Influence of testosterone on breathing during sleep
Abstract
Apneas and hypopneas during sleep occur more frequently in men than women. Disordered breathing is also reported to increase in hypogonadal men following testosterone administration. This suggests a hormonal influence on sleeping respiratory pattern. We therefore studied respiratory rhythm during sleep in 11 hypogonadal males both on and off testosterone-replacement therapy. In four subjects the anatomy (computerized tomography) and airflow resistance of the upper airway were also determined on both occasions. Sleep stage distribution and duration were unchanged following androgen administration. However, both apneas and hypopneas increased significantly during testosterone replacement so that the total number of disordered breathing events (apneas + hypopneas) per hour of sleep rose from 6.4 +/- 2.1 to 15.4 +/- 7.0 (P less than 0.05). This was a highly variable event with some subjects demonstrating large increases in apneas and hypopneas when androgen was replaced, whereas others had little change in respiration during sleep. Upper airway dimensions, on the other hand, were unaffected by testosterone. These results suggest that testosterone contributes to sleep-disordered breathing through mechanisms independent of anatomic changes in the upper airway.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Two randomized controlled trials show that testosterone therapy can acutely (within 2-3 weeks) induce sleep-disordered breathing.
“two randomized controlled trials show that testosterone therapy can acutely (within 2–3 weeks) induce sleep-disordered breathing [126, 127].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [126]
Cites
Guilleminault, C., Tilkian, A., & Dement, W. C. (1976) · Annual Review of Medicine · doi:10.1146/annurev.me.27.020176.002341 · Cited by 1,812 · see citing works
Interaction of sleep state and chemical stimuli in sustaining rhythmic ventilation
Skatrud, J. B., & Dempsey, J. A. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.3.813 · Cited by 349 · see citing works
Ventilatory Control in Myxedema and Hypothyroidism
Zwillich, C. W., Pierson, D. J., Hofeldt, F. D., Lufkin, E. G., & Weil, J. V. (1975) · New England Journal of Medicine · doi:10.1056/nejm197503272921302 · Cited by 292 · see citing works
Self-citationMIDGLEY, A. R., & NISWENDER, G. D. (1970) · European Journal of Endocrinology · doi:10.1530/acta.0.065s320 · Cited by 268 · see citing works
Obstructive Sleep Apnea Syndrome Induced by Testosterone Administration
Sandblom, R. E., Matsumoto, A. M., Schoene, R. B., Lee, K. A., Giblin, E. C., Bremner, W. J., & Pierson, D. J. (1983) · New England Journal of Medicine · doi:10.1056/nejm198303033080908 · Cited by 205 · see citing works
Pharyngeal resistance in normal humans: influence of gender, age, and obesity
White, D. P., Lombard, R. M., Cadieux, R. J., & Zwillich, C. W. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.58.2.365 · Cited by 183 · see citing works
Self-citationEffects of progesterone on chemosensitivity in normal men.
Cw, Z., Mr, N., Fd, S., & Weil, J. V. (1978) · PubMed · Cited by 178 · see citing works
Self-citationSleep-disordered breathing and nocturnal oxygen desaturation in postmenopausal women
Block, A. J., Wynne, J. W., & Boysen, P. G. (1980) · The American Journal of Medicine · doi:10.1016/0002-9343(80)90502-1 · Cited by 173 · see citing works
Pathogenesis of apneas in hypersomnia-sleep apnea syndrome.
