Gender differences in the regulation of blood pressure
Abstract
Men are at greater risk for cardiovascular and renal disease than are age-matched, premenopausal women. Recent studies using the technique of 24-hour ambulatory blood pressure monitoring have shown that blood pressure is higher in men than in women at similar ages. After menopause, however, blood pressure increases in women to levels even higher than in men. Hormone replacement therapy in most cases does not significantly reduce blood pressure in postmenopausal women, suggesting that the loss of estrogens may not be the only component involved in the higher blood pressure in women after menopause. In contrast, androgens may decrease only slightly, if at all, in postmenopausal women. In this review the possible mechanisms by which androgens may increase blood pressure are discussed. Findings in animal studies show that there is a blunting of the pressure-natriuresis relationship in male spontaneously hypertensive rats and in ovariectomized female spontaneously hypertensive rats treated chronically with testosterone. The key factor in controlling the pressure-natriuresis relationship is the renin-angiotensin system (RAS). The possibility that androgens increase blood pressure via the RAS is explored, and the possibility that the RAS also promotes oxidative stress leading to production of vasoconstrictor substances and reduction in nitric oxide availability is proposed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Post-menopausal females have higher blood pressure than males, which can be attributed to arterial stiffness.
“However, post-menopausal females have higher blood pressure than males, which can be attributed to arterial stiffness [101].”
From Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring (2021) · cites this paper as [101]
Reckelhoff reported the mean blood pressure was 6-10 mmHg higher in males than in pre-menopausal females.
“Regarding blood pressure, Reckelhoff reported the mean blood pressure was 6–10 mmHg higher in males than in pre-menopausal females.”
From Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring (2021) · cites this paper as [101]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Burt, V. L., Whelton, P., Roccella, E. J., Brown, C., Cutler, J. A., Higgins, M., Horan, M. J., & Labarthe, D. (1995) · Hypertension · doi:10.1161/01.hyp.25.3.305 · Cited by 2,998 · see citing works
Rajagopalan, S., Kurz, S. D., Münzel, T. F., Tarpey, M. M., Freeman, B. Α., Griendling, K. K., & Harrison, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118623 · Cited by 2,441 · see citing works
Valery (1995) · doi:10.1001/jama.1995.03520270033028 · Cited by 2,320 · see citing works
Hypertension : pathophysiology, diagnosis, and management
Laragh, J. H., & Brenner, B. M. (1995) · Raven Press eBooks · Cited by 1,935 · see citing works
Morrow, J. D., Hill, K. E., Burk, R. F., Nammour, T., Badr, K. F., & Roberts, L. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.23.9383 · Cited by 1,898 · see citing works
The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide
Pryor, W. A., & Squadrito, G. L. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.268.5.l699 · Cited by 1,511 · see citing works
Guyton, A., Coleman, T. G., Cowley, A. W., Scheel, K., Manning, R., & Norman, R. A. (1972) · American Journal of Medicine · doi:10.1016/0002-9343(72)90050-2 · Cited by 1,110 · see citing works
Induction of calcium-dependent nitric oxide synthases by sex hormones.
