
Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis
Altamura, S., & Muckenthaler, M. U. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1010 · Cited by 369
The neural bases of obsessive-compulsive disorder in children and adults
Maia, T. V., Cooney, R. E., & Peterson, B. S. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000606 · Cited by 362
Basal ganglia dysfunction in Tourette’s syndrome: a new hypothesis
Mink, J. W. (2001) · Pediatric Neurology · doi:10.1016/s0887-8994(01)00262-4 · Cited by 357
Mechanisms of action of deep brain stimulation (DBS)
Montgomery, E. B., & Gale, J. T. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.06.003 · Cited by 344
Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson's Disease
Fuentes, R., Petersson, P., Siesser, W. B., Caron, M. G., & Nicolelis, M. A. L. (2009) · Science · doi:10.1126/science.1164901 · Cited by 298
Forced, not voluntary, exercise improves motor function in Parkinson's disease patients
Ridgel, A. L., Vitek, J. L., & Alberts, J. L. (2009) · Neurorehabilitation and neural repair · doi:10.1177/1545968308328726 · Cited by 284
The anatomical relationships of the prefrontal cortex with limbic structures and the basal ganglia
Groenewegen, H. J., Wright, C. I., & Uylings, H. B. M. (1997) · Journal of Psychopharmacology · doi:10.1177/026988119701100202 · Cited by 268
Prototypic and arkypallidal neurons in the dopamine-intact external globus pallidus
Abdi, A., Mallet, N., Mohamed, F. Y., Sharott, A., Dodson, P. D., Nakamura, K. C., Suri, S., Avery, S. V., Larvin, J. T., Garas, F. N., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4662-14.2015 · Cited by 247
Changes in human motor cortex excitability induced by dopaminergic and anti-dopaminergic drugs
Ziemann, U., Tergau, F., Bruns, D., Baudewig, J., & Paulus, W. (1997) · Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control · doi:10.1016/s0924-980x(97)00050-7 · Cited by 242
Transcranial magnetic brain stimulation: Therapeutic promises and scientific gaps
Wassermann, E. M., & Zimmermann, T. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.09.003 · Cited by 243
Striatal mechanisms underlying movement, reinforcement, and punishment
Kravitz, A. V., & Kreitzer, A. C. (2012) · Physiology · doi:10.1152/physiol.00004.2012 · Cited by 224
A history of deep brain stimulation: Technological innovation and the role of clinical assessment tools
Gardner, J. (2013) · Social Studies of Science · doi:10.1177/0306312713483678 · Cited by 243
Organization and evolution of the avian forebrain
Reiner, A., Yamamoto, K., & Karten, H. J. (2005) · The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology · doi:10.1002/ar.a.20253 · Cited by 222
Birdbrains could teach basal ganglia research a new song
DOUPE, A., PERKEL, D., REINER, A., & STERN, E. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.05.005 · Cited by 219
Genetically distinct parallel pathways in the entopeduncular nucleus for limbic and sensorimotor output of the basal ganglia
Wallace, M. L., Saunders, A., Huang, K. W., Philson, A. C., Goldman, M., Macosko, E. Z., McCarroll, S. A., & Sabatini, B. L. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.017 · Cited by 205
The serotonergic system in Parkinson's disease
Huot, P., Fox, S. H., & Brotchie, J. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.004 · Cited by 195
It Is Not About the Bike, It Is About the Pedaling: Forced Exercise and Parkinson's Disease
Alberts, J. L., Linder, S. M., Penko, A. L., Lowe, M. J., & Phillips, M. (2011) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31822cc71a · Cited by 192
The evolutionary origin of the vertebrate basal ganglia and its role in action selection
Grillner, S., Robertson, B., & Stephenson‐Jones, M. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.246660 · Cited by 184
Dopamine Gene Therapy for Parkinson’s Disease in a Nonhuman Primate Without Associated Dyskinesia
Jarraya, B., Boulet, S., Scott Ralph, G., Jan, C., Bonvento, G., Azzouz, M., Miskin, J. E., Shin, M., Delzescaux, T., Drouot, X., et al. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000130 · Cited by 186
