Urinary melatonin, LH, oestradiol, progesterone excretion during the menstrual cycle or in women taking oral contraceptives
Abstract
Abstract. Nocturnal urinary excretion of melatonin, LH, progesterone and oestradiol was measured by radioimmunoassay in nine normal women during a complete cycle. In addition, these hormonal excretions were studied in two women taking an oral contraceptive. A high within-subject coefficient of variation was observed for melatonin excretion in the two groups. In the nine normal cycling women, melatonin excretion was not decreased at the time of ovulation, but was significantly increased during the luteal phase compared with that of the follicular phase (P < 0.01). These data are consistent with a positive relationship between melatonin and progesterone during the luteal phase. In the two women under an oral contraceptive, melatonin excretion was found within the same range as for the other nine. The results are discussed in terms of pineal investigation in human.
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Nocturnal urinary immunoreactive melatonin concentration was significantly increased during the luteal phase compared with the follicular phase.
“This result was supported by the finding that nocturnal urinary immunoreactive melatonin concentration (sampled nightly over an entire menstrual cycle) was significantly increased during the LP compared to the FP [59].”
From Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder (2010) · cites this paper as [59]
Exogenous synthetic progestins in the form of oral contraceptives tend to increase melatonin secretion.
“Exogenous synthetic progestins (in the form of oral contraceptives) have a tendency to increase melatonin secretion [58, 59, 67]”
From Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder (2010) · cites this paper as [59]
Variable results including both increases and decreases in melatonin and changes in the timing of hormones have been described.
“Generally, circadian hormone rhythms are not significantly altered across the menstrual cycle (see Table 2), though variable results including both increases [58, 59] and decreases [37] in melatonin as well as changes in the timing of hormones [35] have been described.”
From Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder (2010) · cites this paper as [59]
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“Prior reports have suggested that melatonin levels in the luteal phase are increased (Brun et al., 1987; Webley and Leidenberger, 1986; Wetterberg et al., 1976), decreased (Shibui et al., 2000), or unchanged (Berga and Yen, 1990; Brzezinski et al., 1988; Delfs et al., 1994; Ito et al., 1993; Parry…”
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“contraceptives [54-56].”
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“We determined both melatonin and aMT6S with radioimmunoassays previously described [11, 12].”
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“Studies investigating the melatonin rhythm during the menstrual cycle have also provided conflicting results, with some studies reporting increased melatonin levels in the luteal phase (Wetterberg et al., 1976; Webley et al., 1986; Brun et al., 1987), decreased melatonin amplitude during the luteal phase (Shibui et al.”
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“In addition, a study showed that progesterone receptors are present in the bovine pineal gland, which may support the melatonin-progesterone interaction in regulating the menstrual cycles (8, 9, 11, 23, 24).”
Background
- Authors
- Brun, J., Claustrat, B., & David, M.
- Affiliations
- Hospices Civils de Lyon (FR)
- Corresponding author
- Claustrat, Bruno
- ORCID
- Claustrat, Bruno
- Venue
- Acta Endocrinologica
- Publisher
- Oxford University Press (OUP)
- Published
- 1987-09
- Volume
- 116
- Issue
- 1
- Pages
- 145-149
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2087806348
- Cited by
- 49
- References
- 0
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2014: 3 · 2013: 5 · 2012: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- urinary melatonin, luteinizing hormone, estradiol, progesterone, menstrual cycle, luteal phase, follicular phase, oral contraceptives, pineal gland
- MeSH terms
- Adult, Circadian Rhythm, Contraceptives, Postcoital, Contraceptives, Postcoital, Synthetic, Estradiol, Ethinyl Estradiol, Female, Humans, Luteinizing Hormone, Melatonin, Menstruation, Norgestrel, Progesterone, Ethinyl Estradiol-Norgestrel Combination
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