Weiner, C. P., Lizasoaín, I., Baylis, S. A., Knowles, R. G., Charles, I. G., & Moncada, S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.5212 · Cited by 1,066 · see citing works
Reid, I. A., Morris, B. J., & Ganong, W. F. (1978) · Annual Review of Physiology · doi:10.1146/annurev.ph.40.030178.002113 · Cited by 957 · see citing works
Finasteride in the treatment of men with androgenetic alopecia
Kaufman, K. D., Olsen, E. A., Whiting, D., Savin, R. C., DeVillez, R. L., Bergfeld, W. F., Price, V. H., Neste, D. J. V., Roberts, J. L., Hordinsky, M. K., et al. (1998) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(98)70007-6 · Cited by 767 · see citing works
Ushio‐Fukai, M., Zafari, A. M., Fukui, T., Ishizaka, N., & Griendling, K. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23317 · Cited by 766 · see citing works
Peroxynitrite‐mediated oxidative protein modifications
Ischiropoulos, H., & Al‐Mehdi, A. B. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00307-u · Cited by 610 · see citing works
The isoprostanes: Unique bioactive products of lipid peroxidation
Morrow, J. D., & Roberts, L. J. (1997) · Progress in Lipid Research · doi:10.1016/s0163-7827(97)00001-5 · Cited by 556 · see citing works
Takahashi, K., Nammour, T., Fukunaga, M., Ebert, J., Morrow, J. D., Roberts, L. J., Hoover, R. L., & Badr, K. F. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115826 · Cited by 510 · see citing works
Coronary Heart Disease Risk Factors in Women With Polycystic Ovary Syndrome
Talbott, E. O., Guzick, D. S., Clerici, A., Berga, S. L., Detre, K. M., Weimer, K., & Kuller, L. H. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.7.821 · Cited by 499 · see citing works
Siragy, H. M., & Carey, R. M. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119531 · Cited by 486 · see citing works
Effects of Estrogen Replacement Therapy on the Renin-Angiotensin System in Postmenopausal Women
Schunkert, H., Danser, A. H. J., Hense, H.-W., Derkx, F. H. M., Ku¨rzinger, S., & Riegger, G. A. J. (1997) · Circulation · doi:10.1161/01.cir.95.1.39 · Cited by 438 · see citing works
24-h ambulatory blood pressure in 352 normal Danish subjects, related to age and gender*
Wiinberg, N., Høegholm, A., Christensen, H. R., Bang, L. E., Mikkelsen, K. L., Nielsen, P. E., Svendsen, T. L., Kampmann, J. P., Madsen, N. H., & Bentzon, M. W. (1995) · American Journal of Hypertension · doi:10.1016/0895-7061(95)00216-2 · Cited by 412 · see citing works
Estrogen Modulates AT <sub>1</sub> Receptor Gene Expression In Vitro and In Vivo
Nickenig, G., Bäumer, A. T., Grohè, C., Kahlert, S., Strehlow, K., Rosenkranz, S., Stäblein, A., Beckers, F., Smits, J. F. M., Daemen, M. J. A. P., et al. (1998) · Circulation · doi:10.1161/01.cir.97.22.2197 · Cited by 409 · see citing works
Remission of Essential Hypertension after Renal Transplantation
Curtis, J. J., Luke, R. G., Dustan, H. P., Kashgarian, M. J., Whelchel, J. D., Jones, P., & Diethelm, A. G. (1983) · New England Journal of Medicine · doi:10.1056/nejm198310273091702 · Cited by 394 · see citing works
Laughlin, G. A., Barrett-Connor, E. L., Kritz‐Silverstein, D. C., & von Mühlen, D. G. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.2.6405 · Cited by 381 · see citing works
Tyrosine Modification by Reactive Nitrogen Species: A Closer Look
Vandervliet, A., Eiserich, J. P., O’Neill, C., Halliwell, B. B., & Cross, C. E. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1303 · Cited by 373 · see citing works
Role of Angiotensin and Oxidative Stress in Essential Hypertension
Romero, J. C., & Reckelhoff, J. F. (1999) · Hypertension · doi:10.1161/01.hyp.34.4.943 · Cited by 358 · see citing works
Self-citationReckelhoff, J. F., Zhang, H., & Granger, J. P. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.435 · Cited by 336 · see citing works
Self-citationVilla, L. M., Salas, E., Darley-Usmar, V. M., Radomski, M. W., & Moncada, S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12383 · Cited by 291 · see citing works
Gender Differences in Development of Hypertension in Spontaneously Hypertensive Rats
Reckelhoff, J. F., Zhang, H., & Srivastava, K. (2000) · Hypertension · doi:10.1161/01.hyp.35.1.480 · Cited by 272 · see citing works
Self-citationImpact of gender on the renal response to angiotensin II
Miller, J. A., Anacta, L. A., & Cattran, D. C. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00260.x · Cited by 255 · see citing works
Androgen-dependent angiotensinogen and renin messenger RNA expression in hypertensive rats.