Defective cortical drive to muscle in Parkinson's disease and its improvement with levodopa
Salenius, S., Avikainen, S., Kaakkola, S., Hari, R., & Brown, P. (2002) · Brain · doi:10.1093/brain/awf042 · Cited by 180
Connecting circuits for supraspinal control of locomotion
Ferreira-Pinto, M. J., Ruder, L., Capelli, P., & Arber, S. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.015 · Cited by 140
Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics
Ting, J. T., & Feng, G. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.04.010 · Cited by 143
Single-cell analysis reveals a close relationship between differentiating dopamine and subthalamic nucleus neuronal lineages
Kee, N., Volakakis, N., Kirkeby, A., Dahl, L., Storvall, H., Nolbrant, S., Lahti, L., Björklund, Å. K., Gillberg, L., Joodmardi, E., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2016.10.003 · Cited by 149
New roles for the external globus pallidus in basal ganglia circuits and behavior
Gittis, A. H., Berke, J. D., Bevan, M. D., Chan, C. S., Mallet, N., Morrow, M. M., & Schmidt, R. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3252-14.2014 · Cited by 136
Contrasting roles for dopamine D1 and D2 receptor subtypes in the dorsomedial striatum but not the nucleus accumbens core during behavioral inhibition in the stop-signal task in rats
Eagle, D. M., Wong, J. C. K., Allan, M. E., Mar, A. C., Theobald, D. E., & Robbins, T. W. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6182-10.2011 · Cited by 145
Changing views of basal ganglia circuits and circuit disorders
DeLong, M., & Wichmann, T. (2010) · Clinical EEG and Neuroscience · doi:10.1177/155005941004100204 · Cited by 128
Self-citation
Cannabidiol as a Therapeutic Target: Evidence of its Neuroprotective and Neuromodulatory Function in Parkinson’s Disease
Patricio, F., Morales-Andrade, A. A., Patricio-Martínez, A., & Limón, I. D. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.595635 · Cited by 129
Current applications and limitations of surgical treatments for movement disorders
Krack, P., Martinez‐Fernandez, R., del Alamo, M., & Obeso, J. A. (2017) · Movement Disorders · doi:10.1002/mds.26890 · Cited by 122
Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration
Higley, M. J., Soler-Llavina, G. J., & Sabatini, B. L. (2009) · Nature Neuroscience · doi:10.1038/nn.2368 · Cited by 110
Striatal parvalbuminergic neurons are lost in Huntington's disease: implications for dystonia
Reiner, A., Shelby, E., Wang, H., DeMarch, Z., Deng, Y., Guley, N. H., Hogg, V., Roxburgh, R., Tippett, L. J., Waldvogel, H. J., et al. (2013) · Movement Disorders · doi:10.1002/mds.25624 · Cited by 102
Altered Cortico–Striatal Functional Connectivity During Resting State in Obsessive–Compulsive Disorder
Calzà, J., Gürsel, D. A., Schmitz-Koep, B., Bremer, B., Reinholz, L., Berberich, G., & Koch, K. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00319 · Cited by 99
“In particular, different animal studies report a direct structural connection between the external and the internal globus pallidus, suggesting that the role of the GPe is more central and complex as stated by the traditional CSTC model, and it probably has a role in controlling the function of the GPi/SNr (19, 25, 26…”
BackgroundInfluential
Paradoxical Motor Recovery From a First Stroke After Induction of a Second Stroke: Reopening a Postischemic Sensitive Period
Zeiler, S. R., Hubbard, R., Gibson, E. M., Zheng, T., Ng, K., O’Brien, R., & Krakauer, J. W. (2016) · Neurorehabilitation and Neural Repair · doi:10.1177/1545968315624783 · Cited by 97
Striatal structure and function in mood disorders: a comprehensive review
Marchand, W. R., & Yurgelun‐Todd, D. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00874.x · Cited by 91
Basal Ganglia
Gerfen, C. R. (2004) · The Rat Nervous System · doi:10.1016/b978-012547638-6/50019-5 · Cited by 85
Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice
Ade, K. K., Wan, Y., Hamann, H. C., O’Hare, J. K., Guo, W., Quian, A., Kumar, S., Bhagat, S., Rodriguiz, R. M., Wetsel, W. C., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.04.023 · Cited by 84
