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Cited by 65biodegradable polymer synthesis and propertiesMicrobial Metabolic Engineering and BioproductionBiopolymer Synthesis and Applications

Mathematical Modelling as a Tool for Optimized PHA Production

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Novak, M.·2015·Chemical and Biochemical Engineering Quarterly
DOI 10.15255/cabeq.2014.2101
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Abstract

The potential of poly(hydroxyalkanoates) (PHAs) to replace conventional plastic materials justifies the increasing attention they have drawn both at lab-scale and in industrial biotechnology. The improvement of large-scale productivity and biochemical/genetic properties of producing strains requires mathematical modeling and process/strain optimization procedures. Current models dealing with structurally diversified PHAs, both structured and unstructured, can be divided into formal kinetic, low-structured, dynamic, metabolic (high-structured), cybernetic, neural networks and hybrid models; these attempts are summarized in this review. Characteristic properties of specific groups of models are stressed in light of their benefit to the better understanding of PHA biosynthesis, and their applicability for enhanced productivity. Unfortunately, there is no single type of mathematical model that expresses exactly all the characteristics of producing strains and/or features of industrial-scale plants; in addition, the different requirements for modelling of PHA production by pure cultures or mixed microbial consortia have to be addressed. Therefore, it is crucial to sophisticatedly adapt and fine-tune the modelling approach accordingly to actual processes, as the case arises. For “standard microbial cultivations and everyday practices”, formal kinetic models (for simple cases) and “low-structured” models will be appropriate and of great benefit. They are relatively simple and of low computational demand. To overcome the specific weaknesses of different established model types, some authors use hybrid models. Here, satisfying compromises can be achieved by combining mechanistic, cybernetic, and neural and computational fluid dynamics (CFD) models. Therefore, this hybrid modelling approach appears to constitute the most promising solution to generate a holistic picture of the entire PHA production process, encompassing all the benefits of the original modelling strategies. Complex growth media require a higher degree of model structuring. For scientific purposes and advanced development of industrial equipment in the future, real systems will be modelled by highly organized hybrid models. All solutions related to modelling PHA production are discussed in this review.

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  • Various biopolymers from food wastes such as PHAs, PBAT, PHB, polylactic acid and polyesters have been identified and investigated and promising results are obtained.

    “Various biopolymers from food wastes such as PHAs, polybutylene adipate terephthalate (PBAT), polyhydroxybutyrate (PHB), polylactic acid and polyesters have been identified and investigated and promising results are obtained [108,109,110].”

    From Food Waste Biorefinery: Pathway towards Circular Bioeconomy (2021) · cites this paper as [109]

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Authors
Novak, M.
Affiliations
University of Zagreb (HR)
Corresponding author
Novak, M.
Venue
Chemical and Biochemical Engineering Quarterly
Publisher
Croatian Society of Chemical Engineers/HDKI
Published
2015-07-12
Volume
29
Issue
2
Pages
183-220
ISSN
  • 0352-9568 (ISSN-L)
  • 1846-5153
DOI
10.15255/cabeq.2014.2101
OpenAlex
W1474972285
Cited by
65
References
126
Citations by year
2026: 4 · 2025: 8 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 11 · 2016: 4 · 2015: 1
FWCI
2.66
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Chemical and Biochemical Engineering Quarterly (publishedVersion, cc-by)
  • Hrčak Portal of scientific journals of Croatia (University Computing Centre) (submittedVersion, other-oa)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biopolymer Synthesis and Applications
Keywords
polyhydroxyalkanoates, PHA production, mathematical modeling, kinetic model, metabolic modeling, cybernetic model, neural network model, hybrid model, computational fluid dynamics, microbial consortia, bioprocess optimization, biodegradable plastics

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