Chen, Y., Naftilan, A. J., & Oparil, S. (1992) · Hypertension · doi:10.1161/01.hyp.19.5.456 · Cited by 245 · see citing works
Gender Differences in Hypertension in Spontaneously Hypertensive Rats
Reckelhoff, J. F., Zhang, H., Srivastava, K., & Granger, J. P. (1999) · Hypertension · doi:10.1161/01.hyp.34.4.920 · Cited by 206 · see citing works
Self-citationAndrogen regulation of rat renal angiotensinogen messenger RNA expression.
Ellison, K., Ingelfinger, J. R., Pivor, M., & Dzau, V. J. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114102 · Cited by 200 · see citing works
August, P., & Oparil, S. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5724 · Cited by 198 · see citing works
Abnormal pressure natriuresis. A cause or a consequence of hypertension?
Hall, J. E., Mizelle, H. L., Hildebrandt, D. A., & Brands, M. W. (1990) · Hypertension · doi:10.1161/01.hyp.15.6.547 · Cited by 193 · see citing works
Angiotensin II and long-term arterial pressure regulation: the overriding dominance of the kidney.
Hall, J. E., BRANDS, M., & Henegar, J. R. (1999) · PubMed · Cited by 185 · see citing works
Estradiol With or Without Progesterone and Ambulatory Blood Pressure in Postmenopausal Women
Seely, E. W., Walsh, B. W., Gerhard, M. D., & Williams, G. H. (1999) · Hypertension · doi:10.1161/01.hyp.33.5.1190 · Cited by 176 · see citing works
Sexual dimorphism of blood pressure in spontaneously hypertensive rats is androgen dependent
Chen, Y.-F., & Meng, Q. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90428-e · Cited by 172 · see citing works
Hypertension in Women: What is Really Known?
Anastos, K., Charney, P., Charon, R., Cohen, E., Jones, C. Y., Marte, C., Swiderski, D. M., Wheat, M. E., & Williams, S. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-4-287 · Cited by 158 · see citing works
Yura, T., Fukunaga, M., Khan, R., Nassar, G., Badr, K. F., & Montero, A. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00596.x · Cited by 155 · see citing works
Sex difference in the development of deoxycorticosterone-salt hypertension in the rat.
Ouchi, Y., Share, L., Crofton, J. T., et al. (1987) · Hypertension · doi:10.1161/01.hyp.9.2.172 · Cited by 151 · see citing works
Ambulatory Blood Pressure Recordings in Children and Adolescents
Harshfield, G. A., Alpert, B. S., Pulliam, D. A., et al. (1994) · PEDIATRICS · doi:10.1542/peds.94.2.180 · Cited by 149 · see citing works
Increased Expression of Endothelial Constitutive Nitric Oxide Synthase in Rat Aorta during Pregnancy
Goetz, R. M., Morano, I. L., Calovini, T., Studer, R., & Holtz, J. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2750 · Cited by 149 · see citing works
Ganten, U., Schröder, G., Witt, M., Zimmermann‐Viehoff, F., Ganten, D., & Stock, G. (1989) · PubMed · Cited by 148 · see citing works
Ambulatory Blood Pressure Monitoring In A Nonacademic Setting: Effects of Age and Sex
Khoury, S., Yavows, S. A., O’Brien, T. K., & Sowers, J. R. (1992) · American Journal of Hypertension · doi:10.1093/ajh/5.9.616 · Cited by 143 · see citing works
Role of Female Sex Hormones in the Development and Reversal of Dahl Hypertension
Hinojosa‐Laborde, C., Lange, D. L., & Haywood, J. R. (2000) · Hypertension · doi:10.1161/01.hyp.35.1.484 · Cited by 142 · see citing works
The Intravenous Furosemide Test: A Simple Way to Evaluate Renin Responsiveness
Kaplan, N. M., Kem, D. C., HOLLAND, O. B., Kramer, N. J., HIGGINS, J., & Gómez-Sánchez, C. E. (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-84-6-639 · Cited by 141 · see citing works
Gonadal Hormones Modulate Deoxycorticosterone-Salt Hypertension in Male and Female Rats
Crofton, J. T., & Share, L. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.494 · Cited by 135 · see citing works
Changes in nitric oxide precursor, L-arginine, and metabolites, nitrate and nitrite, with aging
Reckelhoff, J. F., Kellum, J. A., Blanchard, E. J., Bacon, E. E., Wesley, A. J., & Kruckeberg, W. C. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00521-4 · Cited by 129 · see citing works
Self-citationØverlie, I., Moen, M. H., Mørkrid, L., Skjaeraasen, J., & Holte, A. (1999) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.1999.780714.x · Cited by 123 · see citing works
Sexual dimorphism of blood pressure in spontaneously hypertensive rats
Ganten, U., der, G. S., Witt, M., et al. (1989) · Journal of Hypertension · doi:10.1097/00004872-198909000-00005 · Cited by 122 · see citing works
Long-term effects of finasteride on prostate tissue composition
Marks, L. S., Partin, A. W., Dorey, F. J., et al. (1999) · Urology · doi:10.1016/s0090-4295(98)00567-6 · Cited by 117 · see citing works
The HERS Trial Results: Paradigms Lost?