Önal, E., Lopata, M., & O'Connor, T. (1982) · PubMed · doi:10.1164/arrd.1982.125.2.167 · Cited by 129 · see citing works
Kenyon, A. T., Knowlton, K., Sandiford, I., Koch, F. C., & Lotwin, G. (1940) · Endocrinology · doi:10.1210/endo-26-1-26 · Cited by 125 · see citing works
Progesterone Therapy in Obese Patients With Sleep Apnea
Orr, W. C. (1979) · Archives of Internal Medicine · doi:10.1001/archinte.1979.03630380087030 · Cited by 124 · see citing works
Influence of testosterone on ventilation and chemosensitivity in male subjects
White, D. P., Schneider, B. K., Santen, R. J., McDermott, M., Pickett, C. K., Zwillich, C. W., & Weil, J. V. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.59.5.1452 · Cited by 104 · see citing works
Self-citationEffects of Hypermetabolism on Ventilation and Chemosensitivity
Zwillich, C. W., Sahn, S. A., & Weil, J. V. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108844 · Cited by 89 · see citing works
Self-citationInduction of the obstructive sleep apnea syndrome in a woman by exogenous androgen administration.
Johnson, M. W., Anch, A. M., & Remmers, J. E. (1984) · PubMed · doi:10.1164/arrd.1984.129.6.1023 · Cited by 78 · see citing works
Cherniack, N. S. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111355 · Cited by 78 · see citing works
Sleep-Disordered Breathing and Oxygen Desaturation in Obese Patients
Harman, E. M., Wynne, J. W., Block, A. J., & Malloy-Fisher, L. (1981) · CHEST Journal · doi:10.1378/chest.79.3.256 · Cited by 61 · see citing works
Thompson, W. O., & Heckel, N. J. (1939) · JAMA · doi:10.1001/jama.1939.02800490020005 · Cited by 20 · see citing works
Hypoxic Versus Hypocapnic Effects on Periodic Breathing During Sleep
Berssenbrugge, A. D., Dempsey, J. A., & Skatrud, J. B. (1984) · Springer eBooks · doi:10.1007/978-1-4614-7525-5_11 · Cited by 14 · see citing works
KROHN, P. L. (1949) · BMJ · doi:10.1136/bmj.2.4618.61 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Prevalence of Sleep-disordered Breathing in Women
BIXLER, E. O., VGONTZAS, A. N., LIN, H.-M., TEN HAVE, T., REIN, J., VELA-BUENO, A., & KALES, A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.3.9911064 · Cited by 1,598 · see citing works
Pathophysiology of Adult Obstructive Sleep Apnea
Eckert, D. J., & Malhotra, A. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200707-114mg · Cited by 719 · see citing works
Risks of testosterone-replacement therapy and recommendations for monitoring.
Rhoden, E. L., & Morgentaler, A. (2004) · New England Journal of Medicine · doi:10.1056/nejmra022251 · Cited by 705 · see citing works
Sex differences in sleep: impact of biological sex and sex steroids
Mong, J. A., & Cusmano, D. M. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0110 · Cited by 578 · see citing works
Andropause: clinical implications of the decline in serum testosterone levels with aging in men
Matsumoto, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.2.m76 · Cited by 490 · see citing works
The Male Predisposition to Pharyngeal Collapse: Importance of Airway Length
Malhotra, A., Huang, Y., Fogel, R. B., Pillar, G., Edwards, J. K., Kikinis, R., Loring, S. H., & White, D. P. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2112072 · Cited by 441 · see citing works
Self-citationEpidemiology, Risk Factors, and Consequences of Obstructive Sleep Apnea and Short Sleep Duration
Lawati, N. M. A., Patel, S. R., & Ayas, N. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.08.001 · Cited by 413 · see citing works
Upper airway muscle activity in normal women: influence of hormonal status
Popovic, R. M., & White, D. P. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.3.1055 · Cited by 377 · see citing works
