Cited by 103Calcium Carbonate Crystallization and InhibitionCrystallization and Solubility StudiesMicrobial Applications in Construction Materials

The multiple effects of amino acids on the early stages of calcium carbonate crystallization

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Picker, Andreas, Kellermeier, Matthias, Seto, Jong, Gebauer, Denis, Cölfen, Helmut·2012·Zeitschrift für Kristallographie - Crystalline Materials

Abstract

Proteins have found their way into many of Nature’s structures due to their structural stability, diversity in function and composition, and ability to be regulated as well as be regulators themselves. In this study, we investigate the constitutive amino acids that make up some of these proteins which are involved in CaCO 3 mineralization – either in nucleation, crystal growth, or inhibition processes. By assaying all 20 amino acids with vapor diffusion and in situ potentiometric titration, we have found specific amino acids having multiple effects on the early stages of CaCO 3 crystallization. These same amino acids have been independently implicated as constituents in liquid-like precursors that form mineralized tissues, processes believed to be key effects of biomineralization proteins in several biological model systems.

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Crossref · 10.1524/zkri.2012.1569

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  • Aspartic acids were shown to modify calcite crystal morphology by altering the surface energy at certain crystallographic facies.

    “Aspartic acids in particular were shown to modify calcite crystal morphology by altering the surface energy at certain crystallographic facies.36,42−44”

    From Organic Controls over Biomineral Ca-Mg Carbonate Compositions and Morphologies (2023) · cites this paper as [36]

    The Gas diffusion experiments section reports that L-aspartate produces calcite crystals with rounded edges and corners. It proposes face-selective adsorption as a possible explanation, but does not establish that aspartate alters surface energy at particular crystallographic faces. (LLM, conf=0.87)

    Experimental — accuracy not yet measured
  • Despite extensive works on the effects of amino acids on the calcium carbonate system, the effects of amino acids and chitins on Ca-Mg carbonate crystallization are poorly constrained.

    “Despite extensive works on the effects of amino acids on the calcium carbonate system,33−36 the effects of amino acids and chitins on Ca–Mg carbonate crystallization are poorly constrained.”

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Research works printed but not linked: 2

  1. [15]15. S. Weiner, L. Hood, Soluble-protein of organic matrix of mol- lusk shells -Potential template for shell formation. Science 1975, 190, 987-988.
  2. [43]43. A. C. Neira, M. S. Ferna ´ndez, J. Reutert, Effect of the crystal- lization chamber design on the polymorphs of calcium carbonate using the sitting-drop method. In Architecture and application of biomaterials and biomolecular materials; J. Y. Wong (ed.), Ma- terials Research Society: Warrendale, Pa., 2004.

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Authors
Picker, A., Kellermeier, M., Seto, J., Gebauer, D., & Cölfen, H.
Affiliations
University of Konstanz (DE)
Venue
Zeitschrift für Kristallographie - Crystalline Materials
Published
2012-10-15
Volume
227
Issue
11
Pages
744-757
ISSN
2194-4946 (ISSN-L)
OpenAlex
W2143726201
Cited by
103
References
67
Citations by year
2026: 14 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 9 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 3
FWCI
2.20
Type
journal article
Language
en
Open access
Locations
  • Zeitschrift für Kristallographie - Crystalline Materials (publishedVersion)
  • KOPS (University of Konstanz) (submittedVersion)
  • eSpace (Curtin University) (submittedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Calcium Carbonate Crystallization and Inhibition
  • Physical Sciences › Materials Science › Materials Chemistry › Crystallization and Solubility Studies
  • Physical Sciences › Environmental Science › Environmental Engineering › Microbial Applications in Construction Materials
Keywords
amino acids, calcium carbonate crystallization

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