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Studies on the occurrence of ophthalmopathy in Graves' disease

Marcocci, C., Bartalena, L., Bogazzi, F., Panicucci, M., Pinchera, A.·1989·Acta Endocrinologica

Abstract

Abstract. Eye disease was associated with hyperthyroidism in 202 of 221 patients with active Graves' ophthalmopathy (91.4%) and was not accompanied by thyroid hyperfunction (euthyroid Graves' disease) in the remaining 19 (8.6%). All the latter patients had some mild thyroid abnormalities (thyroid autoantibodies, negative TRH test, negative T 3 suppression test, goitre). Sex distribution analysis evidenced a higher prevalence in females with a female/male ratio of 2.1 which was, however, significantly lower (P < 0.05) than that observed in control (Graves' disease patients without overt ophthalmopathy (female/male ratio = 3.4)). Patients with euthyroid Graves' disease showed a female/male ratio of 0.7. Age distribution revealed a peak prevalence in the 5th decade of life, identical to that of Graves' disease without ophthalmopathy. A close temporal relationship between the onset of hyperthyroidism and the onset of ophthalmopathy was found, since in about 85% of the patients the first ocular manifestations occurred within ±18 months around the onset of hyperthyroidism.

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Metadata

Authors
Marcocci, C., Bartalena, L., Bogazzi, F., Panicucci, M., & Pinchera, A.
Venue
Acta Endocrinologica
Published
1989-04
Volume
120
Issue
4
Pages
473-478
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
OpenAlex
W2043167901
Cited by
172
References
0
FWCI
3.86
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Studies on the occurrence of ophthalmopathy in Graves' disease. https://app.cochat.ai/papers/10.1530/acta.0.1200473
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Marcocci, C., Bartalena, L., Bogazzi, F., Panicucci, M., & Pinchera, A. (1989). Studies on the occurrence of ophthalmopathy in Graves' disease. Acta Endocrinologica. https://doi.org/10.1530/acta.0.1200473

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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