Central Cardiovascular Circuits Contribute to the Neurovascular Dysfunction in Angiotensin II Hypertension

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The Science of Stroke: Mechanisms in Search of Treatments

Moskowitz, M. A., Lo, E. H., & Iadecola, C. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.002 · Cited by 1,930

Gender differences in the regulation of blood pressure

Reckelhoff, J. F. (2001) · Hypertension · doi:10.1161/01.hyp.37.5.1199 · Cited by 1,268

Silent Brain Infarcts and White Matter Lesions Increase Stroke Risk in the General Population

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White Matter Lesions in an Unselected Cohort of the Elderly: Molecular Pathology Suggests Origin From Chronic Hypoperfusion Injury

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Hypertension and Cerebrovascular Dysfunction

Iadecola, C., & Davisson, R. L. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.010 · Cited by 557

The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia

Iadecola, C. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0718-6 · Cited by 557

Oxidative Stress and Hypertension

Harrison, D. G., & Góngora, M. C. (2009) · Medical Clinics of North America · doi:10.1016/j.mcna.2009.02.015 · Cited by 455

Optimization of differential immunogold-silver and peroxidase labeling with maintenance of ultrastructure in brain sections before plastic embedding

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Hypertension Caused by Angiotensin II Infusion Involves Increased Superoxide Production in the Central Nervous System

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Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

Kisler, K., Nelson, A. R., Montagne, A., & Zlokovic, B. V. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.48 · Cited by 1,243

Neurovascular and Cognitive Dysfunction in Hypertension

Iadecola, C., & Gottesman, R. F. (2019) · Circulation Research · doi:10.1161/circresaha.118.313260 · Cited by 528

Defining the relationship between hypertension, cognitive decline, and dementia: a review

Walker, K. A., Power, M. C., & Gottesman, R. F. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0724-3 · Cited by 394

Hypertension: A Harbinger of Stroke and Dementia

Faraco, G., & Iadecola, C. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01063 · Cited by 367

Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension

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Animal Models of Hypertension: A Scientific Statement From the American Heart Association

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Reactive Oxygen Species, Vascular Noxs, and Hypertension: Focus on Translational and Clinical Research

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Evidence of neurodegeneration in obstructive sleep apnea: Relationship between obstructive sleep apnea and cognitive dysfunction in the elderly

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Hypertension enhances A β -induced neurovascular dysfunction, promotes β -secretase activity, and leads to amyloidogenic processing of APP

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Hypertension, Neurodegeneration, and Cognitive Decline

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The interplay between Angiotensin II, TLR4 and hypertension

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TLR4 participates in sympathetic hyperactivity Post-MI in the PVN by regulating NF-κB pathway and ROS production

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Compromised blood–brain barrier permeability: novel mechanism by which circulating angiotensin II signals to sympathoexcitatory centres during hypertension

Biancardi, V. C., & Stern, J. E. (2015) · The Journal of Physiology · doi:10.1113/jp271584 · Cited by 116

Cross talk between AT1receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus

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Neurovascular Regulation in the Ischemic Brain

Jackman, K. A., & Iadecola, C. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5669 · Cited by 117

Death by a Thousand Cuts in Alzheimer’s Disease: Hypoxia—The Prodrome

Daulatzai, M. A. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9379-2 · Cited by 114

Hypertension, dietary salt and cognitive impairment

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Rostral Ventrolateral Medulla and Hypertension

Guyenet, P. G., Stornetta, R. L., Holloway, B. B., Souza, G. M. P. R., & Abbott, S. B. G. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.10921 · Cited by 97

Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer’s disease

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Reducing T imp3 or vitronectin ameliorates disease manifestations in CADASIL mice

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Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K + channel function

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Vasculo-Neuronal Coupling and Neurovascular Coupling at the Neurovascular Unit: Impact of Hypertension

Presa, J., Saravia, F., Bagi, Z. A., & Filosa, J. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.584135 · Cited by 97

Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment

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Rodent models of hypertension

Jama, H. A., Muralitharan, R. R., Xu, C., O’Donnell, J. A., Bertagnolli, M., Broughton, B. R. S., Head, G. A., & Marques, F. Z. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15650 · Cited by 85

Prevalence of mild cognitive impairment in patients with hypertension: a systematic review and meta-analysis

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Angiotensin type 2 receptors: blood pressure regulation and end organ damage

Sumners, C., de Kloet, A. D., Krause, E. G., Unger, T., & Steckelings, U. M. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.01.004 · Cited by 79