Self-citationThe benefits and risks of testosterone replacement therapy: a review
Morley, J. E. (2009) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s3025 · Cited by 375 · see citing works
Optimal management of sarcopenia
Sumukadas, D. (2010) · Clinical Interventions in Aging · doi:10.2147/cia.s11473 · Cited by 303 · see citing works
Neuroendocrine Dysfunction in Sleep Apnea: Reversal by Continuous Positive Airways Pressure Therapy*
GRUNSTEIN, R. R., HANDELSMAN, D. J., LAWRENCE, S. J., BLACKWELL, C., CATERSON, I. D., & SULLIVAN, C. E. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-2-352 · Cited by 302 · see citing works
The Short-Term Effects of High-Dose Testosterone on Sleep, Breathing, and Function in Older Men
Liu, P. Y., Yee, B., Wishart, S. M., Jimenez, M., Jung, D. G., Grunstein, R. R., & Handelsman, D. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030236 · Cited by 275 · see citing works
Fogel, R. B., Malhotra, A., Pillar, G., Pittman, S. D., Dunaif, A., & White, D. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7316 · Cited by 274 · see citing works
Self-citationEndocrine Aspects of Obstructive Sleep Apnea
Attal, P. D., & Chanson, P. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1912 · Cited by 256 · see citing works
Central neural mechanisms of progesterone action: application to the respiratory system
Bayliss, D. A., & Millhorn, D. E. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.2.393 · Cited by 235 · see citing works
Leptin, obesity, and respiratory function
O'Donnell, C. P., Tankersley, C. G., Polotsky, V. P., Schwartz, A. R., & Smith, P. L. (2000) · Respiration Physiology · doi:10.1016/s0034-5687(99)00111-5 · Cited by 233 · see citing works
Davies, S., Papp, V., & Antoni, C. (2015) · International Journal of Transgenderism · doi:10.1080/15532739.2015.1075931 · Cited by 193 · see citing works
Obstructive Sleep Apnea in Adults: Epidemiology, Clinical Presentation, and Treatment Options
Lurie, A. (2011) · Advances in cardiology · doi:10.1159/000327660 · Cited by 200 · see citing works
Saaresranta, T., & Polo, O. J. (2002) · CHEST Journal · doi:10.1378/chest.122.6.2165 · Cited by 198 · see citing works
Obesity and testicular function
Mah, P., & Wittert, G. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.06.007 · Cited by 179 · see citing works
Influence of Gender on Waking Genioglossal Electromyogram and Upper Airway Resistance
Popovic, R. M., & White, D. P. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.2.7633734 · Cited by 163 · see citing works
Self-citationUnderstanding dyspnea as a complex individual experience
Hayen, A., Herigstad, M., & Pattinson, K. T. S. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.06.005 · Cited by 161 · see citing works
Sex steroid hormones and the neural control of breathing
Behan, M., Zabka, A. G., Thomas, C. F., & Mitchell, G. S. (2003) · Respiratory Physiology & Neurobiology · doi:10.1016/s1569-9048(03)00086-7 · Cited by 161 · see citing works
Barrett-Connor, E., Dam, T.-T., Stone, K., Harrison, S. L., Redline, S., Orwoll, E., & for the Osteoporotic Fractures in Men Study Group (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2622 · Cited by 158 · see citing works
Surampudi, P. N., Wang, C., & Swerdloff, R. S. (2012) · International Journal of Endocrinology · doi:10.1155/2012/625434 · Cited by 151 · see citing works
Gender and Obstructive Sleep Apnea Syndrome, Part 2: Mechanisms
Kapsimalis, F., & Kryger, M. H. (2002) · SLEEP · doi:10.1093/sleep/25.5.497 · Cited by 146 · see citing works
Gopal, M., Duntley, S. P., Uhles, M., & Attarian, H. P. (2002) · Sleep Medicine · doi:10.1016/s1389-9457(02)00033-3 · Cited by 141 · see citing works