Herrington, D. M. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-6-199909210-00012 · Cited by 112 · see citing works
Role of Gonadal Hormones in Hypertension in the Dahl Salt-Sensitive Rat
Rowland, N. E., & Fregly, M. J. (1992) · Clinical and Experimental Hypertension · doi:10.3109/10641969209036195 · Cited by 111 · see citing works
Renin relationship to sex, race and age in a normotensive population.
James, G. D., Sealey, J. E., Müller, F., et al. (1986) · PubMed · Cited by 105 · see citing works
Iams, S. G., McMurtry, J. P., & Wexler, B. C. (1979) · Endocrinology · doi:10.1210/endo-104-5-1357 · Cited by 96 · see citing works
Comparison of fast and slow pressor effects of angiotensin II in the conscious rat
Brown, A. J., CASALS‐STENZEL, J., Gofford, S., Lever, A. F., & Morton, J. J. (1981) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1981.241.3.h381 · Cited by 95 · see citing works
Retardation in the development of spontaneous hypertension in SH rats by gonadectomy.
Iams, S. G., & Wexler, B. C. (1977) · PubMed · Cited by 93 · see citing works
Mattsson, L., Cullberg, G., Hamberger, L., Samsioe, G., & Silfverstolpe, G. (1984) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48142-2 · Cited by 93 · see citing works
Subpressor Doses of Angiotensin II Increase Plasma F 2 -Isoprostanes in Rats
Reckelhoff, J. F., Zhang, H., Srivastava, K., Roberts, L. J., Morrow, J. D., & Romero, J. C. (2000) · Hypertension · doi:10.1161/01.hyp.35.1.476 · Cited by 88 · see citing works
Self-citationTestosterone increases thromboxane A2 receptors in cultured rat aortic smooth muscle cells.
Masuda, A., Mathur, R. S., & Halushka, P. V. (1991) · Circulation Research · doi:10.1161/01.res.69.3.638 · Cited by 85 · see citing works
Gonadectomy-induced reduction of blood pressure in adult spontaneously hypertensive rats
Masubuchi, Y., Kumai, T., Uematsu, A., KOMORIYAMA, K., & Hirai, M. (1982) · European Journal of Endocrinology · doi:10.1530/acta.0.1010154 · Cited by 82 · see citing works
Role of vasopressin, the renin???angiotensin system and sex in Dahl salt-sensitive hypertension
Crofton, J. T., Ota, M., & Share, L. (1993) · Journal of Hypertension · doi:10.1097/00004872-199310000-00005 · Cited by 81 · see citing works
Akkad, A. (1997) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(97)84258-5 · Cited by 79 · see citing works
Sexual dimorphism in renal function and hormonal status of New Zealand genetically hypertensive rats
Ashton, N., & Balment, R. (1991) · European Journal of Endocrinology · doi:10.1530/acta.0.1240091 · Cited by 74 · see citing works
Smithies, O. (1997) · Hypertension · doi:10.1161/01.hyp.30.6.1318 · Cited by 67 · see citing works
Reference values for ambulatory blood pressure: a meta-analysis.
Staessen, J. A., Fagard, R. H., Lijnen, P. J., et al. (1990) · PubMed · Cited by 67 · see citing works
Sex vulnerability in the subtotal nephrectomy model of glomerulosclerosis in the rat.
