Coenzyme Q10 Supplementation for Diabetes and Its Complications: An Overview
Open accessAbstract
This article reviews the potential role of dietary supplementation with coenzyme Q10 (CoQ10) for the management of patients with type 2 diabetes. The rationale for supplementation with CoQ10 is based on its key roles in cellular energy metabolism and as an antioxidant, and its potential mediation of oxidative stress and inflammation, which have been implicated in the pathogenesis of diabetes. Randomised controlled clinical trials have demonstrated that supplementation with CoQ10 can significantly improve glycaemic control, as well as improving vascular dysfunction. Supplementation with CoQ10 may be of particular importance in type 2 diabetics prescribed statins and in those with fatty liver disease. Supplemental CoQ10 is usually well tolerated, with no significant adverse effects reported in long-term use. The importance of product quality and bioavailability cannot be over-emphasised, since this may be a factor in the disparity of findings from clinical trials supplementing CoQ10.
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A lack of CoQ10 has been related to several conditions, including aging and neurological disorders.
“A lack of CoQ10 has been related to several conditions, including aging and neurological disorders [83,84,85,86,87,88,89] (Table 1).”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [85]
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- Authors
- Mantle, D.
- Affiliations
- Pharma Nord (United Kingdom) (GB)
- Corresponding author
- Mantle, David
- Venue
- British Journal of Diabetes
- Publisher
- ABCD Diabetes Care, Ltd.
- Published
- 2017-12-15
- Volume
- 17
- Issue
- 4
- Pages
- 145-148
- ISSN
- 2397-6233 (ISSN-L)
- 2397-6241
- OpenAlex
- W2770374668
- Cited by
- 21
- References
- 38
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- British Journal of Diabetes (publishedVersion)
- British Journal of Diabetes (publishedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- coenzyme Q10, type 2 diabetes, diabetes complications, dietary supplementation, glycemic control, oxidative stress, inflammation, vascular dysfunction, statins, hepatic steatosis, bioavailability, antioxidants
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