Testosterone Supplementation in Older Men: A Rational Idea Whose Time Has Not Yet Come
Bhasin, S., & Buckwalter, J. G. (2001) · Journal of Andrology · doi:10.1002/j.1939-4640.2001.tb02570.x · Cited by 136 · see citing works
The interrelationships between thyroid dysfunction and hypogonadism in men and boys
Meikle, A. W. (2004) · Thyroid · doi:10.1089/105072504323024552 · Cited by 128 · see citing works
Sleep, Sleep Disorders, and Sexual Dysfunction
Cho, J. W., & Duffy, J. F. (2018) · The World Journal of Men s Health · doi:10.5534/wjmh.180045 · Cited by 131 · see citing works
Gambineri, A., Pelusi, C., & Pasquali, R. (2003) · Journal of Endocrinological Investigation · doi:10.1007/bf03345209 · Cited by 113 · see citing works
Hormonal Therapy of Male Hypogonadism
Matsumoto, A. M. (1994) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30072-0 · Cited by 112 · see citing works
Sleep disorders in the elderly
Phillips, B. A., & Ancoli‐Israel, S. (2001) · Sleep Medicine · doi:10.1016/s1389-9457(00)00083-6 · Cited by 108 · see citing works
Lunenfeld, B., Saad, F., & Hoesl, C. E. (2005) · The Aging Male · doi:10.1080/13685530500163416 · Cited by 108 · see citing works
Drinka, P. J., Jochen, A., Cuisinier, M. C., Bloom, R. J., Rudman, I. W., & Rudman, D. R. (1995) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb05534.x · Cited by 105 · see citing works
Endocrine Therapy of Transsexualism and Potential Complications of Long-Term Treatment
Futterweit, W. (1998) · Archives of Sexual Behavior · doi:10.1023/a:1018638715498 · Cited by 97 · see citing works
Testosterone replacement therapy: for whom, when and how?
Tsametis, C. P., & Isidori, A. M. (2018) · Metabolism · doi:10.1016/j.metabol.2018.03.007 · Cited by 96 · see citing works
Sleep-related erections: Clinical perspectives and neural mechanisms
Hirshkowitz, M., & Schmidt, M. H. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.03.001 · Cited by 88 · see citing works
Gargaglioni, L., Marques, D. A., & Patrone, L. G. (2019) · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · doi:10.1016/j.cbpa.2019.110543 · Cited by 71 · see citing works
McNamara, S. G., Grunstein, R. R., & Sullivan, C. E. (1993) · Thorax · doi:10.1136/thx.48.7.754 · Cited by 87 · see citing works
Developmental changes in response to subatmospheric pressure loading of the upper airway
Marcus, C. L., Lutz, J., Hamer, A., Smith, P. L., & Schwartz, A. R. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.2.626 · Cited by 85 · see citing works
Nickol, A. H., Leverment, J., RICHARDS, P., Seal, P. F., HARRIS, G. A., CLELAND, J., Dubowitz, G., Collier, D., Milledge, J. S., Stradling, J. R., et al. (2006) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2006.00558.x · Cited by 84 · see citing works
Interactions between obstructive sleep apnea and the metabolic syndrome
Svatikova, A., Wolk, R. A., Gami, A. S., Pohanka, M., & Somers, V. K. (2005) · Current Diabetes Reports · doi:10.1007/s11892-005-0068-2 · Cited by 85 · see citing works
Testosterone Therapy and Obstructive Sleep Apnea: Is There a Real Connection?
Hanafy, H. M. (2007) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2007.00553.x · Cited by 84 · see citing works
Testicular Dysfunction in Systemic Disease
Handelsman, D. J. (1994) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30071-9 · Cited by 84 · see citing works
Sleep, testosterone and cortisol balance, and ageing men
Liu, P. Y., & Reddy, R. T. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09755-4 · Cited by 80 · see citing works
“The issue of testosterone effects on OSA should not be ignored because two randomized controlled trials show that testosterone therapy can acutely (within 2–3 weeks) induce sleep-disordered breathing [126, 127].”