A Connectomic Analysis of the Human Basal Ganglia Network
Cacciola, A., Calamuneri, A., Milardi, D., Mormina, E., Chillemi, G., Marino, S., Naro, A., Rizzo, G., Anastasi, G., & Quartarone, A. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00085 · Cited by 81
Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson’s disease
Yeo, S., Choe, I.-H., van den Noort, M., Bosch, P., Jahng, G.-H., Rosen, B., Kim, S.-H., & Lim, S. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-336 · Cited by 64
Persistent effects of obesity: A neuroplasticity hypothesis
Matikainen‐Ankney, B. A., & Kravitz, A. V. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13665 · Cited by 56
Monoamine abnormalities in the SAPAP3 knockout model of obsessive-compulsive disorder-related behaviour
Wood, J., LaPalombara, Z., & Ahmari, S. E. (2018) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2017.0023 · Cited by 41
Changes in brain functional activation during resting and locomotor states after unilateral nigrostriatal damage in rats
Yang, J., Sadler, T. R., Givrad, T. K., Maarek, J.-M. I., & Holschneider, D. P. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.010 · Cited by 41
Is there a role for ghrelin in central dopaminergic systems? Focus on nigrostriatal and mesocorticolimbic pathways
Stievenard, A., Méquinion, M., Andrews, Z. B., Destée, A., Chartier-Harlin, M.-C., Viltart, O., & Vanbesien-Mailliot, C. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.021 · Cited by 39
Corticostriatal foundations of habits
Seger, C. A. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.01.006 · Cited by 38
Between the primate and 'reptilian' brain: rodent models demonstrate the role of corticostriatal circuits in decision making
Lee, A. M., Tai, L.-H., Zador, A., & Wilbrecht, L. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.042 · Cited by 37
Ceftriaxone Reverses Deficits of Behavior and Neurogenesis in an MPTP-Induced Rat Model of Parkinson’s Disease Dementia
Hsieh, M.-H., Meng, W.-Y., Liao, W.-C., Weng, J.-C., Li, H.-H., Su, H.-L., Lin, C.-L., Hung, C.-S., & Ho, Y.-J. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.05.015 · Cited by 35
Functional segregation and integration within the human subthalamic nucleus from a micro- and meso-level perspective
van Wijk, B. C. M., Alkemade, A., & Forstmann, B. U. (2020) · Cortex · doi:10.1016/j.cortex.2020.07.004 · Cited by 25
Contralateral voluntary hand movement inhibits human parkinsonian tremor and variably influences essential tremor
Tamás, G., Pálvölgyi, L., Takáts, A., Szirmai, I., & Kamondi, A. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.12.092 · Cited by 10
On the motion of spikes: turbulent-like neuronal activity in the human Basal Ganglia
Andres, D. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00429 · Cited by 4

Authors: DeLong, M. R.
Affiliations: Johns Hopkins University (US)
Corresponding author: DeLong, Mahlon R.
ORCID: DeLong, Mahlon R.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 1990-07
Volume: 13
Issue: 7
Pages: 281-285
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/0166-2236(90)90110-v
OpenAlex: W1982827121
Cited by: 3,824
References: 32
Citations by year: 2026: 76 · 2025: 92 · 2024: 86 · 2023: 111 · 2022: 95 · 2021: 123 · 2020: 158 · 2019: 126 · 2018: 117 · 2017: 153 · 2016: 137 · 2015: 130 · 2014: 117 · 2013: 121 · 2012: 135
FWCI: 5.71
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ns015417-15)
National Institute of Neurological Disorders and Stroke (NS15417)
Topics: Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: basal ganglia, movement disorders, Parkinson's disease, Huntington's disease, hemiballismus, basal ganglia-thalamocortical circuit, hyperkinetic disorder, animal models, neuronal activity
MeSH terms: Animals, Basal Ganglia Diseases, Disease Models, Animal, Models, Neurological, Movement Disorders, Parkinson Disease, Secondary, Primates, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Primate models of movement disorders of basal ganglia origin

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks