The role and specific mechanism of OCT4 in cancer stem cells: A review
Open accessAbstract
Recently, evidences show that cancer stem cells (CSCs) are a type of cancer cell group with self-renewal and play a huge role in tumor recurrence, metastasis, and drug resistance. Finding new treatment directions and targets for cancer prognosis and reducing mortality has become a top priority. OCT4, as a transcription factor, participates in maintaining the stem characteristics of CSCs, but the mechanism of OCT4 is often overlooked. In this review, we try to illustrate the mechanism by which OCT4 plays a role in CSCs from the perspective of genetic modification of OCT4, non-coding RNA, complexes and signaling pathways associated with OCT4. Our ultimate goal is to provide new targets for cancer treatment to prolong the survival of cancer patients.
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For lung cancer, ALDH, CD44, Oct4, c-kit, and Nestin are among the most frequently observed CSCs markers that promote tumor development.
“For lung cancer, ALDH, CD44, Oct4, c-kit, and Nestin were shown to be some of the most frequently observed CSCs markers which promote tumor development [53,54,85,86,87].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [85]
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- Authors
- Zhang, Q., Han, Z., Zhu, Y., Chen, J., & Li, W.
- Affiliations
- First Hospital of Jilin University (CN)
- Corresponding author
- Li, Wei
- Venue
- International Journal of Stem Cells
- Published
- 2020-11-30
- Volume
- 13
- Issue
- 3
- Pages
- 312-325
- ISSN
- 2005-3606 (ISSN-L)
- 2005-5447
- PMC
- PMC7691851
- OpenAlex
- W3080370859
- Cited by
- 91
- References
- 138
- Citations by year
- 2026: 9 · 2025: 20 · 2024: 23 · 2023: 19 · 2022: 14 · 2021: 6
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- International Journal of Stem Cells (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (2018YFA0106902, 81372835 and 81670143, #81372835, 81670143)
- National Key Research and Development Program of China (2018YFA0106902, 81670143, 81372835)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- Oct4, cancer stem cells, transcription factors, self-renewal, tumor recurrence, metastasis, drug resistance, non-coding RNA, protein complexes, signaling pathways, therapeutic target
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