The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Cell Shape Dynamics in Escherichia coli
Open accessAbstract
Bacteria are the simplest living organisms. In particular, Escherichia coli has been extensively studied and it has become one of the standard model systems in microbiology. However, optical microscopy studies of single E. coli have been limited by its small size, approximately 1 x 3 microm, not much larger than the optical resolution, approximately 0.25 microm. As a result, not enough quantitative dynamical information on the life cycle of single E. coli is presently available. We suggest that, by careful analysis of images from phase contrast and fluorescence time-lapse microscopy, this limitation can be bypassed. For example, we show that applying this approach to monitoring morphogenesis in individual E. coli leads to a simple, quantitative description of this process. First, we find the time when the formation of the septum starts, tau(c). It occurs much earlier than the time when the constriction can be directly observed by phase contrast. Second, we find that the growth law of single cells is more likely bilinear/trilinear than exponential. This is further supported by the relations that hold between the corresponding growth rates. These methods could be further extended to study the dynamics of cell components, e.g., the nucleoid and the Z-ring.
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“Furthermore, the rapid self-proliferation of living cells increases the difficulty of estimating their exact concentrations15.”
From Label-Free Detection of Single Living Bacteria via Electrochemical Collision Event (2016) · cites this paper as [15]
Citations
Cites
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FtsZ in Bacterial Cytokinesis: Cytoskeleton and Force Generator All in One
Erickson, H., Anderson, D. E., & Osawa, M. (2010) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00021-10 · Cited by 646
Using buoyant mass to measure the growth of single cells
Godin, M., Delgado, F. F., Son, S., Grover, W. H., Bryan, A. K., Tzur, A., Jorgensen, P., Payer, K., Grossman, A. D., Kirschner, M. W., et al. (2010) · Nature Methods · doi:10.1038/nmeth.1452 · Cited by 394
Optical measurement of cycle-dependent cell growth
Mir, M., Wang, Z., Shen, Z. Z., Bednarz, M., Bashir, R., Golding, I., Prasanth, S. G., & Popescu, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100506108 · Cited by 411
Conventional and emerging detection techniques for pathogenic bacteria in food science: A review
Hameed, S. F., Xie, L., & Ying, Y. B. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.05.020 · Cited by 402
Mir, M., Bhaduri, B., Wang, R., Zhu, R., & Popescu, G. (2012) · Progress in optics · doi:10.1016/b978-0-44-459422-8.00003-5 · Cited by 246
Metadata
- Authors
- Reshes, G., Vanounou, S., Fishov, I., & Feingold, M.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- Corresponding author
- Fishov, Itzhak
- Venue
- Biophysical Journal
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 94
- Issue
- 1
- Pages
- 251-264
- ISSN
- 0006-3495 (ISSN-L)
- PMC
- PMC2134870
- OpenAlex
- W2025598949
- Cited by
- 226
- References
- 82
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 16 · 2023: 9 · 2022: 13 · 2021: 20 · 2020: 27 · 2019: 17 · 2018: 11 · 2017: 14 · 2016: 17 · 2015: 10 · 2014: 11 · 2013: 8 · 2012: 4
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biophysical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Israel Academy of Sciences and Humanities (820/05)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Keywords
- Escherichia coli, cell shape dynamics, bacterial morphogenesis, cell division, septum formation, cell constriction, single-cell imaging, time-lapse microscopy, phase contrast microscopy, fluorescence microscopy, Z-ring, nucleoid
- MeSH terms
- Computer Simulation, Escherichia coli, Image Interpretation, Computer-Assisted, Models, Biological, Cell Enlargement
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