Effects of angiotensin II on the cerebral circulation: role of oxidative stress

Silva, T. M. D., & Faraci, F. M. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2012.00484 · Cited by 77

A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction

Hay, M., Polt, R. L., Heien, M. L., Vanderah, T. W., Largent‐Milnes, T. M., Rodgers, K. E., Falk, T., Bartlett, M. J., Doyle, K. P., & Konhilas, J. P. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.254854 · Cited by 71

Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease

Csiszár, A., Tucsek, Z., Tóth, P., Sosnowska, D., Gautam, T., Koller, Á., Deák, F., Sonntag, W. E., & Ungvari, Z. I. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00288.2013 · Cited by 72

Water Deprivation Induces Neurovascular and Cognitive Dysfunction through Vasopressin-Induced Oxidative Stress

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Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics

Capone, C., Dabertrand, F., Baron‐Menguy, C., Chalaris, A., Ghezali, L., Domenga, V., Schmidt, S., Huneau, C., Rose‐John, S., Nelson, M. T., et al. (2016) · eLife · doi:10.7554/elife.17536 · Cited by 72

Chronic perfusion of angiotensin II causes cognitive dysfunctions and anxiety in mice

Duchemin, S., Bélanger, É., Wu, R., Ferland, G., & Girouard, H. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.10.005 · Cited by 68

The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes

Hariharan, A., Weir, N., Robertson, C., He, L., Betsholtz, C., & Longden, T. A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.601324 · Cited by 64

Neurovascular signaling in the brain and the pathological consequences of hypertension

Dunn, K. M. J., & Nelson, M. T. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00364.2013 · Cited by 61

Circulating Endothelin-1 Alters Critical Mechanisms Regulating Cerebral Microcirculation

Faraco, G., Moraga, A., Moore, J. M. R., Anrather, J., Pickel, V. M., & Iadecola, C. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01761 · Cited by 61

Multimodal Imaging in Rats Reveals Impaired Neurovascular Coupling in Sustained Hypertension

Calcinaghi, N., Wyss, M. T., Jolivet, R., Singh, A., Keller, A. L., Winnik, S. H., Fritschy, J., Buck, A., Matter, C. M., & Weber, B. (2013) · Stroke · doi:10.1161/strokeaha.111.000185 · Cited by 59

Angiotensin II slow-pressor hypertension enhances NMDA currents and NOX2-dependent superoxide production in hypothalamic paraventricular neurons

Wang, G., Coleman, C. G., Chan, J., Faraco, G., Marques-Lopes, J., Milner, T. A., Guruju, M. R., Anrather, J., Davisson, R. L., Iadecola, C., et al. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00367.2012 · Cited by 58

Vascular Contributions to Cognitive Impairment and Dementia

Madigan, J. B., Wilcock, D. M., & Hainsworth, A. H. (2016) · Stroke · doi:10.1161/strokeaha.116.012066 · Cited by 56

Brain and Circulating Levels of Aβ1–40 Differentially Contribute to Vasomotor Dysfunction in the Mouse Brain

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Brain Vasculature and Cognition

Fouda, A. Y., Fagan, S. C., & Ergul, A. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311906 · Cited by 53

Increases in hypertension-induced cerebral microhemorrhages exacerbate gait dysfunction in a mouse model of Alzheimer’s disease

Nyúl‐Tóth, Á., Tarantini, S., Kiss, T., Tóth, P., Galván, V., Tarantini, A., Yabluchanskiy, A., Csiszár, A., & Ungvari, Z. I. (2020) · GeroScience · doi:10.1007/s11357-020-00256-3 · Cited by 52

The renin-angiotensin system and the retinal neurovascular unit: A role in vascular regulation and disease

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NMDA Receptor Plasticity in the Hypothalamic Paraventricular Nucleus Contributes to the Elevated Blood Pressure Produced by Angiotensin II

Glass, M. J., Wang, G., Coleman, C. G., Chan, J., Ogorodnik, E., Kempen, T. A. V., Milner, T. A., Butler, S. D., Young, C. N., Davisson, R. L., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2301-14.2015 · Cited by 45

Membrane Trafficking of NADPH Oxidase p47phoxin Paraventricular Hypothalamic Neurons Parallels Local Free Radical Production in Angiotensin II Slow-Pressor Hypertension

Coleman, C. G., Wang, G., Faraco, G., Marques-Lopes, J., Waters, E. M., Milner, T. A., Iadecola, C., & Pickel, V. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3061-12.2013 · Cited by 43

