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RADIOIMMUNOASSAY OF STEROIDS
Abstract
A number of radioimmunoassay systems have been developed for quantitation of a variety of steroid hormones. Suitable antisera were obtained by immunizing rabbits with steroid derivatives conjugated at various positions to bovine serum albumin. The specificity of the antisera varied directly with the position of conjugation. Changes in the latter resulted in greater than 2000-fold shifts in relative inhibitory activity for a given steroid. The data indicate that conjugation should be done through a region (such as position 6) that is remote from distinguishing functional groups. The specificity data and nature of the inhibition curves suggest that the major portion of the steroid molecule is being recognized as a single immunoreactive unit. The advantages and problems associated with use of radioiodinated conjugates for labeled steroids are discussed. With conjugates, it has been possible to quantitate reliably as little as one pg of some steroids in a single assay tube.
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Citations
Cited by
Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993
Inhibition of Adrenal Steroidogenesis by the Anesthetic Etomidate
Wagner, R. L., White, P. F., Kan, P. B., Rosenthal, M. H., & Feldman, D. (1984) · New England Journal of Medicine · doi:10.1056/nejm198405313102202 · Cited by 555
Biological and social contributions to negative affect in young adolescent girls
Brooks-Gunn, J., & Warren, M. P. (1989) · Child Development · doi:10.2307/1131069 · Cited by 359
Influence of testosterone on breathing during sleep
Schneider, B. K., Pickett, C. K., Zwillich, C. W., Weil, J. V., McDermott, M. T., Santen, R. J., Varano, L. A., & White, D. P. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.61.2.618 · Cited by 179
BIANCO, A. C., NUNES, M. T., HELL, N. S., & MACIEL, R. M. B. (1987) · Endocrinology · doi:10.1210/endo-120-3-1033 · Cited by 104
Metadata
- Authors
- Midgley, A. R., & Niswender, G. D.
- Venue
- Acta Endocrinologica
- Publisher
- Oxford University Press (OUP)
- Published
- 1970-12
- Volume
- 65
- Issue
- 1_Suppl
- Pages
- S320-S331
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2029370288
- Cited by
- 268
- References
- 0
- FWCI
- 9.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: RADIOIMMUNOASSAY OF STEROIDS. https://app.cochat.ai/papers/10.1530/acta.0.065s320
- The paper
- Midgley, A. R., & Niswender, G. D. (1970). RADIOIMMUNOASSAY OF STEROIDS. Acta Endocrinologica. https://doi.org/10.1530/acta.0.065s320
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