BackgroundNeuroendocrine alterations in obese patients with sleep apnea syndrome
Lanfranco, F., Motta, G., Minetto, M. A., Baldi, M., Balbo, M., Ghigo, E., Arvat, E., & Maccario, M. (2010) · International Journal of Endocrinology · doi:10.1155/2010/474518 · Cited by 78 · see citing works
Sleep Disorders and Medical Conditions in Women
Phillips, B. A., Collop, N. A., Drake, C. L., Consens, F. B., Vgontzas, A. N., & Weaver, T. E. (2008) · Journal of Women s Health · doi:10.1089/jwh.2007.0561 · Cited by 76 · see citing works
Obstructive Sleep Apnea and Testosterone Deficiency
Kim, S.-D., & Cho, K.-S. (2018) · The World Journal of Men's Health · doi:10.5534/wjmh.180017 · Cited by 57 · see citing works
Killick, R., Wang, D., Hoyos, C., Yee, B., Grunstein, R. R., & Liu, P. Y. (2013) · Journal of Sleep Research · doi:10.1111/jsr.12027 · Cited by 74 · see citing works
Stewart, D. A., Grunstein, R. R., Berthon-Jones, M., Handelsman, D. J., & Sullivan, C. E. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.6.1389 · Cited by 74 · see citing works
Sleep Disturbances Across a Woman's Lifespan: What Is the Role of Reproductive Hormones?
Haufe, A., & Leeners, B. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad036 · Cited by 84 · see citing works
Clinical Practice Manual for Late‐onset Hypogonadism Syndrome
Namiki, M., Akaza, H., Shimazui, T., Ito, N., Iwamoto, T., Baba, K., Kumano, H., Koh, E., Tsujimura, A., Matsumiya, K., et al. (2008) · International Journal of Urology · doi:10.1111/j.1442-2042.2008.02010.x · Cited by 71 · see citing works
Salivary testosterone concentration of Aymara men native to 3600 m
Beall, C. M., Worthman, C. M., Stallings, J. F., Strohl, K. P., Brittenham, G. M., & Barragan, M. (1992) · Annals of Human Biology · doi:10.1080/03014469200001932 · Cited by 71 · see citing works
Influence of physiological androgen levels on wound healing and immune status in men
Fimmel, S., & Zouboulis, C. C. (2005) · The Aging Male · doi:10.1080/13685530500233847 · Cited by 70 · see citing works
Cusmano, D. M., Hadjimarkou, M. M., & Mong, J. A. (2013) · Endocrinology · doi:10.1210/en.2013-1624 · Cited by 70 · see citing works
An integrative review on current evidence of testosterone replacement therapy for the andropause
Tan, R. S., & Culberson, J. W. (2003) · Maturitas · doi:10.1016/s0378-5122(03)00083-5 · Cited by 70 · see citing works
Sex differences in sleep disordered breathing in adults.
Lozo, T., Komnenov, D., Badr, M. S., & Mateika, J. (2017) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2016.11.001 · Cited by 63 · see citing works
Sleep disorders in the elderly
Shochat, T., Loredo, J. S., & Ancoli‐Israel, S. (2001) · Current Treatment Options in Neurology · doi:10.1007/s11940-001-0021-x · Cited by 64 · see citing works
Sleep-disordered breathing and hormones
Saaresranta, T., & Polo, O. J. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00062403 · Cited by 66 · see citing works
Influence of Sex on Sleep Regulatory Mechanisms
Paul, K. N., Turek, F. W., & Kryger, M. H. (2008) · Journal of Women's Health · doi:10.1089/jwh.2008.0841 · Cited by 63 · see citing works
Treatment of Obstructive Sleep Apnea
Hudgel, D. W. (1996) · CHEST Journal · doi:10.1378/chest.109.5.1346 · Cited by 63 · see citing works
Obstructive Sleep Apnea Due to Endogenous Testosterone Production in a Woman
Dexter, D., & Dovre, E. J. (1998) · Mayo Clinic Proceedings · doi:10.4065/73.3.246 · Cited by 63 · see citing works
Ventilatory Responses During Wakefulness In Children With Obstructive Sleep Apnea
Marcus, C. L., Gozal, D., Arens, R., Basinski, D. J., Omlin, K. J., Keens, T. G., & Ward, S. L. D. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.3.8118641 · Cited by 62 · see citing works
Endocrinologic Treatment of Gender Identity Disorders
