The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
SIRT 5 promotes IDH 2 desuccinylation and G6 PD deglutarylation to enhance cellular antioxidant defense
Open accessAbstract
Excess in mitochondrial reactive oxygen species ( ROS ) is considered as a major cause of cellular oxidative stress. NADPH , the main intracellular reductant, has a key role in keeping glutathione in its reduced form GSH , which scavenges ROS and thus protects the cell from oxidative damage. Here, we report that SIRT 5 desuccinylates and deglutarylates isocitrate dehydrogenase 2 ( IDH 2) and glucose‐6‐phosphate dehydrogenase (G6 PD ), respectively, and thus activates both NADPH ‐producing enzymes. Moreover, we show that knockdown or knockout of SIRT 5 leads to high levels of cellular ROS . SIRT 5 inactivation leads to the inhibition of IDH 2 and G6 PD , thereby decreasing NADPH production, lowering GSH , impairing the ability to scavenge ROS , and increasing cellular susceptibility to oxidative stress. Our study uncovers a SIRT 5‐dependent mechanism that regulates cellular NADPH homeostasis and redox potential by promoting IDH 2 desuccinylation and G6 PD deglutarylation.
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Self-citationMitochondrial metabolites: undercover signalling molecules
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Metadata
- Authors
- Zhou, L., Wang, F., Sun, R., Chen, X., Zhang, M., Xu, Q., Wang, Y., Wang, S., Xiong, Y., Guan, K., Yang, P., Yu, H., & Ye, D.
- Venue
- EMBO reports
- Published
- 2016-04-09
- Volume
- 17
- Issue
- 6
- Pages
- 811-822
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2316887884
- Cited by
- 294
- References
- 42
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhou, L., Wang, F., Sun, R., Chen, X., Zhang, M., Xu, Q., Wang, Y., Wang, S., Xiong, Y., Guan, K., Yang, P., Yu, H., & Ye, D. (2016). SIRT 5 promotes IDH 2 desuccinylation and G6 PD deglutarylation to enhance cellular antioxidant defense. EMBO reports. https://doi.org/10.15252/embr.201541643
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