Effects of fasting on blood plasma levels, metabolism and metabolic effects of epinephrine and norepinephrine in steers
Abstract
Experiments were designed to study effects of 3 days of fasting on blood plasma levels, metabolic clearance rates (MCR) and effects of norepinephrine (NE) and epinephrine (E) on levels of glucose, nonesterified fatty acids (NEFA) and immunoreactive insulin (IRI) in 12 steers. During fasting, levels of E, NE and protein did not change, whereas IRI, T3 and glucose decreased and NEFA, acetoacetate and beta-hydroxybutyrate increased. Before and at the end of fasting, NE or E were iv infused for 120 min. NE and E were elevated after 15 min and to the end of the infusion. The increase in E, but not in NE, was significantly greater after 3 days of fasting than before fasting (P less than 0.05). MCR for E was lower after fasting (299 +/- 17 vs 204 +/- 10 ml.kg-0.75.min-1; P less than 0.001), whereas MCR for NE was not significantly different (455 +/- 37 vs 400 +/- 27 ml.kg-0.75.min-1). MCR was higher for NE than for E, both before and after fasting (P less than 0.05). After the infusion, E and NE decreased within minutes to pre-infusion concentrations. During E infusions, NEFA increased significantly more, whereas glucose increased less in fasted than in fed animals. During NE infusions, NEFA increased in fasted, but not in fed animals, and glucose increased less at the end than before fasting. IRI decreased during E infusions only in fed animals, and transiently increased after the infusion, except after NE infusion in fasted steers.(ABSTRACT TRUNCATED AT 250 WORDS)
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Transportation coupled with fasting is expected to result in an increase in the concentrations of BHBA and NEFA.
“so transportation coupled with fasting is expected to result in an increase in the concentrations of BHBA and NEFA”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Fröhli and Blum, 1988
Environmental challenges are the primary cause of fat mobilization in young calves.
“Environmental challenges (e.g., external events that calves are subjected to) are the primary cause of fat mobilization in young calves”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Fröhli and Blum, 1988
The transportation process includes an environmental challenge coupled with fasting which results in fat mobilization as indicated by energy markers, such as NEFA and BHB.
“The transportation process includes an environmental challenge coupled with fasting which results in fat mobilization as indicated by energy markers, such as NEFA and BHB (Fröhli and Blum, 1988).”
From A randomized controlled trial evaluating the effect of providing a rest period during long-distance transportation of surplus dairy calves: Part II. Effect on hematological variables (2024) · cites this paper as Fröhli and Blum, 1988
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- Authors
- Fröhli, D., & Blum, J. W.
- Affiliations
- ETH Zurich (CH)
- Venue
- Acta Endocrinologica
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-06
- Volume
- 118
- Issue
- 2
- Pages
- 254-259
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2081499679
- Cited by
- 29
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2012: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- F. Hoffmann-La Roche
- Topics
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Ruminant Nutrition and Digestive Physiology
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- fasting, epinephrine, norepinephrine, metabolic clearance rate, steers, free fatty acids, glucose, immunoreactive insulin, ketone bodies, thyroid hormones, plasma catecholamines, lipid mobilization
- MeSH terms
- Acetoacetates, Animals, Blood Glucose, Butyrates, Cattle, Epinephrine, Fasting, Fatty Acids, Nonesterified, Insulin, Male, Norepinephrine, Triiodothyronine
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