Tangpricha, V., Ducharme, S. H., Barber, T. W., & Chipkin, S. R. (2003) · Endocrine Practice · doi:10.4158/ep.9.1.12 · Cited by 60 · see citing works
Liu, P. Y. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00683 · Cited by 55 · see citing works
Sleep Apnea Syndrome in Endocrine Diseases
Bottini, P., & Tantucci, C. (2003) · Respiration · doi:10.1159/000072019 · Cited by 52 · see citing works
Impact of concomitant medications on obstructive sleep apnoea
Jullian‐Desayes, I., Revol, B., Chareyre, E., Camus, P., Villier, C., Borel, J., Pépin, J., & Joyeux‐Faure, M. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13153 · Cited by 53 · see citing works
Ioachimescu, O. C., & Collop, N. A. (2012) · Neurologic Clinics · doi:10.1016/j.ncl.2012.08.003 · Cited by 50 · see citing works
Androgen deficiency in the aging male: benefits and risks of androgen supplementation
Gooren, L. J. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00206-1 · Cited by 49 · see citing works
Androgens, Obesity, and Sleep-Disordered Breathing in Men
Liu, P. Y., Caterson, I. D., Grunstein, R. R., & Handelsman, D. J. (2007) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2007.03.002 · Cited by 43 · see citing works
Aortic Root Dilatation in Marfan's Syndrome
Cistulli, P. A., Wilcox, I., Sullivan, C. E., & Jeremy, R. (1997) · CHEST Journal · doi:10.1378/chest.111.6.1763 · Cited by 42 · see citing works
Pharmacological treatment of sleep apnea: Current situation and future strategies
Hedner, J. A., Grote, L., & Zou, D. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.06.002 · Cited by 42 · see citing works
MECHANISMS OF ENDOCRINOLOGY: Mechanisms of disease: the endocrinology of obstructive sleep apnoea
Lavrentaki, A., Ali, A., Cooper, B. G., & Tahrani, A. A. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0411 · Cited by 44 · see citing works
Carneiro, G., Florio, R., Zanella, M. T., Pradella-Hallinan, M. L. D. C., Ribeiro‐Filho, F. F., Tufik, S., & Togeiro, S. M. (2011) · Sleep And Breathing · doi:10.1007/s11325-010-0468-7 · Cited by 39 · see citing works
Butterfield, K. J., Marks, P., McLean, L., & Newton, J. (2014) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2014.11.016 · Cited by 38 · see citing works
Neuroendocrine changes in sleep apnea
Yee, B. J., Liu, P. X., Phillips, C. L., & Grunstein, R. R. (2004) · Current Opinion in Pulmonary Medicine · doi:10.1097/01.mcp.0000143967.34079.27 · Cited by 33 · see citing works
Rationale for anabolic therapy to facilitate rehabilitation in chronic obstructive pulmonary disease
Casaburi, R. H. (1998) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(98)80134-1 · Cited by 34 · see citing works
Testosterone administration in older men
Matsumoto, A. M. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.02.011 · Cited by 32 · see citing works
Age-Related Changes in Male Gonadal Function
Maas, D. L., Jochen, A., & Lalande, B. M. (1997) · Drugs & Aging · doi:10.2165/00002512-199711010-00005 · Cited by 32 · see citing works
Celec, P., Mucska, I., Ostatníková, D., & Hodosy, J. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-013-0003-3 · Cited by 33 · see citing works
Review of health risks of low testosterone and testosterone administration
Jia, H. (2015) · World Journal of Clinical Cases · doi:10.12998/wjcc.v3.i4.338 · Cited by 33 · see citing works
Ahuja, D., Mateika, J. H., Diamond, M. P., & Badr, M. S. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01178.2006 · Cited by 30 · see citing works
O'Donnell, C. P., Schwartz, A. R., & Smith, P. L. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.5.ed11-00b · Cited by 31 · see citing works
Current and future testosterone delivery systems for treatment of the hypogonadal male
Pfeil, E., & Dobs, A. S. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.4.471 · Cited by 30 · see citing works
Androgen replacement therapy in the aging male.
