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Mesenchymal Stem Cells Decrease Tunnel Widening of Anterior Cruciate Ligament Reconstruction in Rabbit Model
Open accessAbstract
BACKGROUND AND OBJECTIVES: The study investigated the effect of mesenchymal stem cells (MSCs) or fibrin glue on tunnel widening after anterior cruciate ligament (ACL) reconstruction compared with biologic free control without any biologic agents in the rabbit model. METHODS AND RESULTS: ACL reconstructions were performed in 18 New Zealand white rabbits. All animals were divided into 3 groups according to the following reconstruction conditions and euthanized 12 weeks postoperatively for radiologic and histologic analyses. Thirty-two knees (control group=10; fibrin group=11; MSCs group=11) were finally evaluated. On micro-CT scan, mean femoral tunnel widening on oblique-sagittal image was 0.7±0.4 mm in the control group, 0.22±0.1 mm in the fibrin group and 0.25±0.1 mm in the MSCs group (p=0.001). Fibrin group and MSCs group showed significant differences compared with control group (p=0.002, 0.002). Mean tibial tunnel widening on oblique-sagittal image was 0.76±0.5 mm, 0.27±0.1 mm and 0.29±0.2 mm in the control, fibrin and MSCs group. Fibrin and MSCs group showed significant differences compared with control group (p=0.017, 0.014). Hounsfield Units (HU) were not significantly different between 3 groups (p＞0.05). Histological analysis revealed that the architecture of graft in the MSCs group featured hypercellularity and compact collagen deposit. CONCLUSION: ACL reconstruction using MSCs seemed decrease tunnel widening in rabbit model. Further study with large animals is required to confirm efficacy on decreasing tunnel widening.
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Tissue-engineering strategies involving fibroblasts or stem cell transplantation, gene regulation, and bioengineering have been attempted to enhance anterior cruciate ligament reconstruction outcomes.
“To overcome such a time-consuming healing process, which leads to weaker reparative scar tissue, tissue-engineering strategies that involve fibroblasts or stem cell transplantation, gene regulation, and bioengineering have been attempted to enhance ACLR outcomes [13–18].”
From A new biological enhancement therapy for anterior cruciate ligament reconstruction: the preclinical proof of anterior cruciate ligament reconstruction with tendon graft reseeded with autologous anterior cruciate ligament-derived cells (2025) · cites this paper as [16]
The Introduction describes stem-cell therapy as a strategy to improve ACL reconstruction, and the Methods report transplanting mesenchymal stem cells in a rabbit reconstruction model. The paper does not establish that its own approach involved fibroblast transplantation or gene regulation; those appear only in titles in its References. Thus it supports the stem-cell part of the grouped claim, not the full list of strategies. (LLM, conf=0.85)
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Metadata
- Authors
- Hur, C.-I., Ahn, H.-W., Seon, J.-K., Song, E.-K., & Kim, G.-E.
- Affiliations
- Chonnam National University Hwasun Hospital (KR)
- Chonnam National University (KR)
- Corresponding author
- Seon, Jong-Keun
- Venue
- International Journal of Stem Cells
- Published
- 2019-03-30
- Volume
- 12
- Issue
- 1
- Pages
- 162-169
- ISSN
- 2005-3606 (ISSN-L)
- 2005-5447
- PMC
- PMC6457700
- OpenAlex
- W2907514862
- Cited by
- 15
- References
- 39
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2021: 7 · 2020: 4
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- International Journal of Stem Cells (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Keywords
- mesenchymal stem cells, anterior cruciate ligament reconstruction, tunnel widening, fibrin glue, rabbit model, bone grafting, graft histology, micro-CT
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