Lombet, Sg, A., Ps, A., et al. (1989) · PubMed · Cited by 65 · see citing works
Øverlie, I., Moen, M. H., Mørkrid, L., et al. (1999) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1080/j.1600-0412.1999.780714.x · Cited by 65 · see citing works
VANITTERSUM, F., VANBAAL, W., Kenemans, P., Mijatovic, V., Donker, A. J. M., VANDERMOOREN, M., & Stehouwer, C. D. A. (1998) · American Journal of Hypertension · doi:10.1016/s0895-7061(98)00165-4 · Cited by 64 · see citing works
Schunkert, H. (1999) · American Journal of Hypertension · doi:10.1016/s0895-7061(99)00128-4 · Cited by 60 · see citing works
Differences in Rat Kidney Morphology between Males, Females and Testosterone-Treated Females
Oudar, O., Elger, M., Bankir, L., Ganten, D., Ganten, U., & Kriz, W. (1991) · Kidney & Blood Pressure Research · doi:10.1159/000173392 · Cited by 58 · see citing works
Intrarenal renin-angiotensin system in renal physiology and pathophysiology.
Johnston, C. I., Fabris, B., & Jandeleit, K. (1993) · PubMed · Cited by 57 · see citing works
Inhibition of aldosterone production by testosterone in male rats
Kau, M., Lo, M.-J., Wang, S., Tsai, S.-C., Chen, J.-J., Chiao, Y., Yeh, J.-Y., Lin, H., Shum, A. Y.-C., Fang, V. S., et al. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90123-3 · Cited by 55 · see citing works
Jiroutek, M. R., Chen, M., Johnston, C. C., & Longcope, C. (1998) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-199805020-00006 · Cited by 54 · see citing works
Gender and Dietary NaCl in Spontaneously Hypertensive and Wistar-Kyoto Rats
Calhoun, D. A., Zhu, S., Chen, Y.-F., et al. (1995) · Hypertension · doi:10.1161/01.hyp.26.2.285 · Cited by 54 · see citing works
Attenuation of vascular relaxation after development of tachyphylaxis to peroxynitrite in vivo
Benkusky, N. A., Lewis, S. J., & Kooy, N. W. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.275.2.h501 · Cited by 54 · see citing works
Testosterone-Induced Hypertension in the Rat
Colby, H. D., Skelton, F. R., & Brownie, A. C. (1970) · Endocrinology · doi:10.1210/endo-86-5-1093 · Cited by 51 · see citing works
Transdermal oestrogen reduces daytime blood pressure in hypertensive women
Manhem, K., Ahlm, H., Milsom, I., & Svensson, A.-M. (1998) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1000563 · Cited by 50 · see citing works
Pripp, U., Hall, G., Csemiczky, G., Eksborg, S., Landgren, B.-M., & Schenck-Gustafsson, K. G. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917100-00004 · Cited by 50 · see citing works
Hall, J. E., Guyton, A. C., & Brands, M. W. (1995) · Cited by 50 · see citing works
Castration inhibits glomerular hypertrophy and proteinuria in uninephrectomized male rats
Gafter, U., Ben-Bassat, M., & Levi, J. (1990) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1990.tb01871.x · Cited by 49 · see citing works
Ovarian testosterone secretion during perimenopause
Ala‐Fossi, S., Mäenpää, J., Aine, R., & Punnonen, R. (1998) · Maturitas · doi:10.1016/s0378-5122(98)00034-6 · Cited by 45 · see citing works
Blood pressure and menopausal transition
Luoto, R. M., Sharrett, A. R., Schreiner, P. J., et al. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018010-00005 · Cited by 40 · see citing works
Hartmann, B. W., Kirchengast, S., Albrecht, A. E., Laml, T., Söregi, G., & Huber, J. C. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000291503 · Cited by 39 · see citing works
Bachmann, H., Horacek, U., Leowsky, M., et al. (1987) · PubMed · Cited by 33 · see citing works
Jiroutek, M. R., Chen, M., Johnston, C. C., & Longcope, C. (1998) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-199822010-00006 · Cited by 33 · see citing works
Elevation in arterial blood pressure following the development of tachyphylaxis to peroxynitrite
Kooy, N. W., & Lewis, S. J. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00343-3 · Cited by 31 · see citing works
Živković, T. B., Babic, D., Marinković, J., & Prelević, G. M. (1998) · Maturitas · doi:10.1016/s0378-5122(98)00030-9 · Cited by 28 · see citing works
Influence of isoprostanes on vasoconstrictor effects of noradrenaline and angiotensin II
Sametz, W., Grobuschek, T., Hammer-Kogler, S., et al. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00437-9 · Cited by 28 · see citing works
Testosterone Effect on Renin System in Rats
Katz, F. H., & Roper, E. (1977) · Experimental Biology and Medicine · doi:10.3181/00379727-155-39800 · Cited by 27 · see citing works
Renal transplantation between male and female spontaneously hypertensive rats.