Myers, J. B., & Meacham, R. B. (2003) · Europe PMC (PubMed Central) · Cited by 30 · see citing works
Puberty and Upper Airway Dynamics During Sleep
Bandla, P., Huang, J., Karamessinis, L. R., Kelly, A. T., Pepe, M. E., Samuel, J. M., Brooks, L. J., Mason, T. A., Gallagher, P. R., & Marcus, C. L. (2008) · SLEEP · doi:10.1093/sleep/31.4.534 · Cited by 30 · see citing works
Venâncio, D. P., Tufik, S., Garbuio, S. A., da Nóbrega, A. C. L., & de Mello, M. T. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0621-6 · Cited by 30 · see citing works
Prevalence and severity of sleep disordered breathing in a group of morbidly obese patients
van Boxem, T. J. (1999) · The Netherlands Journal of Medicine · doi:10.1016/s0300-2977(98)00139-9 · Cited by 29 · see citing works
Testosterone therapy in men: Clinical and pharmacological perspectives
Gambineri, A., & Pasquali, R. (2000) · Journal of Endocrinological Investigation · doi:10.1007/bf03343707 · Cited by 28 · see citing works
Obstructive Sleep Apnea and Testosterone Therapy.
Payne, K. S., Lipshultz, L., Hotaling, J., & Pastuszak, A. (2020) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2020.04.004 · Cited by 20 · see citing works
Clinical Manifestations and Consequences of Obstructive Sleep Apnea
Wenner, J. B., Cheema, R., & Ayas, N. (2009) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0b013e31819a00f1 · Cited by 25 · see citing works
Gonzales, G. F., & Villena, A. (2000) · International Journal of Gynecology & Obstetrics · doi:10.1016/s0020-7292(00)00270-8 · Cited by 24 · see citing works
Sleep Disorders and Upper Airway Obstruction in Adults
Westbrook, P. R. (1990) · Otolaryngologic Clinics of North America · doi:10.1016/s0030-6665(20)31248-2 · Cited by 24 · see citing works
Is sleep apnea a predisposing factor for tobacco use?
Schrand, J. R. (1996) · Medical Hypotheses · doi:10.1016/s0306-9877(96)90155-3 · Cited by 23 · see citing works
Erectile Dysfunction and Obstructive Sleep Apnea: A Review
Gu, Y., Wu, C., Qin, F., & Yuan, J. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.766639 · Cited by 23 · see citing works
Hassan, J., & Barkin, J. (2016) · PubMed · Cited by 21 · see citing works
Souza, G. M. P. R., Amorim, M. R., Moraes, D. J. A., & Machado, B. H. (2017) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2017.09.003 · Cited by 21 · see citing works
Testosterone Deficiency and Sleep Apnea
Burschtin, O. E., & Wang, J. (2016) · Urologic Clinics of North America · doi:10.1016/j.ucl.2016.01.012 · Cited by 21 · see citing works
Morselli, L., Temple, K. A., Leproult, R., Ehrmann, D., Cauter, E. V., & Mokhlesi, B. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00377 · Cited by 20 · see citing works
- Authors
- Schneider, B. K., Pickett, C. K., Zwillich, C. W., Weil, J. V., McDermott, M. T., Santen, R. J., Varano, L. A., & White, D. P.
- ORCID
- Santen, R. J.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1986-08-01
- Volume
- 61
- Issue
- 2
- Pages
- 618-623
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W1929790158
- Cited by
- 179
- References
- 19
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 2 · 2014: 4 · 2013: 8 · 2012: 5
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG04491)
- National Heart, Lung, and Blood Institute (HL-01316)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- testosterone, sleep-disordered breathing, apnea, hypopnea, hypogonadism, testosterone replacement therapy, androgens, upper airway resistance, upper airway anatomy, respiratory rhythm, sex differences
- MeSH terms
- Arousal, Humans, Hypogonadism, Male, Middle Aged, Respiration, Sleep, Sleep Apnea Syndromes, Testosterone
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