Functional Neural–Bone Marrow Pathways

Zubcevic, J. A., Santisteban, M. M., Pitts, T. E., Baekey, D. M., Pérez, P. D., Bolser, D. C., Febo, M., & Raizada, M. K. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.02440 · Cited by 42

Accelerated Ovarian Failure as a Unique Model to Study Peri-Menopause Influence on Alzheimer’s Disease

Marongiu, R. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00242 · Cited by 45

Angiotensin and Neurovascular Coupling: Beyond Hypertension

Bloch, S., Obari, D., & Girouard, H. (2015) · Microcirculation · doi:10.1111/micc.12193 · Cited by 40

Potential Clinical Application of Recently Discovered Brain Mechanisms Involved in Hypertension

Hirooka, Y., Kishi, T., Ito, K., & Sunagawa, K. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.00801 · Cited by 36

Vasopressin Hypersecretion-Associated Brain Edema Formation in Ischemic Stroke: Underlying Mechanisms

Jia, S., Liu, X., Wang, S. C., & Wang, Y. (2016) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2016.02.002 · Cited by 36

High salt induced hypertension leads to cognitive defect

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Tumor Necrosis Factor α Receptor Type 1 Activation in the Hypothalamic Paraventricular Nucleus Contributes to Glutamate Signaling and Angiotensin II-Dependent Hypertension

Woods, C., Marques-Lopes, J., Contoreggi, N. H., Milner, T. A., Pickel, V. M., Wang, G., & Glass, M. J. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2360-19.2020 · Cited by 34

Melatonin receptor and KATP channel modulation in experimental vascular dementia

Singh, P. K., Gupta, S., & Sharma, B. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.02.009 · Cited by 33

Cerebrovascular Disease: Consequences of Obesity-Induced Endothelial Dysfunction

Letra, L., & Sena, C. M. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-63260-5_7 · Cited by 33

Perivascular macrophages in the CNS : From health to neurovascular diseases

Li, Z., Guo, Y., Zhai, X., Zhang, Y., Chen, W., Zhu, Z., Xuan, W., & Li, P. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13954 · Cited by 36

Long-Term Blood Pressure Variability Across the Clinical and Biomarker Spectrum of Alzheimer’s Disease

Sible, I. J., Initiative, A. D. N., & Nation, D. A. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200221 · Cited by 31

Mineralocorticoid and AT1 receptors in the paraventricular nucleus contribute to sympathetic hyperactivity and cardiac dysfunction in rats post myocardial infarct

Huang, B. S., Chen, A., Ahmad, M., Wang, H., & Leenen, F. H. H. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.276584 · Cited by 28

Endothelin and Diabetic Complications: a Brain-Centric View

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Improving Cerebrovascular Function to Increase Neuronal Recovery in Neurodegeneration Associated to Cardiovascular Disease

Vanherle, L., Matušková, H., Don‐Doncow, N., Uhl, F. E., & Meißner, A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00053 · Cited by 25

Sex differences in NMDA GluN1 plasticity in rostral ventrolateral medulla neurons containing corticotropin-releasing factor type 1 receptor following slow-pressor angiotensin II hypertension

Kempen, T. A. V., Dodos, M., Woods, C., Marques-Lopes, J., Justice, N. J., Iadecola, C., Pickel, V. M., Glass, M. J., & Milner, T. A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.029 · Cited by 22

Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system

Chen, K., Sun, D., Qu, S., Chen, Y., Wang, J., Zhou, L., José, P. A., Yang, Y., & Zeng, C. (2019) · Clinical Science · doi:10.1042/cs20190254 · Cited by 21

Pathobiological Interactions of Local Bone Marrow Renin-Angiotensin System and Central Nervous System in Systemic Arterial Hypertension

Ciftciler, R., & Haznedaroglu, I. C. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00425 · Cited by 20

Angiotensin receptor blockade with olmesartan alleviates brain pathology in obese OLETF rats

Rodríguez‐Ortiz, C. J., Thorwald, M. A., Rodríguez, R., Mejias‐Ortega, M., Kieu, Z., Maitra, N., Hawkins, C., Valenzuela, J., Peng, M., Nishiyama, A., et al. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13738 · Cited by 13

Alterations in the subcellular distribution of NADPH oxidase p47phoxin hypothalamic paraventricular neurons following slow‐pressor angiotensin II hypertension in female mice with accelerated ovarian failure