Harrap, S. B., Wang, B. Z., & MacLellan, D. G. (1992) · Hypertension · doi:10.1161/01.hyp.19.5.431 · Cited by 26 · see citing works
The Sexual Dimorphism of High Blood Presssure
Calhoun, D. A., & Oparil, S. (1998) · Cardiology in Review · doi:10.1097/00045415-199811000-00012 · Cited by 25 · see citing works
Reference values for ambulatory blood pressure: a population study.
Staessen, J., Bulpitt, C., Fagard, R., Mancia, G., O??Brien, E., Thijs, L., Vyncke, G., & Amery, A. (1991) · Journal of Hypertension - Supplement · doi:10.1097/00004872-199112000-00144 · Cited by 22 · see citing works
Effect of Castration on the Experimental Renal Hypertension of the Rat
Mályusz, M., Ehrens, H. J., & Wrigge, P. (2008) · The Nephron journals/Nephron journals · doi:10.1159/000183437 · Cited by 16 · see citing works
Slow developing pressor effect of angiotensin II and vascular structure.
Lever, A. F. (1993) · PubMed · Cited by 16 · see citing works
Soranno, D., Prasad, V., David, R., et al. (1999) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.1999.12.2.215 · Cited by 14 · see citing works
Gender differences in the response of SHR to acute and chronic superoxide dismutase mimetic, TEMPOL
Reckelhoff, J. F. (2000) · American Journal of Hypertension · doi:10.1016/s0895-7061(00)01026-8 · Cited by 1 · see citing works
Self-citationSharkey, L. C. (2000) · American Journal of Hypertension · doi:10.1016/s0895-7061(00)01024-4 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 6
- Weiner CP, Lizasain I, Baylis SA, Knowles RG, Charles IG, Moncada S. Induction of calcium dependent NO synthase by sex hormones. Proc Natl Acad Sci U S A. 1994;91:5212-5216.
- Reckelhoff JF, Zhang H, Srivastava K. Gender differences in the devel- opment of hypertension in SHR: role of the renin-angiotensin system. Hypertension. 2000;35:480 -483.
- Hennington BS, Henegar L, Sinning AR, Granger JP, Reckelhoff JF. Localization of androgen receptors in the kidney of male rats. Hyper- tension. 1997;30:510. Abstract.
- Takahashi K, Nammour TM, Fukunaga M, Ebert J, Morrow JD, Roberts ILJ, Hoover RL, Badr KF. Glomerular action of a free radical generated novel prostaglandin, 8-epi-prostaglandin F 2-alpha , in the rat. J Clin Invest. 1992;90:136 -141.
- Harrison-Bernard LM, Raij L. Post-ovariectomy hypertension is linked to upregulation of renal angiotensin II type I (AT1) receptors and increased salt-sensitivity. Hypertension. 1999;34:36. Abstract.
- Raij L, Jaimes E, Hayakawa H. Development of post-ovariectomy hyper- tension is linked to salt sensitivity. Hypertension. 1998;32:601. Abstract.
