The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.
Development of broad‐spectrum human monoclonal antibodies for rabies post‐exposure prophylaxis
Open accessAbstract
Currently available rabies post-exposure prophylaxis (PEP) for use in humans includes equine or human rabies immunoglobulins (RIG). The replacement of RIG with an equally or more potent and safer product is strongly encouraged due to the high costs and limited availability of existing RIG. In this study, we identified two broadly neutralizing human monoclonal antibodies that represent a valid and affordable alternative to RIG in rabies PEP. Memory B cells from four selected vaccinated donors were immortalized and monoclonal antibodies were tested for neutralizing activity and epitope specificity. Two antibodies, identified as RVC20 and RVC58 (binding to antigenic site I and III, respectively), were selected for their potency and broad-spectrum reactivity. In vitro, RVC20 and RVC58 were able to neutralize all 35 rabies virus (RABV) and 25 non-RABV lyssaviruses. They showed higher potency and breath compared to antibodies under clinical development (namely CR57, CR4098, and RAB1) and commercially available human RIG. In vivo, the RVC20-RVC58 cocktail protected Syrian hamsters from a lethal RABV challenge and did not affect the endogenous hamster post-vaccination antibody response.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Fourthly, the effective dose of an antibody is strongly dependent on its characteristics, that is, potential limitations may be overcome with the right protein (De Benedictis et al, 2016).”
From mRNA mediates passive vaccination against infectious agents, toxins, and tumors (2017) · cites this paper as De Benedictis et al, 2016
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability
Katoh, K., & Standley, D. M. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst010 · Cited by 46,209
A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood
Guindon, S., & Gascuel, O. (2003) · Systematic Biology · doi:10.1080/10635150390235520 · Cited by 16,923
Database resources of the National Center for Biotechnology Information: update
Wheeler, D. L. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkh073 · Cited by 10,695
Estimating the Global Burden of Endemic Canine Rabies
Hampson, K., Coudeville, L., Lembo, T., Sambo, M. B., Kieffer, A., Attlan, M., Barrat, J., Blanton, J. D., Briggs, D. J., Cleaveland, S., et al. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003709 · Cited by 1,817
Gene splicing and mutagenesis by PCR-driven overlap extension
Heckman, K. L., & Pease, L. R. (2007) · Nature Protocols · doi:10.1038/nprot.2007.132 · Cited by 1,150
Tiller, T., Meffre, E., Yurasov, S., Tsuiji, M., Nussenzweig, M. C., & Wardemann, H. (2007) · Journal of Immunological Methods · doi:10.1016/j.jim.2007.09.017 · Cited by 1,078
Harpaz, R., Ortega‐Sanchez, I. R., & Seward, J. F. (2008) · PubMed · Cited by 1,018
Database resources of the National Center for Biotechnology Information
Sayers, E. W., Barrett, T., Benson, D. A., Bryant, S. H., Canese, K., Chetvernin, V., Church, D. M., DiCuccio, M. N., Edgar, R., Federhen, S., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn741 · Cited by 794
Sievers, F., & Higgins, D. G. (2014) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi0313s48 · Cited by 784
Traggiai, E., Becker, S., Subbarao, K., Kolesnikova, L., Uematsu, Y., Gismondo, M. R., Murphy, B. R., Rappuoli, R., & Lanzavecchia, A. (2004) · Nature Medicine · doi:10.1038/nm1080 · Cited by 697
Self-citation
Flagged first, then by citations
1 of the 63 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Atanasiu P, Cannon DA, Dean DJ, Fox JP, Habel K, Kaplan MM, Kissling RE, Koprowski H, Lepine P, Perez Gallardo F (1961) Rabies neutralizing antibody response to different schedules of serum and vaccine inoculations in non‐exposed persons. 3. Bull World Health Organ 25: 103–114
- Atanasiu P, Dean DJ, Habel K, Kaplan MM, Koprowski H, Lepine P, Serie C (1967) Rabies neutralizing antibody response to different schedules of serum and vaccine inoculations in non‐exposed persons. 4. Bull World Health Organ 36: 361–365
- Babes V, Lepp M (1889) Recherches sur la vaccination antirabique. Ann Inst Pasteur 3: 384–390
- Dietzgen R, Calisher C, Kurath G, Kuzmin I, Rodriguez L, Stone D, Tesh R, Tordo N, Walker P, Wetzel T et al (2011) Rhabdoviridae. In Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses, King AMQ, Adams MJ, Carstens EB, Lefkowitz EJ (eds), pp 686–714. Oxford, UK: Elsevier
Cited by
Sorted by citations
Items 101–102 of 102
Huaman, C., Xu, Y., Lott, N. M., Santorella, E. M., Rader, M., Strazzella, A., Clouse, C., King, J. M., Melnyk, M., Hong, J., et al. (2026) · Emerging Microbes & Infections · doi:10.1080/22221751.2026.2736987
Cai, M., Wu, X., 石磊泰, Tong, J., He, C., 聂建辉, Yang, Y., Ren, J., 李玉华, Mao, Q., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1960986
Metadata
- Authors
- De Benedictis, P., Minola, A., Rota Nodari, E., Aiello, R., Zecchin, B., Salomoni, A., Foglierini, M., Agatic, G., Vanzetta, F., Lavenir, R., Lepelletier, A., Bentley, E., Weiss, R., Cattoli, G., Capua, I., Sallusto, F., Wright, E., Lanzavecchia, A., Bourhy, H., & Corti, D.
- Affiliations
- Food and Agriculture Organization of the United Nations (IT)
- Institute for Research in Biomedicine (CH)
- Institut Pasteur (FR)
- University of Westminster (GB)
- University College London (GB)
- ETH Zurich (CH)
- Corresponding author
- Corti, Davide
- ORCID
- Venue
- EMBO Molecular Medicine
- Published
- 2016-03-18
- Volume
- 8
- Issue
- 4
- Pages
- 407-421
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- PMC
- PMC4818751
- OpenAlex
- W2298668359
- Cited by
- 103
- References
- 63
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 7 · 2023: 13 · 2022: 10 · 2021: 5 · 2020: 14 · 2019: 2 · 2018: 16 · 2017: 9 · 2016: 3
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- EMBO Molecular Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- WestminsterResearch (University of Westminster) (acceptedVersion)
- WestminsterResearch (University of Westminster) (acceptedVersion, cc-by)
- reroDoc Digital Library (submittedVersion)
- Sussex Research Online (University of Sussex) (submittedVersion, cc-by)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Italian Ministry of Health (RC IZSVe 08/2009)
- Helmut Horten Foundation
- Swiss Vaccine Research Institute
- FAO/National RC for Rabies, IZSVe‐Italy
- IAEA Laboratories‐Austria
- Topics
- Life Sciences › Immunology and Microbiology › Virology › Rabies epidemiology and control
- Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- rabies post-exposure prophylaxis, human monoclonal antibodies, broadly neutralizing antibodies, rabies virus, lyssaviruses, memory B cells, antibody epitope specificity, neutralizing activity
- MeSH terms
- Animals, Antibodies, Monoclonal, Antibodies, Viral, Disease Models, Animal, Humans, Immunization, Passive, Immunologic Factors, Mesocricetus, Rabies, Rabies virus, Survival Analysis, Treatment Outcome, Post-Exposure Prophylaxis, Antibodies, Neutralizing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