Kempen, T. A. V., Narayan, A., Waters, E. M., Marques-Lopes, J., Iadecola, C., Glass, M. J., Pickel, V. M., & Milner, T. A. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23944 · Cited by 13

Endothelial Cells and the Cerebral Circulation

Lansdell, T. A., Chambers, L. C., & Dorrance, A. M. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210015 · Cited by 22

Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution

Schaeffer, S. M., Pacholko, A. G., Santisteban, M. M., Ahn, S. J., Racchumi, G., Wang, G., Park, L., Faraco, G., Anrather, J., & Iadecola, C. (2025) · Neuron · doi:10.1016/j.neuron.2025.10.018 · Cited by 14

Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo

Cull, J. J., Cooper, S. T. E., Alharbi, H. O., Chothani, S. P., Rackham, O. J. L., Meijles, D. N., Dash, P. R., Kerkelä, R., Ruparelia, N., Sugden, P. H., et al. (2024) · Clinical Science · doi:10.1042/cs20240496 · Cited by 11

Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

Alharbi, H. O., Hardyman, M. A., Cull, J. J., Markou, T., Cooper, S. T. E., Glennon, P. E., Fuller, S. J., Sugden, P. H., & Clerk, A. (2022) · Clinical Science · doi:10.1042/cs20220607 · Cited by 11

Interplay of Angiotensin Peptides, Vasopressin, and Insulin in the Heart: Experimental and Clinical Evidence of Altered Interactions in Obesity and Diabetes Mellitus

Szczepanska‐Sadowska, E. K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021310 · Cited by 10

Current updates on latest basic research of scientific relevance in hypertensive dementia

Mogi, M., Takami, Y., Ihara, M., Yamashita, T., Takeda, S., Shibata, S., Node, K., Kario, K., Prevention of Cognitive Impairment by Hypertension Management (PCIHM) Working Group of the Japanese Society of Hypertension, Mogi, M., et al. (2025) · Hypertension Research · doi:10.1038/s41440-025-02417-3 · Cited by 11

Rodent Models of Ovarian Failure

Marques-Lopes, J., Kempen, T. A. V., & Milner, T. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00060-9 · Cited by 9

Olmesartan combined with renal denervation reduces blood pressure in association with sympatho-inhibitory and aldosterone-reducing effects in hypertensive mice with chronic kidney disease

Nishihara, M., Takesue, K., & Hirooka, Y. (2018) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2018.1465075 · Cited by 9

Endothelium, the Blood–Brain Barrier, and Hypertension

Silva, T. M. D., Silva, R. A. P., & Faraci, F. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-25616-0_8 · Cited by 9

Border-associated macrophages: From physiology to therapeutic targets in Alzheimer's disease

Zheng, F., Dong, T., Chen, Y., Wang, L., & Peng, G. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115021 · Cited by 8

Angiotensin II Infusion Results in Both Hypertension and Increased AMPA GluA1 Signaling in Hypothalamic Paraventricular Nucleus of Male but not Female Mice

Wang, G., Woods, C., Johnson, M. A., Milner, T. A., & Glass, M. J. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2021.12.041 · Cited by 10

A Review on Garlic as a Supplement for Alzheimer’s Disease: A Mechanistic Insight into its Direct and Indirect Effects

Ghazimoradi, M. M., Pour, M. G., Ghoushi, E., Ahmadabadi, H. K., & Rafieian‐Kopaei, M. (2023) · Current Pharmaceutical Design · doi:10.2174/1381612829666230222093016 · Cited by 7

Hypertension prevents a sensory stimulation-based collateral therapeutic from protecting the cortex from impending ischemic stroke damage in a spontaneously hypersensitive rat model

Hancock, A. M., & Frostig, R. D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206291 · Cited by 6

Experimental Evidences Supporting Training-Induced Benefits in Spontaneously Hypertensive Rats

Masson, G. S., & Michelini, L. C. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4307-9_16 · Cited by 5

Angiotensin-(1-7) Receptor Mas in Hemodynamic and Thermoregulatory Dysfunction After High-Level Spinal Cord Injury in Mice: A Pilot Study

Järve, A., Todiraş, M., Kny, M., Fischer, F. I., Kraemer, J. F., Wessel, N., Plehm, R., Fielitz, J., Alenina, N. V., & Bäder, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01930 · Cited by 5

The relationship between dehydration and etiologic subtypes of major neurocognitive disorder in older patients

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Fourth European stroke science workshop

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