The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Bilateral inferior petrosal sinus sampling
Open accessAbstract
Simultaneous bilateral inferior petrosal sinus sampling (BIPSS) plays a crucial role in the diagnostic work-up of Cushing’s syndrome. It is the most accurate procedure in the differential diagnosis of hypercortisolism of pituitary or ectopic origin, as compared with clinical, biochemical and imaging analyses, with a sensitivity and specificity of 88–100% and 67–100%, respectively. In the setting of hypercortisolemia, ACTH levels obtained from venous drainage of the pituitary are expected to be higher than the levels of peripheral blood, thus suggesting pituitary ACTH excess as the cause of hypercortisolism. Direct stimulation of the pituitary corticotroph with corticotrophin-releasing hormone enhances the sensitivity of the procedure. The procedure must be undertaken in the presence of hypercortisolemia, which suppresses both the basal and stimulated secretory activity of normal corticotrophic cells: ACTH measured in the sinus is, therefore, the result of the secretory activity of the tumor tissue. The poor accuracy in lateralization of BIPSS (positive predictive value of 50–70%) makes interpetrosal ACTH gradient alone not sufficient for the localization of the tumor. An accurate exploration of the gland is recommended if a tumor is not found in the predicted area. Despite the fact that BIPSS is an invasive procedure, the occurrence of adverse events is extremely rare, particularly if it is performed by experienced operators in referral centres.
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“Sensitivity can be increased by obtaining ACTH levels under CRH stimulation (1, 76, 78).”
From Approach to the Patient: Diagnosis of Cushing Syndrome (2022) · cites this paper as [78]
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Cites
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Items 101–113 of 113
Parro, I. M., Ortiz-Sánchez, D., Moreno, R. G. G., Gómez-Rioja, R., Martínez, R. F., & Álvarez-Escolá, C. (2022) · Advances in Laboratory Medicine · doi:10.1515/almed-2022-0039
“El CCSSPPII se ha consolidado en múltiples series de casos comométodo de referencia para diferenciar entre EC y CE [3, 8, 10, 12, 15].”
BackgroundInfluentialParaneoplastisch syndroom van Cushing
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Comment je fais un prélèvement veineux par cathétérisme des sinus pétreux inférieurs ?
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Ectopic Acth-Producing Pulmonary Carcinoid: A Rare Case of Simulating the Cushing’s disease
Nakhjavan, M. (2020) · Journal of Clinical Research and Reports · doi:10.31579/2690-1919/044
“Also, the pituitary MRI showed a microadenoma with a size less than 6mm (figure1).”
BackgroundInfluentialPediatric Cushing disease: Desmopressin versus ovine CRH stimulated inferior petrosal sinus sampling
Henry, J. (2018) · doi:10.5348/100005z19hr2018cr
“A central to peripheral ratio of ACTH greater than or equal to 2 before stimulation or greater than or equal to 3 after stimulation is consistent with the diagnosis of an ACTH secreting pituitary adenoma [3, 6].”
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The diagnosis of Cushing's disease
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Disorders of the adrenal gland
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Delivanis, D. A., Sharma, A. R., Hamidi, O., Shah, M., & Bancos, I. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-66195-9.00015-7 · Cited by 5
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Metadata
- Authors
- Zampetti, B., Grossrubatscher, E., Dalino Ciaramella, P., Boccardi, E., & Loli, P.
- Affiliations
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- 1Department of EndocrinologyOspedale Niguarda, Milano, Italy
- Corresponding author
- Zampetti, Benedetta
- Loli, Paola
- Venue
- Endocrine Connections
- Publisher
- Bioscientifica
- Published
- 2016-07
- Volume
- 5
- Issue
- 4
- Pages
- R12-R25
- ISSN
- 2049-3614 (ISSN-L)
- PMC
- PMC5002953
- OpenAlex
- W2474530751
- Cited by
- 130
- References
- 140
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 9 · 2023: 18 · 2022: 12 · 2021: 20 · 2020: 11 · 2019: 14 · 2018: 4 · 2017: 7 · 2016: 4
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Endocrine Connections (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- bilateral inferior petrosal sinus sampling, Cushing's syndrome, hypercortisolism, ACTH, Cushing's disease, ectopic ACTH syndrome, tumor localization, diagnostic accuracy, adverse events
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