Cited by 91Cancer Cells and MetastasisPluripotent Stem Cells ResearchMesenchymal stem cell research

The role and specific mechanism of OCT4 in cancer stem cells: A review

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Zhang, Qi, Han, Zhenzhen, Zhu, Yanbo, Chen, Jingcheng, Li, Wei·2020·International Journal of Stem Cells

Abstract

Recently, evidences show that cancer stem cells (CSCs) are a type of cancer cell group with self-renewal and play a huge role in tumor recurrence, metastasis, and drug resistance. Finding new treatment directions and targets for cancer prognosis and reducing mortality has become a top priority. OCT4, as a transcription factor, participates in maintaining the stem characteristics of CSCs, but the mechanism of OCT4 is often overlooked. In this review, we try to illustrate the mechanism by which OCT4 plays a role in CSCs from the perspective of genetic modification of OCT4, non-coding RNA, complexes and signaling pathways associated with OCT4. Our ultimate goal is to provide new targets for cancer treatment to prolong the survival of cancer patients.

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Authors
Zhang, Q., Han, Z., Zhu, Y., Chen, J., & Li, W.
Affiliations
First Hospital of Jilin University (CN)
Corresponding author
Li, Wei
Venue
International Journal of Stem Cells
Published
2020-11-30
Volume
13
Issue
3
Pages
312-325
ISSN
  • 2005-3606 (ISSN-L)
  • 2005-5447
OpenAlex
W3080370859
Cited by
91
References
138
Citations by year
2026: 9 · 2025: 20 · 2024: 23 · 2023: 19 · 2022: 14 · 2021: 6
FWCI
1.05
Type
journal article
Language
en
Open access
Locations
  • International Journal of Stem Cells (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (2018YFA0106902, 81372835 and 81670143, #81372835, 81670143)
  • National Key Research and Development Program of China (2018YFA0106902, 81670143, 81372835)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
Oct4, cancer stem cells, transcription factors, self-renewal, tumor recurrence, metastasis, drug resistance, non-coding RNA, protein complexes, signaling pathways, therapeutic target

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