Cited by
Sorted by citations
Mancia, G., Kreutz, R., Brunström, M., Burnier, M., Grassi, G., Januszewicz, A., Muiesan, M. L., Tsioufis, K., Agabiti-Rosei, E., Algharably, E. A. E., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003480 · Cited by 3,473 · see citing works
Zhou, B., Bentham, J., Di Cesare, M., Bixby, H., Danaei, G., Cowan, M. J., Paciorek, C. J., Singh, G., Hajifathalian, K., Bennett, J. E., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(16)31919-5 · Cited by 2,579 · see citing works
Sex bias in neuroscience and biomedical research
Beery, A. K., & Zucker, I. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.002 · Cited by 1,763 · see citing works
Palomba, S., Falbo, A., Zullo, F., & Orio, F. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0030 · Cited by 426 · see citing works
Renin angiotensin system and gender differences in the cardiovascular system
Fischer, M. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00479-5 · Cited by 384 · see citing works
Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring
Fine, J., Branan, K. L., Rodriguez, A. J., Boonya-ananta, T., Ajmal, Ramella-Roman, J. C., McShane, M. J., & Coté, G. L. (2021) · Biosensors · doi:10.3390/bios11040126 · Cited by 348 · see citing works
Sexual dimorphic pattern of renal transporters and electrolyte homeostasis
Veiras, L. C., Girardi, A. C. C., Curry, J., Pei, L., Ralph, D. L., Tran, A., Castelo-Branco, R. C., Pastor-Soler, N., Arranz, C. T., Yu, A. S. L., et al. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017030295 · Cited by 316 · see citing works
Gerdts (2022) · doi:10.1093/eurheartj/ehac470 · Cited by 241 · see citing works
Of mice and men: the evolving phenotype of aromatase deficiency
Jones, M. E. E., Chin Boon, W., Proietto, J., & Simpson, E. R. (2006) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2006.01.004 · Cited by 193 · see citing works
Traish, A. M., Haider, A., Haider, K. S., Doros, G., & Saad, F. (2017) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248417691136 · Cited by 130 · see citing works
Men's mental health help-seeking behaviors: an intersectional analysis
Parent, M. C., Hammer, J. H., Bradstreet, T. C., Schwartz, E. N., & Jobe, T. (2018) · American Journal of Men's Health · doi:10.1177/1557988315625776 · Cited by 124 · see citing works
Capone, C., Faraco, G., Peterson, J. R., Coleman, C., Anrather, J., Milner, T. A., Pickel, V. M., Davisson, R. L., & Iadecola, C. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6262-11.2012 · Cited by 106 · see citing works
Jensen, G., Lenninger, M., Ero, M. P., & Benson, K. (2016) · Integrated Blood Pressure Control · doi:10.2147/ibpc.s99553 · Cited by 71 · see citing works
Han, T. S., Conway, G. S., Willis, D. S., Krone, N., Rees, D. A., Stimson, R. H., Arlt, W., Walker, B. R., Ross, R. J., & (CaHASE), T. U. K. C. A. H. A. S. E. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1486 · Cited by 65 · see citing works
Hu, R., McDonough, A. A., & Layton, A. T. (2021) · iScience · doi:10.1016/j.isci.2021.102667 · Cited by 65 · see citing works
- Authors
- Reckelhoff, J. F.
- Affiliations
- University of Mississippi Medical Center (US)
- Corresponding author
- Reckelhoff, Jane F.
- ORCID
- Reckelhoff, Jane F.
- Venue
- Hypertension
- Published
- 2001-05
- Volume
- 37
- Issue
- 5
- Pages
- 1199-1208
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2041781505
- Cited by
- 1,268
- References
- 96
- Citations by year
- 2026: 45 · 2025: 71 · 2024: 71 · 2023: 78 · 2022: 76 · 2021: 67 · 2020: 62 · 2019: 50 · 2018: 71 · 2017: 66 · 2016: 70 · 2015: 53 · 2014: 44 · 2013: 45 · 2012: 49
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institutes of Health (51971, HL-51971)
- National Heart, Lung, and Blood Institute (HL‐51971, P01HL051971)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- sex differences in blood pressure, postmenopausal hypertension, androgens, estrogen loss, renin-angiotensin system, spontaneously hypertensive rats, ovariectomy, testosterone, oxidative stress, nitric oxide, hormone replacement therapy
- MeSH terms
- Androgens, Animals, Blood Pressure, Estrogens, Female, Humans, Hypertension, Male, Renin-Angiotensin System, Sex Characteristics, Testosterone, Postmenopause, Oxidative Stress, Hormone Replacement Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
