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Studies on the occurrence of ophthalmopathy in Graves' disease
Abstract
Abstract. Eye disease was associated with hyperthyroidism in 202 of 221 patients with active Graves' ophthalmopathy (91.4%) and was not accompanied by thyroid hyperfunction (euthyroid Graves' disease) in the remaining 19 (8.6%). All the latter patients had some mild thyroid abnormalities (thyroid autoantibodies, negative TRH test, negative T 3 suppression test, goitre). Sex distribution analysis evidenced a higher prevalence in females with a female/male ratio of 2.1 which was, however, significantly lower (P < 0.05) than that observed in control (Graves' disease patients without overt ophthalmopathy (female/male ratio = 3.4)). Patients with euthyroid Graves' disease showed a female/male ratio of 0.7. Age distribution revealed a peak prevalence in the 5th decade of life, identical to that of Graves' disease without ophthalmopathy. A close temporal relationship between the onset of hyperthyroidism and the onset of ophthalmopathy was found, since in about 85% of the patients the first ocular manifestations occurred within ±18 months around the onset of hyperthyroidism.
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Citations
Cited by
Management of Graves’ Ophthalmopathy: Reality and Perspectives*
Bartalena, L., Pinchera, A., & Marcocci, C. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0393 · Cited by 677
Self-citationCurrent Perspective on the Pathogenesis of Graves’ Disease and Ophthalmopathy
Prabhakar, B. S., Bahn, R. S., & Smith, T. J. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0020 · Cited by 489
Epidemiology and Prevention of Graves' Ophthalmopathy
Wiersinga, W. M., & Bartalena, L. (2002) · Thyroid · doi:10.1089/105072502761016476 · Cited by 458
Self-citationEpidemiology, Natural History, Risk Factors, and Prevention of Graves’ Orbitopathy
Bartalena, L., Piantanida, E., Gallo, D., Lai, A., & Tanda, M. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.615993 · Cited by 369
Self-citationBartalena, L., Marcocci, C., Bogazzi, F., Panicucci, M., Lepri, A., & Pinchera, A. (1989) · New England Journal of Medicine · doi:10.1056/nejm198911163212001 · Cited by 318
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Metadata
- Authors
- Marcocci, C., Bartalena, L., Bogazzi, F., Panicucci, M., & Pinchera, A.
- Venue
- Acta Endocrinologica
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-04
- Volume
- 120
- Issue
- 4
- Pages
- 473-478
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2043167901
- Cited by
- 172
- References
- 0
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Marcocci, C., Bartalena, L., Bogazzi, F., Panicucci, M., & Pinchera, A. (1989). Studies on the occurrence of ophthalmopathy in Graves' disease. Acta Endocrinologica. https://doi.org/10.1530/acta.0.1200473
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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