CoChat
Sign Up
Cited by 73Hormonal and reproductive studiesLGBTQ Health, Identity, and PolicySexual Differentiation and Disorders

Safety aspects of 36 months of administration of long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals

Jacobeit, J W, Gooren, L J, Schulte, H M·2009·European Journal of Endocrinology
DOI 10.1530/eje-09-0412
Open this paper in CoChat — free account

Abstract

DESIGN: Testosterone treatment is essential for the induction and maintenance of virilization of female-to-male (FTM) transsexuals. Aim To test the safety of a novel testosterone preparation for this purpose. METHODS: Parenteral long-acting testosterone undecanoate (TU) was administered to 17 FTM transsexuals over 36 months. Observations were made while subjects received treatment. RESULTS: Serum testosterone rose from 0.50+/-0.25 to 6.2+/-1.3 ng/ml at 6 months and remained stable thereafter. The testosterone profiles were largely identical with those in hypogonadal receiving TU. There were no side effects. Over the 36 months of the study, there was a small but significant decrease in plasma cholesterol (from 218+/-47 to 188+/-42 mg/dl) and low-density lipoprotein-cholesterol (from 139+/-48 to 139+/-48 mg/dl), while plasma levels of high-density lipoprotein-cholesterol and triglycerides did not change significantly. Liver enzymes did not change during treatment. There was an increase of both levels in hemoglobin (from 13.6+/-1.2 to 16.0+/-1.5 g/dl) and hematocrit (from 41+/-4 to 46+/-4) upon administration but they remained almost without exception within the physiological range. No special measures were needed. Breast and gonads/internal genitalia did not show pathological changes over the observation period. CONCLUSION: This study reports that TU is suited for induction of virilization in FTM transsexuals without significant side effects over a longer term.

Integrity signals

Registry

Crossref · 10.1530/eje-09-0412

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Transmen receiving testosterone treatment at replacement doses to create adult male circulating testosterone concentrations exhibit increases in circulating hemoglobin to male levels.

    “Corroborative findings are available from studies of transmen (F2M transgender), that is, natal females who subsequently receive testosterone treatment at replacement doses to create adult male circulating testosterone concentrations, who exhibit increases in circulating hemoglobin to male levels [reviewed in (132–134)].”

    From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [134]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Jacobeit, J. W., Gooren, L. J., & Schulte, H. M.
Affiliations
Endokrinologikum (DE)
ORCID
Gooren, L J
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2009-11
Volume
161
Issue
5
Pages
795-798
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje-09-0412
OpenAlex
W2156966779
Cited by
73
References
27
Citations by year
2026: 2 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 8 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 1
FWCI
2.18
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
testosterone undecanoate, female-to-male transsexuals, hormone replacement therapy, masculinization, treatment safety, hypogonadism, serum cholesterol, liver enzymes, hemoglobin, adverse effects
MeSH terms
Adult, Alanine Transaminase, Aspartate Aminotransferases, Cholesterol, Female, Hematocrit, Glycated Hemoglobin, Humans, Injections, Intramuscular, Middle Aged, Testosterone, Transsexualism, Triglycerides, Statistics, Nonparametric, Testosterone Congeners, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review